The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism

NeuroToxicology

Volumn 38, Issue , 2013, Pages 51-60

  Settivari, Raja ^a   VanDuyn, Natalia ^a   LeVora, Jennifer ^b   Nass, Richard ^a,b  

^a INDIANA UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Caspase; Manganism; Neurodegeneration; Neurotoxicity; Nrf2; Parkinson's disease

Indexed keywords

CASPASE; CASPASE CED 3; CASPASE CSP 1; DOPAMINE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE 1; GLUTATHIONE TRANSFERASE P1; MANGANESE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ARTICLE; CAENORHABDITIS ELEGANS; CELL DEATH; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE; GST 1 GENE; IN VIVO STUDY; NERVE CELL DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

CASPASE; DA; DOPAMINE; ECL; ENHANCED CHEMILUMINESCENCE; GFP; GREEN FLUORESCENT PROTEIN; MANGANISM; NEURODEGENERATION; NEUROTOXICITY; NRF2; PAGE; PARKINSON'S DISEASE; PD; POLYACRYLAMIDE GEL ELECTROPHORESIS; REACTIVE OXYGEN SPECIES; ROS; SN; SUBSTANTIA NIGRA; TH; TYROSINE HYDROXYLASE; WILD TYPE; WT;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CASPASES; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINERGIC NEURONS; GENE EXPRESSION; GLUTATHIONE S-TRANSFERASE PI; MANGANESE POISONING; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE DEGENERATION; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS;

EID: 84880379905     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2013.05.014     Document Type: Article

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