메뉴 건너뛰기




Volumn 5, Issue 12, 2010, Pages

Lysophosphatidic acid induces MDA-MB-231 breast cancer cells migration through activation of PI3K/PAK1/ ERK signaling

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; LYSOPHOSPHATIDIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; P21 ACTIVATED KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; REACTIVE OXYGEN METABOLITE; LYSOPHOSPHOLIPID; P21 ACTIVATED KINASE; PAK1 PROTEIN, HUMAN;

EID: 78651260241     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015940     Document Type: Article
Times cited : (91)

References (58)
  • 1
    • 0033604620 scopus 로고    scopus 로고
    • Bioactive lysophospholipids and their G protein-coupled receptors
    • Moolenaar WH (1999) Bioactive lysophospholipids and their G protein-coupled receptors. Exp Cell Res 253: 230-238.
    • (1999) Exp Cell Res , vol.253 , pp. 230-238
    • Moolenaar, W.H.1
  • 2
    • 0035952741 scopus 로고    scopus 로고
    • Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists
    • Kranenburg O, Moolenaar WH (2001) Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists. Oncogene 20: 1540-1546.
    • (2001) Oncogene , vol.20 , pp. 1540-1546
    • Kranenburg, O.1    Moolenaar, W.H.2
  • 3
    • 15244343497 scopus 로고    scopus 로고
    • Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer
    • Boucharaba A, Serre CM, Gres S, Saulnier-Blache JS, Bordet JC, et al. (2004) Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer. J Clin Invest 114: 1714-1725.
    • (2004) J Clin Invest , vol.114 , pp. 1714-1725
    • Boucharaba, A.1    Serre, C.M.2    Gres, S.3    Saulnier-Blache, J.S.4    Bordet, J.C.5
  • 5
    • 10744223639 scopus 로고    scopus 로고
    • Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1
    • Yamada T, Sato K, Komachi M, Malchinkhuu E, Tobo M, et al. (2004) Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1. J Biol Chem 279: 6595-6605.
    • (2004) J Biol Chem , vol.279 , pp. 6595-6605
    • Yamada, T.1    Sato, K.2    Komachi, M.3    Malchinkhuu, E.4    Tobo, M.5
  • 6
    • 77949504534 scopus 로고    scopus 로고
    • Lysophosphatidic acid production and action: Critical new players in breast cancer initiation and progression
    • Panupinthu N, Lee HY, Mills GB (2010) Lysophosphatidic acid production and action: critical new players in breast cancer initiation and progression. Br J Cancer 102: 941-946.
    • (2010) Br J Cancer , vol.102 , pp. 941-946
    • Panupinthu, N.1    Lee, H.Y.2    Mills, G.B.3
  • 7
    • 70449769732 scopus 로고    scopus 로고
    • ATX-LPA receptor axis in inflammation and cancer
    • Liu S, Murph M, Panupinthu N, Mills GB (2009) ATX-LPA receptor axis in inflammation and cancer. Cell Cycle 8: 3695-3701.
    • (2009) Cell Cycle , vol.8 , pp. 3695-3701
    • Liu, S.1    Murph, M.2    Panupinthu, N.3    Mills, G.B.4
  • 8
    • 33644843376 scopus 로고    scopus 로고
    • Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer
    • Witt AE, Hines LM, Collins NL, Hu Y, Gunawardane RN, et al. (2006) Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer. J Proteome Res 5: 599-610.
    • (2006) J Proteome Res , vol.5 , pp. 599-610
    • Witt, A.E.1    Hines, L.M.2    Collins, N.L.3    Hu, Y.4    Gunawardane, R.N.5
  • 9
    • 34247534260 scopus 로고    scopus 로고
    • Regulation and biological activities of the autotaxin-LPA axis
    • van Meeteren LA, Moolenaar WH (2007) Regulation and biological activities of the autotaxin-LPA axis. Prog Lipid Res 46: 145-160.
    • (2007) Prog Lipid Res , vol.46 , pp. 145-160
    • van Meeteren, L.A.1    Moolenaar, W.H.2
  • 10
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya T, Clevers H (2005) Wnt signalling in stem cells and cancer. Nature 434: 843-850.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 11
    • 13944259795 scopus 로고    scopus 로고
    • Targeted activation of beta-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia
    • Teuliere J, Faraldo MM, Deugnier MA, Shtutman M, Ben-Ze'ev A, et al. (2005) Targeted activation of beta-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia. Development 132: 267-277.
