B cell encounters with apoptotic cells

Autoimmunity

Volumn 46, Issue 5, 2013, Pages 307-311

  Bekeredjian Ding, Isabelle ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

Apoptotic cell recognition; B cells; B regulatory cells IL 10; Toll like receptors

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; B LYMPHOCYTE DIFFERENTIATION FACTOR; B LYMPHOCYTE RECEPTOR; CELL NUCLEUS ANTIGEN; DEOXYRIBONUCLEASE; INTERLEUKIN 10; NUCLEIC ACID; TOLL LIKE RECEPTOR;

ANTIGEN BINDING; ANTIGEN RECOGNITION; APOPTOSIS; AUTOPHAGY; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CELL INTERACTION; CONCENTRATION RESPONSE; CYTOKINE RELEASE; ENDOCYTOSIS; HUMAN; IMMUNE DEFICIENCY; IMMUNOPATHOGENESIS; IMMUNOREACTIVITY; INTRACELLULAR SIGNALING; LYMPHOCYTE DIFFERENTIATION; MEMBRANE MICROPARTICLE; NONHUMAN; RECEPTOR UPREGULATION; REVIEW;

ANIMALS; APOPTOSIS; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNITY; B-LYMPHOCYTE SUBSETS; CELL COMMUNICATION; HUMANS;

EID: 84880369837     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.3109/08916934.2012.750298     Document Type: Review

References (51)

