Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy

Nature Medicine

Volumn 15, Issue 11, 2009, Pages 1281-1288

  Hassel, David ^a   Dahme, Tillman ^a   Erdmann, Jeanette ^b   Meder, Benjamin ^a   Huge, Andreas ^c   Stoll, Monika ^c   Just, Steffen ^a   Hess, Alexander ^a   Ehlermann, Philipp ^a   Weichenhan, Dieter ^a   Grimmler, Matthias ^d   Liptau, Henrike ^b   Hetzer, Roland ^e   Regitz Zagrosek, Vera ^e,f   Fischer, Christine ^a   Nürnberg, Peter ^g   Schunkert, Heribert ^b   Katus, Hugo A ^a   Rottbauer, Wolfgang ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d UNIVERSITY OF WÜRZBURG   (Germany)

^e DEUTSCHES HERZZENTRUM BERLIN   (Germany)

^f DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^g UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID BINDING PROTEIN; NEXILIN PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ALLELE; ANIMAL CELL; ARTICLE; CONGESTIVE CARDIOMYOPATHY; EMBRYO; FEMALE; GENE DELETION; GENE ISOLATION; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC CODE; HEART FAILURE; HEART MUSCLE CELL; HEART STRESS; HETEROZYGOTE; HUMAN; HUMAN TISSUE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN ISOLATION; SKELETAL MUSCLE; Z DISK MUSCLE; ZEBRA FISH;

DANIO RERIO;

ADULT; AGED; AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CARDIOMYOPATHY, DILATED; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 1; COMPUTATIONAL BIOLOGY; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; FAMILY HEALTH; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MICROFILAMENT PROTEINS; MIDDLE AGED; MUSCLE CONTRACTION; MUSCLE FIBERS, SKELETAL; MUTATION; MYOCARDIUM; MYOCYTES, CARDIAC; POLYMORPHISM, SINGLE NUCLEOTIDE; SARCOMERES; ZEBRAFISH;

EID: 70449119936     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2037     Document Type: Article

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