    • (2005) Development , vol.132 , pp. 267-277
    • Teuliere, J.1    Faraldo, M.M.2    Deugnier, M.A.3    Shtutman, M.4    Ben-Ze'ev, A.5
  • 12
    • 61749086576 scopus 로고    scopus 로고
    • Breast cancer risk in elderly women with systemic autoimmune rheumatic diseases: A population-based case-control study
    • Gadalla SM, Amr S, Langenberg P, Baumgarten M, Davidson WF, et al. (2009) Breast cancer risk in elderly women with systemic autoimmune rheumatic diseases: a population-based case-control study. Br J Cancer 100: 817-821.
    • (2009) Br J Cancer , vol.100 , pp. 817-821
    • Gadalla, S.M.1    Amr, S.2    Langenberg, P.3    Baumgarten, M.4    Davidson, W.F.5
  • 13
    • 0038554077 scopus 로고    scopus 로고
    • Biology of the p21-activated kinases
    • Bokoch GM (2003) Biology of the p21-activated kinases. Annu Rev Biochem 72: 743-781.
    • (2003) Annu Rev Biochem , vol.72 , pp. 743-781
    • Bokoch, G.M.1
  • 15
    • 2942662099 scopus 로고    scopus 로고
    • p21-activated kinase 1: An emerging therapeutic target
    • Vadlamudi RK, Kumar R (2004) p21-activated kinase 1: an emerging therapeutic target. Cancer Treat Res 119: 77-88.
    • (2004) Cancer Treat Res , vol.119 , pp. 77-88
    • Vadlamudi, R.K.1    Kumar, R.2
  • 17
    • 0034680834 scopus 로고    scopus 로고
    • Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells
    • Vadlamudi RK, Adam L, Wang RA, Mandal M, Nguyen D, et al. (2000) Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. J Biol Chem 275: 36238-36244.
    • (2000) J Biol Chem , vol.275 , pp. 36238-36244
    • Vadlamudi, R.K.1    Adam, L.2    Wang, R.A.3    Mandal, M.4    Nguyen, D.5
  • 18
    • 0034697303 scopus 로고    scopus 로고
    • Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1
    • Adam L, Vadlamudi R, Mandal M, Chernoff J, Kumar R (2000) Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1. J Biol Chem 275: 12041-12050.
    • (2000) J Biol Chem , vol.275 , pp. 12041-12050
    • Adam, L.1    Vadlamudi, R.2    Mandal, M.3    Chernoff, J.4    Kumar, R.5
  • 19
    • 0036295945 scopus 로고    scopus 로고
    • Lysophosphatidic acid stimulates p21-activated kinase in vascular smooth muscle cells
    • Schmitz U, Thommes K, Beier I, Vetter H (2002) Lysophosphatidic acid stimulates p21-activated kinase in vascular smooth muscle cells. Biochem Biophys Res Commun 291: 687-691.
    • (2002) Biochem Biophys Res Commun , vol.291 , pp. 687-691
    • Schmitz, U.1    Thommes, K.2    Beier, I.3    Vetter, H.4
  • 20
    • 2142750178 scopus 로고    scopus 로고
    • Activation of p21- activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells
    • Jung ID, Lee J, Lee KB, Park CG, Kim YK, et al. (2004) Activation of p21- activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells. Eur J Biochem 271: 1557-1565.
    • (2004) Eur J Biochem , vol.271 , pp. 1557-1565
    • Jung, I.D.1    Lee, J.2    Lee, K.B.3    Park, C.G.4    Kim, Y.K.5
  • 21
    • 31944433804 scopus 로고    scopus 로고
    • P21-activated kinase 1: Convergence point in PDGFand LPA-stimulated collagen matrix contraction by human fibroblasts
    • Rhee S, Grinnell F (2006) P21-activated kinase 1: convergence point in PDGFand LPA-stimulated collagen matrix contraction by human fibroblasts. J Cell Biol 172: 423-432.
    • (2006) J Cell Biol , vol.172 , pp. 423-432
    • Rhee, S.1    Grinnell, F.2
  • 22
    • 64549161581 scopus 로고    scopus 로고
    • Lysophosphatidic acid-induced ERK activation and chemotaxis in MC3T3-E1 preosteoblasts are independent of EGF receptor transactivation
    • Karagiosis SA, Chrisler WB, Bollinger N, Karin NJ (2009) Lysophosphatidic acid-induced ERK activation and chemotaxis in MC3T3-E1 preosteoblasts are independent of EGF receptor transactivation. J Cell Physiol 219: 716-723.
