The autoreactivity of anti-phosphorylcholine antibodies for atherosclerosis-associated neo-antigens and apoptotic cells

Journal of Immunology

Volumn 170, Issue 12, 2003, Pages 6151-6157

  Shaw, Peter X ^a,b   Goodyear, Carl S ^a   Chang, Mi Kyung ^a   Witztum, Joseph L ^a   Silverman, Gregg J ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; DEXAMETHASONE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; LOW DENSITY LIPOPROTEIN; MONOCLONAL ANTIBODY; NEO ANTIGEN; PHOSPHORYLCHOLINE; PHOSPHORYLCHOLINE MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN BINDING; ANTIGEN RECOGNITION; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; AUTOIMMUNE DISEASE; B LYMPHOCYTE; BACTERIAL INFECTION; CONTROLLED STUDY; CROSS REACTION; IMMUNOHISTOCHEMISTRY; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; THYMOCYTE;

EID: 0037942895     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.12.6151     Document Type: Article

References (36)

1. Silverstein, A. M. 2002. The clonal selection theory: what it really is and why modern challenges are misplaced. Nat. Immunol. 3:793.
2. Gu, H., D. Tarlinton, W. Muller, K. Rajewsky, and I. Forster. 1991. Most peripheral B cells in mice are ligand selected. J. Exp. Med. 173:1357.
3. Palinski, W., S. Hörkkö, E. Miller, U. P. Steinbrecher, H. C. Powell, L. K. Curtiss, and J. L. Witztum. 1996. Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apo E-deficient mice: demonstration of epitopes of oxidized LDL in human plasma. J. Clin. Invest. 98:800.
4. Chang, M.-K., C. Bergmark, A. Laurila, S. Hörkkö, K.-H. Han, P. Freidman, E. A. Dennis, and J. L. Witztum. 1999. Monoclonal antibodies against oxidized low density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: evidence that oxidation specific epitopes mediate macrophage recognition. Proc. Natl. Acad. Sci. USA 96:6353.
5. Hörkkö, S., E. Miller, H. Itabe, G. Subbanagounder, N. Leitinger, J. A. Berliner, P. Freidman, E. A. Dennis, L. K. Curtiss, W. Palinski, and J. L. Witztum. 1999. Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density, lipoproteins. J. Clin. Invest. 103:117.
6. Shaw, P. X., S. Hörkkö, M. K. Chang, L. K. Curtiss, W. Palinski, G. J. Silverman, and J. L. Witztum. 2000. Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity. J. Clin. Invest. 105:1731.
7. Martin, F., and J. F. Kearney. 2002. Marginal-zone B cells. Nat. Rev. Immunol. 2:323.
8. Friedman, P., S. Hörkkö, D. Steinberg, J. L. Witztum, and E. A. Dennis. 2002. Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids: importance of Schiff base formation and aldol concentration. J. Biol. Chem. 277:7010.
9. Binder, C. J., S. Hörkkö, A. Dewan, M.-K. Chang, E. Kieu, C. S. Goodyear, P. X. Shaw, W. Palinski, J. L. Witztum, and G.J. Silverman. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat. Med. In press.
10. H genes. J. Immunol. 132:1550.
11. Palinski, W., S. Ylä-Herttuala, M. E. Rosenfeld, S. W. Butler, S. A. Socher, S. Parthasarathy, L. K. Curtiss, and J. L. Witztum. 1990. Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein. Arteriosclerosis 10:325.
12. Hörkkö, S., E. Miller, D. W. Branch, W. Palinski, and J. L. Witztum. 1997. The epitopes for some antiphospholipid antibodies are adducts of oxidized phospholipid and β-2 glycoprotein 1 (and other proteins). Proc. Natl. Acad. Sci. USA 94:10356.
13. Palinski, W., R. K. Tangirala, E. Miller, S. G. Young, and J. L. Witztum. 1995. Increased autoantibody titers against epitopes of oxidized low density lipoprotein in LDL receptor-deficient mice with increased atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 15:1569.
