Metabolic imaging of human cognition: An fMRI/1H-MRS study of brain lactate response to silent word generation

Journal of Cerebral Blood Flow and Metabolism

Volumn 23, Issue 8, 2003, Pages 942-948

  Urrila, Anna S ^a   Hakkarainen, Antti ^b   Heikkinen, Sami ^b   Vuori, Kim ^b   Stenberg, Dag ^a   Häkkinen, Anna Maija ^b   Lundbom, Nina ^b   Porkka Heiskanen, Tarja ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

1H MRS; Cognitive stimulation; fMRI; Lactate

Indexed keywords

LACTIC ACID;

ADULT; ARTICLE; AUDITORY STIMULATION; BRAIN FUNCTION; BRAIN METABOLISM; COGNITION; CONTROLLED STUDY; ENERGY RESOURCE; FEMALE; FRONTAL LOBE; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; MOTOR PERFORMANCE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TACTILE STIMULATION; TASK PERFORMANCE; VISUAL STIMULATION;

EID: 0041568573     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WCB.0000080652.64357.1D     Document Type: Article

References (29)

1. Balaban R, Bottomley P, Brown TR, Gadian D, Mountford C, Radda GK, Ross BD, Shulman RG, Springer C, Ugurbil K (1995) Advances in physiological chemistry by in vivo NMR. Magn Reson Med 34:289-292
2. Broca P (1861) Remarques sur le siège de la faculté du langage articulé; suivies d'une observation d'aphemie. Bull Soc Anat Paris 6:330-357
3. Frahm J, Kruger G, Merboldt KD, Kleinschmidt A (1996) Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man. Magn Reson Med 35:143-148
4. Friedman L, Kenny JT, Wise AL, Wu D, Stuve TA, Miller DA, Jesberger JA, Lewin JA (1998) Brain activation during silent word generation evaluated with functional MRI. Brain Lang 64:231-256
5. Hu Y, Wilson GS (1997) A temporary local energy pool coupled to neuronal activity: fluctuations of extracellular lactate levels in rat brain monitored with rapid-response enzyme-based sensor. J Neurochem 69:1484-1490
6. Kuhr WG, Korf J (1988) Extracellular lactic acid as an indicator of brain metabolism: continuous on-line measurement in conscious, freely moving rats with intrastriatal dialysis. J Cereb Blood Flow Metab 8:130-137
7. Kupfermann I (1991) Localization of higher cognitive and affective functions: the association cortices. In: Principles of neural science (Kandel ER, Schwartz JH, Jessell TM, eds), New York: Elsevier Science Publishing Co., pp 823-838
8. 1H-MRS study. Brain Res 670:326-328
9. Madsen PL, Cruz NF, Sokoloff L, Dienel GA (1999) Cerebral oxygen/glucose ratio is low during sensory stimulation and rises above normal during recovery: excess glucose consumption during stimulation is not accounted for by lactate efflux from or accumulation in brain tissue. J Cereb Blood Flow Metab 19:393-400
10. Magistretti PJ, Pellerin L (1997) Metabolic coupling during activation. A cellular view. Adv Exp Med Biol 413:161-166
11. Magistretti PJ, Pellerin L (1999) Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging. Philos Trans R Soc Lond 354:1155-1163
12. Merboldt K-D, Bruhn H, Hänicke W, Michaelis T, Frahm J (1992) Decrease of glucose in the human visual cortex during photic stimulation. Magn Reson Med 25:187-194
13. Pardo JV, Pardo PJ, Janer KW, Raichle ME (1990) The anterior cingulated cortex mediates processing selection in the Stroop attentional conflict paradigm. Proc Natl Acad Sci U S A 87:256-259
14. Phelps EA, Hyder F, Blamire AM, Shulman RG (1997) FMRI of the prefrontal cortex during overt verbal fluency. Neuroreport 8:561-565
15. Pihlajamäki M, Tanila H, Hänninen T, Könönen M, Laakso M, Partanen K, Soininen H, Aronen H (2000) Verbal fluency activates the left medial temporal lobe: a functional magnetic resonance imaging study. Ann Neurol 47:470-476
16. 1H NMR in human visual cortex during physiological stimulation. Proc Natl Acad Sci U S A 88:5829-5831
17. Pujol J, Vendrell P, Deus J, Kulisevsky J, Martí-Vilalta JL, García C, Junqué C, Capdeveila A (1996) Frontal lobe activation during word generation studied by functional MRI. Acta Neurol Scand 93:403-410
18. Richards TL, Gates GA, Gardner JC, Merrill T, Hayes CE, Panagiotides H, Serafini S, Rubel EW (1997) Functional MR spectroscopy of the auditory cortex in healthy subjects and patients with sudden hearing loss. Am J Neuroradiol 18:611-620
19. Richards TL, Dager SR, Corina D, Serafini S, Heide AC, Steury K, Strauss W, Hayes CE, Abbott RD, Craft S, Shaw D, Posse S, Beminger VW (1999) Dyslexic children have abnormal brain lactate response to reading-related language tasks. Am J Neuroradiol 20:1393-1398
20. Richards TL, Corina D, Serafini S, Steury K, Echelard DR, Dager SR, Marro K, Abbott RD, Maravilla KR, Beminger VW (2000) Effects of a phonologically driven treatment for dyslexia on lactate levels measured by proton MR spectroscopic imaging. Am J Neuroradiol 21:916-922
21. Ross B, Bluml S (2001) Magnetic resonance spectroscopy of the human brain. Anat Rec 265:54-84
22. 31p magnetic resonance spectroscopy. J Cereb Blood Flow Metab 12:584-592
23. Schlösser R, Hutchinson M, Joseffer S, Rusinek H, Saarimaki A, Stevenson J, Dewey SL, Brodie JD (1998) Functional magnetic resonance imaging of human brain activity in verbal fluency task. J Neurol Neurosurg Psychiatry 64:492-498
24. 1H MRS brain tumor time-domain data. Magn Reson Med 43:649-656
25. Shulman RG, Hyder F, Rothman DL (2001) Lactate efflux and the neuroenergetic basis of brain function. NMR Biomed 14:389-396
26. Sibson NR, Dhankar A, Mason GF, Rothman DL, Behar KL, Schulman RG (1998) Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proc Natl Acad Sci USA 95: 316-321
27. Siesjö BK (1978) Brain energy metabolism. New York: Wiley, pp 1-196
28. Ueki M, Linn F, Hossmann KA (1988) Functional activation of cerebral blood flow and metabolism before and after global ischemia of rat brain. J Cereb Blood Flow Metab 8:486-494
29. Yetkin FZ, Hammeke TA, Swanson SJ, Morris GL, Mueller WM, McAuliffe TL, Haughton, VM (1995) A comparison of functional MR activation patterns during silent and audible language tasks. Am J Neuroradiol 16:1087-1092