    • (2009) J Cell Physiol , vol.219 , pp. 716-723
    • Karagiosis, S.A.1    Chrisler, W.B.2    Bollinger, N.3    Karin, N.J.4
  • 23
    • 59549099037 scopus 로고    scopus 로고
    • PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics
    • Smith SD, Jaffer ZM, Chernoff J, Ridley AJ (2008) PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics. J Cell Sci 121: 3729-3736.
    • (2008) J Cell Sci , vol.121 , pp. 3729-3736
    • Smith, S.D.1    Jaffer, Z.M.2    Chernoff, J.3    Ridley, A.J.4
  • 24
    • 33750590656 scopus 로고    scopus 로고
    • Reactive oxygen species mediated sustained activation of protein kinase C alpha and extracellular signal-regulated kinase for migration of human hepatoma cell Hepg2
    • Wu WS, Tsai RK, Chang CH, Wang S, Wu JR, et al. (2006) Reactive oxygen species mediated sustained activation of protein kinase C alpha and extracellular signal-regulated kinase for migration of human hepatoma cell Hepg2. Mol Cancer Res 4: 747-758.
    • (2006) Mol Cancer Res , vol.4 , pp. 747-758
    • Wu, W.S.1    Tsai, R.K.2    Chang, C.H.3    Wang, S.4    Wu, J.R.5
  • 25
    • 33646040652 scopus 로고    scopus 로고
    • Notoginsenoside R1 inhibits TNF-alpha-induced fibronectin production in smooth muscle cells via the ROS/ERK pathway
    • Zhang HS, Wang SQ (2006) Notoginsenoside R1 inhibits TNF-alpha-induced fibronectin production in smooth muscle cells via the ROS/ERK pathway. Free Radic Biol Med 40: 1664-1674.
    • (2006) Free Radic Biol Med , vol.40 , pp. 1664-1674
    • Zhang, H.S.1    Wang, S.Q.2
  • 26
    • 34147104339 scopus 로고    scopus 로고
    • Role of receptor and nonreceptor protein tyrosine kinases in H2O2-induced PKB and ERK1/2 signaling
    • Mehdi MZ, Azar ZM, Srivastava AK (2007) Role of receptor and nonreceptor protein tyrosine kinases in H2O2-induced PKB and ERK1/2 signaling. Cell Biochem Biophys 47: 1-10.
    • (2007) Cell Biochem Biophys , vol.47 , pp. 1-10
    • Mehdi, M.Z.1    Azar, Z.M.2    Srivastava, A.K.3
  • 27
    • 34249282040 scopus 로고    scopus 로고
    • MEK1 activation by PAK: A novel mechanism
    • Park ER, Eblen ST, Catling AD (2007) MEK1 activation by PAK: a novel mechanism. Cell Signal 19: 1488-1496.
    • (2007) Cell Signal , vol.19 , pp. 1488-1496
    • Park, E.R.1    Eblen, S.T.2    Catling, A.D.3
  • 28
    • 0037040291 scopus 로고    scopus 로고
    • Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1
    • Zang M, Hayne C, Luo Z (2002) Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1. J Biol Chem 277: 4395-4405.
    • (2002) J Biol Chem , vol.277 , pp. 4395-4405
    • Zang, M.1    Hayne, C.2    Luo, Z.3
  • 29
    • 67651151233 scopus 로고    scopus 로고
    • Betaarrestin/ Ral signaling regulates lysophosphatidic acid-mediated migration and invasion of human breast tumor cells
    • Li TT, Alemayehu M, Aziziyeh AI, Pape C, Pampillo M, et al. (2009) Betaarrestin/ Ral signaling regulates lysophosphatidic acid-mediated migration and invasion of human breast tumor cells. Mol Cancer Res 7: 1064-1077.
