High-sugar diets, type 2 diabetes and Alzheimer's disease

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 16, Issue 4, 2013, Pages 440-445

  Moreira, Paula I ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Alzheimer's disease; High sugar diets; Insulin resistance; Type 2 diabetes

Indexed keywords

AMINOMETHYLTRANSFERASE; FRUCTOSE; GLUCOSE; INSULIN; SUCROSE;

ALZHEIMER DISEASE; CARDIOVASCULAR RISK; COGNITIVE DEFECT; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN RESISTANCE; LIFESTYLE; MORBIDITY; NEUROPATHOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHOSPHORYLATION; REVIEW; SUGAR INTAKE;

ALZHEIMER DISEASE; ANIMALS; COGNITION DISORDERS; DIABETES MELLITUS, TYPE 2; DIET; DIETARY SUCROSE; DISEASE MODELS, ANIMAL; HUMANS; INSULIN RESISTANCE; OBESITY; RISK FACTORS; WEIGHT GAIN;

EID: 84880326722     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0b013e328361c7d1     Document Type: Review

References (35)

1. Correia SC, Santos RX, Carvalho C, et al. Insulin signaling, glucose metabolism and mitochondria:major players in Alzheimer's disease and diabetes interrelation. Brain Res 2012; 1441:64-78.
2. Moreira PI. Alzheimer's disease and diabetes:an integrative view of the role of mitochondria, oxidative stress, and insulin. J Alzheimers Dis 2012; 30:S199-S215.
3. Correia SC, Santos RX, Cardoso S, et al. Alzheimer disease as a vascular disorder:where do mitochondria fit? Exp Gerontol 2012; 47:878-886.
4. Atkinson FS, Foster-Powell K, Brand-Miller JC. International tables of glycemic index and glycemic load values. Diabetes Care 2008; 31:2281-2283.
5. Chong MF, Fielding BA, Frayn KN. Mechanisms for the acute effect of fructose on postprandial lipemia. Am J Clin Nutr 2007; 85:1511-1520.
6. Couchepin C, Le KA, Bortolotti M, et al. Markedly blunted metabolic effects of fructose in healthy young female subjects compared with male subjects. Diabetes Care 2008; 31:1254-1256.
7. Stanhope KL, Griffen SC, Bair BR, et al. Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals. Am J Clin Nutr 2008; 87:1194-1203.
8. Le KA, Ith M, Kreis R, et al. Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes. Am J Clin Nutr 2009; 89:1760-1765.
9. Stanhope KL, Schwarz JM, Keim NL, et al. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 2009; 119:1322-1334.
10. Aeberli I, Hochuli M, Gerber PA, et al. Moderate amounts of fructose consumption impair insulin sensitivity in healthy young men:A randomized controlled trial. Diabetes Care 2013; 36:150-156.
11. Cha SH, Wolfgang M, Tokutake Y, et al. Differential effects of central fructose and glucose on hypothalamic malonyl-CoA and food intake. Proc Natl Acad Sci U S A 2008; 105:16871-16875.
12. Page KA, Chan O, Arora J, et al. Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways. JAMA 2013; 309:63-70.
13. Purnell JQ, Klopfenstein BA, Stevens AA, et al. Brain functional magnetic resonance imaging response to glucose and fructose infusions in humans. Diabetes Obes Metab 2011; 13:229-234.
14. Bizeau ME, Pagliassotti MJ. Hepatic adaptations to sucrose and fructose. Metab Clin Exp 2005; 54:1189-1201.
15. Higgins PB, Bastarrachea RA, Lopez-Alvarenga JC, et al. Eight week exposure to a high sugar high fat diet results in adiposity gain and alterations in metabolic biomarkers in baboons (Papio hamadryas sp.). Cardiovasc Diabetol 2010; 9:71-77.
16. Carvalho C, Cardoso S, Correia SC, et al. Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities. Diabetes 2012; 61:1234-1242.
17. Goldbart AD, Row BW, Kheirandish-Gozal L, et al. High fat/refined carbohydrate diet enhances the susceptibility to spatial learning deficits in rats exposed to intermittent hypoxia. Brain Res 2006; 1090:190-196.
18. Jurdak N, Lichtenstein AH, Kanarek RB. Diet-induced obesity and spatial cognition in young male rats. Nutr Neurosci 2008; 11:48-54.
19. Stranahan AM, Norman ED, Lee K, et al. Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus 2008; 18:1085-1088.
20. Mielke JG, Taghibiglou C, Liu L, et al. A biochemical and functional characterization of diet-induced brain insulin resistance. J Neurochem 2005; 93:1568-1578.
21. Cao D, Lu H, Lewis TL, Li L. Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease. J Biol Chem 2007; 282:36275-36282.
22. Carvalho C, Machado N, Mota P, et al. Type 2 diabetic and Alzheimer's disease mice present similar behavioral, cognitive and vascular anomalies. J Alzheimers Dis (in press).
23. Ho L, Qin W, Pompl PN, et al. Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. FASEB J 2004; 18:902-904.
24. Pedersen WA, McMillan PJ, Kulstad JJ, et al. Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice. Exp Neurol 2006; 199:265-273.
25. Schubert M, Brazil DP, Burks DJ, et al. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 2003; 23:7084-7092.
26. Schubert M, Gautam D, Surjo D, et al. Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A 2004; 101:3100-3105.
27. Freude S, Plum L, Schnitker J, et al. Peripheral hyperinsulinemia promotes tau phosphorylation in vivo. Diabetes 2005; 54:3343-3348.
28. Noble W, Planel E, Zehr C, et al. Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proc Natl Acad Sci U S A 2005; 102:6990-6995.
29. Kroner Z. The relationship between Alzheimer's disease and diabetes:type 3 diabetes? Altern Med Rev 2009; 14:373-379.
30. Pasquier F, Boulogne A, Leys D, Fontaine P. Diabetes mellitus and dementia. Diabetes Metab 2006; 32:403-414.
31. Manschot SM, Biessels GJ, de Valk H, et al. Metabolic and vascular determinants of impaired cognitive performance and abnormalities on brain magnetic resonance imaging in patients with type 2 diabetes. Diabetologia 2007; 50:2388-2397.
32. Manschot SM, Brands AM, van der Grond J, et al. Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes. Diabetes 2006; 55:1106-1113.
33. Tiehuis AM, van der Graaf Y, Visseren FL, et al. Diabetes increases atrophy and vascular lesions on brain MRI in patients with symptomatic arterial disease. Stroke 2008; 39:1600-1603.
34. Sun A, Liu M, Nguyen XV, Bing G. P38 MAP kinase is activated at early stages in Alzheimer's disease brain. Exp Neurol 2003; 183:394-405.
35. Pei JJ, Khatoon S, An WL, et al. Role of protein kinase B in Alzheimer's neurofibrillary pathology. Acta Neuropathol 2003; 105:381-392.