1. Ramos-Casals, M., I. Sanz, X. Bosch, J. H. Stone, and M. A. Khamashta. 2012. B-cell-depleting therapy in systemic lupus erythematosus. Am. J. Med. 125: 327-336
2. Vincent, F. B., E. F.Morand, and F. Mackay. 2012. BAFF and innate immunity: New therapeutic targets for systemic lupus erythematosus. Immunol. Cell Biol. 90: 293-303
3. Frohlich, K., J. U. Holle, P. M. Aries, W. L. Gross, and F. Moosig. 2011. Successful use of bortezomib in a patient with systemic lupus erythematosus and multiple myeloma. Ann. Rheum. Dis. 70: 1344-1345
4. Mansoor, F., A. Ali, and R. Ali. 2005. Binding of circulating SLE autoantibodies to oxygen free radical damaged chromatin. Autoimmunity 38: 431-438
5. Gaipl, U. S., L. E. Munoz, G. Grossmayer, et al. 2007. Clearance deficiency and systemic lupus erythematosus (SLE). J. Autoimmun. 28: 114-121
6. Cohen, P. L., R. Caricchio, V. Abraham, et al. 2002. Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase. J. Exp.Med. 196: 135-140
7. Cocca, B. A., A. M. Cline, and M. Z. Radic. 2002. Blebs and apoptotic bodies are B cell autoantigens. J. Immunol. 169: 159-166
8. Cocca, B. A., S. N. Seal, P. D'Agnillo, et al. 2001. Structural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cells. Proc. Natl. Acad. Sci. USA 98: 13826-13831
9. Catera, R., G. J. Silverman, K. Hatzi, et al. 2008. Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation. Mol. Med. 14: 665-674
10. Lanemo Myhrinder, A., E. Hellqvist, E. Sidorova, et al. 2008. A new perspective: Molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies. Blood 111: 3838-3848
11. Silverman, G. J., P. X. Shaw, L. Luo, et al. 2000. Neo-self antigens and the expansion of B-1 cells: Lessons from atherosclerosis-prone mice. Curr. Top. Microbiol. Immunol. 252: 189-200
12. Griffin, D. O., N. E. Holodick, and T. L. Rothstein. 2011. Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20 CD27 CD43 CD70. J. Exp. Med. 208: 67-80
13. Capolunghi, F., S. Cascioli, E. Giorda, et al. 2008. CpG drives human transitional B cells to terminal differentiation and production of natural antibodies. J. Immunol. 180: 800-808
14. Aranburu, A., S. Ceccarelli, E. Giorda, et al. 2010. TLR ligation triggers somatic hypermutation in transitional B cells inducing the generation of IgM memory B cells. J. Immunol. 185: 7293-7301
15. Feng, C. S., M. H. Ng, R. S. Szeto, and E. K. Li. 1991. Bone marrow findings in lupus patients with pancytopenia. Pathology 23: 5-7
16. Pereira, R. M., E. R. Velloso, Y. Menezes, et al. 1998. Bone marrow findings in systemic lupus erythematosus patients with peripheral cytopenias. Clin. Rheumatol. 17: 219-222
17. Baumann, I., W. Kolowos, R. E. Voll, et al. 2002. Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus. Arthritis Rheum. 46: 191-201
18. Rahman, Z. S., W. H. Shao, T. N. Khan, Y. Zhen, and P. L. Cohen. 2010. Impaired apoptotic cell clearance in the germinal center by Mer-deficient tingible body macrophages leads to enhanced antibody-forming cell and germinal center responses. J. Immunol. 185: 5859-5868
19. Hepburn, A. L., I. A. Lampert, J. J. Boyle, et al. 2007. In vivo evidence for apoptosis in the bone marrow in systemic lupus erythematosus. Ann. Rheum. Dis. 66: 1106-1109
20. Nakou, M., N. Knowlton, M. B. Frank, et al. 2008. Gene expression in systemic lupus erythematosus: Bone marrow analysis differentiates active from inactive disease and reveals apoptosis and granulopoiesis signatures. Arthritis Rheum. 58: 3541-3549
21. Xu, H., H. Li, E. Suri-Payer, R. R. Hardy, and M. Weigert. 1998. Regulation of anti-DNA B cells in recombinationactivating gene-deficient mice. J. Exp. Med. 188: 1247-1254
22. Pisetsky, D. S., and P. E. Lipsky. 2010. Microparticles as autoadjuvants in the pathogenesis of SLE. Nat. Rev. Rheumatol. 6: 368-372
23. Morbach, H., S. K. Singh, C. Faber, P. E. Lipsky, and H. J. Girschick. 2006. Analysis of RAG expression by peripheral blood CD5 and CD5- B cells of patients with childhood systemic lupus erythematosus. Ann. Rheum. Dis. 65: 482-487
24. Monestier, M., and M. Zouali. 2002. Receptor revision and systemic lupus. Scand. J. Immunol. 55: 425-431
25. Rahman, Z. S. 2011. Impaired clearance of apoptotic cells in germinal centers: Implications for loss of B cell tolerance and induction of autoimmunity. Immunol. Res. 51: 125-133
26. Hamel, K. M., V. M. Liarski, and M. R. Clark. 2012. Germinal center B-cells. Autoimmunity 45: 333-347
27. Shaw, P. X., C. S. Goodyear, M. K. Chang, J. L.Witztum, and G. J. Silverman. 2003. The autoreactivity of anti-phosphorylcholine antibodies for atherosclerosis-Associated neo-Antigens and apoptotic cells. J. Immunol. 170: 6151-6157
28. Nagata, S. 2005. DNA degradation in development and programmed cell death. Annu. Rev. Immunol. 23: 853-875
29. Pisetsky, D. S., J. Gauley, and A. J. Ullal. 2011. Microparticles as a source of extracellular DNA. Immunol. Res. 49: 227-234
30. Schiller, M., I. Bekeredjian-Ding, P. Heyder, et al. 2008. Autoantigens are translocated into small apoptotic bodies during early stages of apoptosis. Cell Death Differ. 15: 183-191
31. Bekeredjian-Ding, I., and G. Jego. 2009. Toll-like receptors- sentries in the B-cell response. Immunology 128: 311-323
32. Miao, E. A., J. V. Rajan, and A. Aderem. 2011. Caspase-1- induced pyroptotic cell death. Immunol. Rev. 243: 206-214
33. Ehlers, M.,H. Fukuyama, T. L. McGaha, A. Aderem, and J. V. Ravetch. 2006. TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J. Exp. Med. 203: 553-561
34. Capolunghi, F., M. M. Rosado, S. Cascioli, et al. 2010. Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients. Rheumatology (Oxford) 49: 2281-2289
35. Avalos, A. M., L. Busconi, and A. Marshak-Rothstein. 2010. Regulation of autoreactive B cell responses to endogenous TLR ligands. Autoimmunity 43: 76-83
36. Heyder, P., I. Bekeredjian-Ding, M. Parcina, et al. 2007. Purified apoptotic bodies stimulate plasmacytoid dendritic cells to produce IFN-Alpha. Autoimmunity 40: 331-332
37. Ronnblom, L., M. L. Eloranta, and G. V. Alm. 2003. Role of natural interferon-Alpha producing cells (plasmacytoid dendritic cells) in autoimmunity. Autoimmunity 36: 463-472
38. Jego, G., A. K. Palucka, J. P. Blanck, et al. 2003. Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity 19: 225-234
39. Poeck, H., M. Wagner, J. Battiany, et al. 2004. Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help. Blood 103: 3058-3064
40. Fransen, J. H., L. B. Hilbrands, C.W. Jacobs, et al. 2009. Both early and late apoptotic blebs are taken up by DC and induce IL-6 production. Autoimmunity 42: 325-327
41. Zandman-Goddard, G., and Y. Shoenfeld. 2005. Infections and SLE. Autoimmunity 38: 473-485
42. Lampropoulou, V., E. Calderon-Gomez, T. Roch, et al. 2010. Suppressive functions of activated B cells in autoimmune diseases reveal the dual roles of Toll-like receptors in immunity. Immunol Rev 233: 146-161
43. Chaturvedi, A., D. Dorward, and S. K. Pierce. 2008. The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigens. Immunity 28: 799-809
44. Leadbetter, E. A., I. R. Rifkin, A. M. Hohlbaum, et al. 2002. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416: 603-607
45. Hartley, S. B., M. P. Cooke, D. A. Fulcher, et al. 1993. Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death. Cell 72: 325-335
46. Isnardi, I., Y. S. Ng, I. Srdanovic, et al. 2008. IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans. Immunity 29: 746-757
47. Miles, K., J. Heaney, Z. Sibinska, et al. 2012. A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells. Proc Natl Acad Sci USA 109: 887-892
48. Iwata, Y., T. Matsushita, M. Horikawa, et al. 2011. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 117: 530-541
49. Fillatreau, S., C. H. Sweenie, M. J. McGeachy, D. Gray, and S. M. Anderton. 2002. B cells regulate autoimmunity by provision of IL-10. Nat. Immunol. 3: 944-950
50. Yanaba, K., J.D. Bouaziz, T. Matsushita, T. Tsubata, and T. F. Tedder. 2009. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J. Immunol. 182: 7459-7472
51. Busconi, L., J.W. Bauer, J. R. Tumang, et al. 2007. Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9. J. Immunol. 179: 7397-7405