    • (2009) Mol Cancer Res , vol.7 , pp. 1064-1077
    • Li, T.T.1    Alemayehu, M.2    Aziziyeh, A.I.3    Pape, C.4    Pampillo, M.5
  • 30
    • 17044448378 scopus 로고    scopus 로고
    • Mechanisms in LPA-induced tumor cell migration: Critical role of phosphorylated ERK
    • Stahle M, Veit C, Bachfischer U, Schierling K, Skripczynski B, et al. (2003) Mechanisms in LPA-induced tumor cell migration: critical role of phosphorylated ERK. J Cell Sci 116: 3835-3846.
    • (2003) J Cell Sci , vol.116 , pp. 3835-3846
    • Stahle, M.1    Veit, C.2    Bachfischer, U.3    Schierling, K.4    Skripczynski, B.5
  • 31
    • 0037103912 scopus 로고    scopus 로고
    • Downregulation of MMP-9 in ERK-mutated stable transfectants inhibits glioma invasion in vitro
    • Lakka SS, Jasti SL, Gondi C, Boyd D, Chandrasekar N, et al. (2002) Downregulation of MMP-9 in ERK-mutated stable transfectants inhibits glioma invasion in vitro. Oncogene 21: 5601-5608.
    • (2002) Oncogene , vol.21 , pp. 5601-5608
    • Lakka, S.S.1    Jasti, S.L.2    Gondi, C.3    Boyd, D.4    Chandrasekar, N.5
  • 33
    • 0034330547 scopus 로고    scopus 로고
    • Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells
    • Jiang K, Zhong B, Gilvary DL, Corliss BC, Hong-Geller E, et al. (2000) Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. Nat Immunol 1: 419-425.
    • (2000) Nat Immunol , vol.1 , pp. 419-425
    • Jiang, K.1    Zhong, B.2    Gilvary, D.L.3    Corliss, B.C.4    Hong-Geller, E.5
  • 34
    • 0037155159 scopus 로고    scopus 로고
    • E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts
    • Kovacs EM, Ali RG, McCormack AJ, Yap AS (2002) E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts. J Biol Chem 277: 6708-6718.
    • (2002) J Biol Chem , vol.277 , pp. 6708-6718
    • Kovacs, E.M.1    Ali, R.G.2    McCormack, A.J.3    Yap, A.S.4
  • 35
    • 0042941848 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase regulates membrane Type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell vasculogenic mimicry
    • Hess AR, Seftor EA, Seftor RE, Hendrix MJ (2003) Phosphoinositide 3-kinase regulates membrane Type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell vasculogenic mimicry. Cancer Res 63: 4757-4762.
    • (2003) Cancer Res , vol.63 , pp. 4757-4762
    • Hess, A.R.1    Seftor, E.A.2    Seftor, R.E.3    Hendrix, M.J.4
  • 36
    • 40949159866 scopus 로고    scopus 로고
    • Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype
    • Kumar B, Koul S, Khandrika L, Meacham RB, Koul HK (2008) Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype. Cancer Res 68: 1777-1785.
    • (2008) Cancer Res , vol.68 , pp. 1777-1785
    • Kumar, B.1    Koul, S.2    Khandrika, L.3    Meacham, R.B.4    Koul, H.K.5
  • 37
    • 0042887042 scopus 로고    scopus 로고
    • The emerging role of lysophosphatidic acid in cancer
    • Mills GB, Moolenaar WH (2003) The emerging role of lysophosphatidic acid in cancer. Nat Rev Cancer 3: 582-591.
    • (2003) Nat Rev Cancer , vol.3 , pp. 582-591
    • Mills, G.B.1    Moolenaar, W.H.2
  • 38
    • 34547111838 scopus 로고    scopus 로고
    • The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells
    • Lee NY, Blobe GC (2007) The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells. J Biol Chem 282: 21507-21517.
    • (2007) J Biol Chem , vol.282 , pp. 21507-21517
    • Lee, N.Y.1    Blobe, G.C.2
  • 39
    • 0036550697 scopus 로고    scopus 로고
    • Lack of ERK activation and cell migration in FGF-2-deficient endothelial cells
    • Pintucci G, Moscatelli D, Saponara F, Biernacki PR, Baumann FG, et al. (2002) Lack of ERK activation and cell migration in FGF-2-deficient endothelial cells. FASEB J 16: 598-600.
