A transgenic zebrafish model of a human cardiac sodium channel mutation exhibits bradycardia, conduction-system abnormalities and early death

Journal of Molecular and Cellular Cardiology

Volumn 61, Issue , 2013, Pages 123-132

  Huttner, Inken G ^a   Trivedi, Gunjan ^a   Jacoby, Arie ^a   Mann, Stefan A ^a   Vandenberg, Jamie I ^a,c   Fatkin, Diane ^a,b,c  

^a VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Cardiac arrhythmia; Cardiac sodium channel; Gene mutation; Transgenesis; Zebrafish

Indexed keywords

SODIUM CHANNEL; SODIUM CHANNEL NAV1.5;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MODEL; EMBRYO; GENE; GENE EXPRESSION; GENE MUTATION; GENETIC CONSERVATION; GENETIC VARIABILITY; HEART MUSCLE CONDUCTION DISTURBANCE; MORTALITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCN5A GENE; TELEOST; TRANSGENIC ANIMAL; WILD TYPE; ZEBRA FISH;

Α-CRY; ACTION POTENTIAL; ALPHA-CRYSTALLIN; AP; ATRIO-VENTRICULAR; AV; BEATS PER MINUTE; BPM; CARDIAC ARRHYTHMIA; CARDIAC CONDUCTION DISEASE; CARDIAC MYOSIN LIGHT CHAIN 2; CARDIAC SODIUM CHANNEL; CCD; CMLC2; DAYS POST FERTILIZATION; DCM; DILATED CARDIOMYOPATHY; DPF; ECG; ELECTROCARDIOGRAM; FRACTIONAL SHORTENING; FS; GENE MUTATION; NA(+) CHANNEL; PCR; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE; RT; TRANSGENESIS; WILD-TYPE; WT; ZEBRAFISH;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BRADYCARDIA; DISEASE MODELS, ANIMAL; HEART CONDUCTION SYSTEM; HEART RATE; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; PENETRANCE; PHENOTYPE; ZEBRAFISH;

DANIO RERIO; MURINAE; MUS; TELEOSTEI;

EID: 84880329405     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2013.06.005     Document Type: Article

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