14. H gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody. Cell 25:59.
15. Watson, A. D., N. Leitinger, M. Navab, K. F. Faull, S. Hörkkö, J. L. Witztum. W. Palinski, D. Schwenke, R. G. Salomon, W. Sha, et al. 1997. Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo. J. Biol. Chem. 272:13597.
16. Savill, J., and V. Fadok. 2000. Corpse clearance defines the meaning of cell death. Nature 407:784.
17. Stenzel-Poore, M. P., and M. B. Rittenberg. 1989. Clonal diversity, somatic mutation, and immune memory to phosphocholine-keyhole limpet hemocyanin. J. Immunol. 143:4123.
18. Taki, S., M. Meiering, and K. Rajewsky. 1993. Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus. Science 262:1268.
19. HI (T15) heavy chain. Int. Immunol. 12:873.
20. Silverman, G. J., P. X. Shaw, L. Luo, D. Dwyer, M. Chang, S. Hörkkö, W. Palinski, A. Stall, and J. L. Witztum. 2000. Neo-self antigens and the expansion of B-1 cells: lessons from atherosclerosis-prone mice. Curr. Top. Microbiol. Immunol. 252:189.
21. Vakil, M., D. E. Briles, and J. F. Kearney. 1991. Antigen-independent selection of T15 idiotype during B-cell ontogeny in mice. Dev. Immunol. 1:203.
22. Martin, F., A. M. Oliver, and J. F. Kearney. 2001. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity 14:617.
23. Cocca, B. A., S. N. Seal, P. D'Agnillo, Y. M. Mueller, P. D. Katsikis, J. Rauch, M. Weigert, and M. Z. Radic. 2001. Structural basis for autoantibody recognition of phosphatidylserine-β2 glycoprotein I and apoptotic cells. Proc. Natl. Acad. Sci. USA 98:13826.
24. Cocca, B. A., A. M. Cline. and M. Z. Radic. 2002. Blebs and apoptotic bodies are B cell autoantigens. J. Immunol. 169:159.
25. Huber, J., A. Vales, G. Mitulovic, M. Blumer, R. Schmid, J. L. Witztum, B. R. Binder, and N. Leitinger. 2002. Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactions. Arterioscler. Thromb. Vasc. Biol. 22:101.
26. 2 activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation. J. Exp. Med. 196:655.
27. C. A. Janeway, Jr. 1989. Approaching the asymptote: evolution and revolution in immunology. Cold Spring Harbor Symp. Quant. Biol. 54:1.
28. Gershov, D., S. Kim, N. Brot, and K. B. Elkon. 2000. C-reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity. J. Exp. Med. 192:1353.
29. Kushner, I. 2002. C-reactive protein and atherosclerosis. Science 297:520.
30. Chang, M. K., C. J. Binder, M. Torzewski, and J. L. Witztum. 2002. C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: phosphorylcholine of oxidized phospholipids. Proc. Natl. Acad. Sci. USA 99:13043.
31. Morahan, G., C. Berek, and J. F. Miller. 1983. An idiotypic determinant formed by both immunoglobulin constant and variable regions. Nature 301:720.
32. Wolfe, J., and J. L. Claflin. 1980. Clonal nature of the immune response to phosphocholine. IX. Heterogeneity among antibodies bearing M511 idiotypic determinants. J. Immunol. 125:2397.
33. H. Cell 19:981.
34. Claflin, J. L., J. Berry, D. Flaherty, and W. Dunnick. 1987. Somatic evolution of diversity among and-phosphocholine antibodies induced with Proteus morganii. J. Immunol. 138:3060.
35. Rudikoff, S., and M. Potter. 1976. Size differences among immunoglobulin heavy chains from phosphorylcholine-binding proteins. Proc. Natl. Acad. Sci. USA 73:2109.
36. Brown, M., M. A. Schumacher, G. D. Wiens, R. G. Brennan, and M. B. Rittenberg. 2000. The structural basis of repertoire shift in an immune response to phosphocholine. J. Exp. Med. 191:2101.