    • (2002) FASEB J , vol.16 , pp. 598-600
    • Pintucci, G.1    Moscatelli, D.2    Saponara, F.3    Biernacki, P.R.4    Baumann, F.G.5
  • 40
    • 43449090986 scopus 로고    scopus 로고
    • Lysophosphatidic acid in malignant ascites stimulates migration of human mesenchymal stem cells
    • Lee MJ, Jeon ES, Lee JS, Cho M, Suh DS, et al. (2008) Lysophosphatidic acid in malignant ascites stimulates migration of human mesenchymal stem cells. J Cell Biochem 104: 499-510.
    • (2008) J Cell Biochem , vol.104 , pp. 499-510
    • Lee, M.J.1    Jeon, E.S.2    Lee, J.S.3    Cho, M.4    Suh, D.S.5
  • 41
    • 3442876128 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma cells
    • Veit C, Genze F, Menke A, Hoeffert S, Gress TM, et al. (2004) Activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma cells. Cancer Res 64: 5291-5300.
    • (2004) Cancer Res , vol.64 , pp. 5291-5300
    • Veit, C.1    Genze, F.2    Menke, A.3    Hoeffert, S.4    Gress, T.M.5
  • 42
    • 66249138886 scopus 로고    scopus 로고
    • Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models
    • Caldas-Lopes E, Cerchietti L, Ahn JH, Clement CC, Robles AI, et al. (2009) Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proc Natl Acad Sci U S A 106: 8368-8373.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 8368-8373
    • Caldas-Lopes, E.1    Cerchietti, L.2    Ahn, J.H.3    Clement, C.C.4    Robles, A.I.5
  • 43
    • 0031036626 scopus 로고    scopus 로고
    • Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes
    • Manser E, Huang HY, Loo TH, Chen XQ, Dong JM, et al. (1997) Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes. Mol Cell Biol 17: 1129-1143.
    • (1997) Mol Cell Biol , vol.17 , pp. 1129-1143
    • Manser, E.1    Huang, H.Y.2    Loo, T.H.3    Chen, X.Q.4    Dong, J.M.5
  • 45
    • 67649773772 scopus 로고    scopus 로고
    • Trihydrophobin 1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration
    • Cheng C, Kong X, Wang H, Gan H, Hao Y, et al. (2009) Trihydrophobin 1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration. J Biol Chem 284: 8786-8796.
    • (2009) J Biol Chem , vol.284 , pp. 8786-8796
    • Cheng, C.1    Kong, X.2    Wang, H.3    Gan, H.4    Hao, Y.5
  • 46
    • 0032561206 scopus 로고    scopus 로고
    • Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase
    • Adam L, Vadlamudi R, Kondapaka SB, Chernoff J, Mendelsohn J, et al. (1998) Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase. J Biol Chem 273: 28238-28246.
    • (1998) J Biol Chem , vol.273 , pp. 28238-28246
    • Adam, L.1    Vadlamudi, R.2    Kondapaka, S.B.3    Chernoff, J.4    Mendelsohn, J.5
  • 47
    • 0036678475 scopus 로고    scopus 로고
    • Association of PI-3 kinase with PAK1 leads to actin phosphorylation and cytoskeletal reorganization
    • Papakonstanti EA, Stournaras C (2002) Association of PI-3 kinase with PAK1 leads to actin phosphorylation and cytoskeletal reorganization. Mol Biol Cell 13: 2946-2962.
    • (2002) Mol Biol Cell , vol.13 , pp. 2946-2962
    • Papakonstanti, E.A.1    Stournaras, C.2
  • 49
    • 57649096939 scopus 로고    scopus 로고
    • Akt regulates vitamin D3- induced leukemia cell functional differentiation via Raf/MEK/ERK MAPK signaling
    • Wang J, Zhao Y, Kauss MA, Spindel S, Lian H (2009) Akt regulates vitamin D3- induced leukemia cell functional differentiation via Raf/MEK/ERK MAPK signaling. Eur J Cell Biol 88: 103-115.
    • (2009) Eur J Cell Biol , vol.88 , pp. 103-115
    • Wang, J.1    Zhao, Y.2    Kauss, M.A.3    Spindel, S.4    Lian, H.5
  • 50
    • 0034816501 scopus 로고    scopus 로고
    • Raf-MEKErk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt
    • Zugasti O, Rul W, Roux P, Peyssonnaux C, Eychene A, et al. (2001) Raf-MEKErk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt. Mol Cell Biol 21: 6706-6717.
    • (2001) Mol Cell Biol , vol.21 , pp. 6706-6717
    • Zugasti, O.1    Rul, W.2    Roux, P.3    Peyssonnaux, C.4    Eychene, A.5
  • 51
    • 23944518640 scopus 로고    scopus 로고
    • Signal transduction mechanisms involved in the proliferation of C6 glioma cells induced by lysophosphatidic acid
    • Cechin SR, Dunkley PR, Rodnight R (2005) Signal transduction mechanisms involved in the proliferation of C6 glioma cells induced by lysophosphatidic acid. Neurochem Res 30: 603-611.
    • (2005) Neurochem Res , vol.30 , pp. 603-611
    • Cechin, S.R.1    Dunkley, P.R.2    Rodnight, R.3
  • 52
    • 20944445254 scopus 로고    scopus 로고
    • Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway
    • Huang Q, Shen HM, Ong CN (2005) Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway. Cell Mol Life Sci 62: 1167-1175.
    • (2005) Cell Mol Life Sci , vol.62 , pp. 1167-1175
    • Huang, Q.1    Shen, H.M.2    Ong, C.N.3
  • 53
    • 0034731505 scopus 로고    scopus 로고
    • p21- activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositidedependent kinase-1 (PDK1)
    • King CC, Gardiner EM, Zenke FT, Bohl BP, Newton AC, et al. (2000) p21- activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositidedependent kinase-1 (PDK1). J Biol Chem 275: 41201-41209.
    • (2000) J Biol Chem , vol.275 , pp. 41201-41209
    • King, C.C.1    Gardiner, E.M.2    Zenke, F.T.3    Bohl, B.P.4    Newton, A.C.5
  • 54
    • 17244367828 scopus 로고    scopus 로고
    • Reactive oxygen species in tumor progression
    • Storz P (2005) Reactive oxygen species in tumor progression. Front Biosci 10: 1881-1896.
    • (2005) Front Biosci , vol.10 , pp. 1881-1896
    • Storz, P.1
  • 55
    • 2442666453 scopus 로고    scopus 로고
    • Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factorinduced smooth muscle cell migration
    • Weber DS, Taniyama Y, Rocic P, Seshiah PN, Dechert MA, et al. (2004) Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factorinduced smooth muscle cell migration. Circ Res 94: 1219-1226.
    • (2004) Circ Res , vol.94 , pp. 1219-1226
    • Weber, D.S.1    Taniyama, Y.2    Rocic, P.3    Seshiah, P.N.4    Dechert, M.A.5
  • 56
    • 0034607872 scopus 로고    scopus 로고
    • Nerve growth factor-induced neuronal differentiation requires generation of Rac1- regulated reactive oxygen species
    • Suzukawa K, Miura K, Mitsushita J, Resau J, Hirose K, et al. (2000) Nerve growth factor-induced neuronal differentiation requires generation of Rac1- regulated reactive oxygen species. J Biol Chem 275: 13175-13178.
    • (2000) J Biol Chem , vol.275 , pp. 13175-13178
    • Suzukawa, K.1    Miura, K.2    Mitsushita, J.3    Resau, J.4    Hirose, K.5
  • 57
    • 33847618799 scopus 로고    scopus 로고
    • Albumin activation of NAD(P)H oxidase activity is mediated via Rac1 in proximal tubule cells
    • Whaley-Connell AT, Morris EM, Rehmer N, Yaghoubian JC, Wei Y, et al. (2007) Albumin activation of NAD(P)H oxidase activity is mediated via Rac1 in proximal tubule cells. Am J Nephrol 27: 15-23.
    • (2007) Am J Nephrol , vol.27 , pp. 15-23
    • Whaley-Connell, A.T.1    Morris, E.M.2    Rehmer, N.3    Yaghoubian, J.C.4    Wei, Y.5
  • 58
    • 0036140989 scopus 로고    scopus 로고
    • Effects of receptor tyrosine kinase inhibitor A47 on estrogen and growth factor-dependent breast cancer cell proliferation and apoptosis in vitro
    • Turbov JM, Twaddle GM, Yang X, Liu NM, Murthy S (2002) Effects of receptor tyrosine kinase inhibitor A47 on estrogen and growth factor-dependent breast cancer cell proliferation and apoptosis in vitro. J Surg Oncol 79: 17-29.
    • (2002) J Surg Oncol , vol.79 , pp. 17-29
    • Turbov, J.M.1    Twaddle, G.M.2    Yang, X.3    Liu, N.M.4    Murthy, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.