Metabolomics in pneumonia and sepsis: An analysis of the GenIMS cohort study

Intensive Care Medicine

Volumn 39, Issue 8, 2013, Pages 1423-1434

  Seymour, Christopher W ^a   Yende, Sachin ^a   Scott, Melanie J ^a   Pribis, John ^a   Mohney, Robert P ^b   Bell, Lauren N ^b   Chen, Yi Fan ^c   Zuckerbraun, Brian S ^a   Bigbee, William L ^d   Yealy, Donald M ^a   Weissfeld, Lisa ^c   Kellum, John A ^a   Angus, Derek C ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b METABOLON INC   (United States)

^c UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Biomarker; Metabolomics; Pneumonia; Sepsis

Indexed keywords

BILE ACID; INTERLEUKIN 1BETA; PROCALCITONIN; PSEUDOURIDINE; TUMOR NECROSIS FACTOR ALPHA;

AGED; ARTICLE; BILE ACID METABOLISM; BLOOD SAMPLING; CLINICAL ARTICLE; COMMUNITY ACQUIRED PNEUMONIA; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; HUMAN; IN VITRO STUDY; KIDNEY HOMOGENATE; LIVER; MALE; METABOLOMICS; MONOCYTE; OXIDATIVE STRESS; PLASMA; PROGNOSIS; PROSPECTIVE STUDY; SEPSIS; STRESS; SURVIVOR;

AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; COHORT STUDIES; COMMUNITY-ACQUIRED INFECTIONS; FEMALE; HUMANS; MALE; METABOLOMICS; PNEUMONIA; PROSPECTIVE STUDIES; SEPSIS;

EID: 84880289108     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-013-2935-7     Document Type: Article

References (41)

1. Poeze M, Ramsay G, Gerlach H, Rubulotta F, Levy M (2004) An international sepsis survey: a study of doctors' knowledge and perception about sepsis. Crit Care 8:R409-R413
2. Ferrer R, Artigas A, Levy MM, Blanco J, Gonzalez-Diaz G, Garnacho-Montero J, Ibanez J, Palencia E, Quintana M, de la Torre-Prados MV (2008) Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. JAMA 299:2294-2303
3. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR (2001) Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29:1303-1310
4. Pierrakos C, Vincent JL (2010) Sepsis biomarkers: a review. Crit Care 14:R15
5. Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ, Chen RO, Brownstein BH, Cobb JP, Tschoeke SK, Miller-Graziano C, Moldawer LL, Mindrinos MN, Davis RW, Tompkins RG, Lowry SF (2005) A network-based analysis of systemic inflammation in humans. Nature 437:1032-1037
6. Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA (2010) Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA 303:739-746
7. Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S, Gardlund B, Marshall JC, Rhodes A, Artigas A, Payen D, Tenhunen J, Al-Khalidi HR, Thompson V, Janes J, Macias WL, Vangerow B, Williams MD (2012) Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med 366:2055-2064
8. Wong HR, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Lin R, Shanley TP, Bigham MT, Wheeler DS, Doughty LA, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Varisco BM, Barr FE (2011) Validation of a gene expression-based subclassification strategy for pediatric septic shock. Crit Care Med 39:2511-2517
9. Serkova NJ, Standiford TJ, Stringer KA (2011) The emerging field of quantitative blood metabolomics for biomarker discovery in critical illnesses. Am J Resp Crit Care Med 184(6):647-655
10. Izquierdo-Garcia JL, Nin N, Ruiz-Cabello J, Rojas Y, de Paula M, Lopez-Cuenca S, Morales L, Martinez-Caro L, Fernandez-Segoviano P, Esteban A, Lorente JA (2011) A metabolomic approach for diagnosis of experimental sepsis. Intensive Care Med [Epub ahead of print]
11. Liu XR, Zheng XF, Ji SZ, Lv YH, Zheng DY, Xia ZF, Zhang WD (2010) Metabolomic analysis of thermally injured and/or septic rats. Burns 36:992-998
12. Hinkelbein J, Feldmann RE Jr, Peterka A, Schubert C, Schelshorn D, Maurer MH, Kalenka A (2007) Alterations in cerebral metabolomics and proteomic expression during sepsis. Curr Neurovasc Res 4:280-288
13. Xu PB, Lin ZY, Meng HB, Yan SK, Yang Y, Liu XR, Li JB, Deng XM, Zhang WD (2008) A metabonomic approach to early prognostic evaluation of experimental sepsis. J Infect 56:474-481
14. Adams Wilson JR, Morandi A, Girard TD, Thompson JL, Boomershine CS, Shintani AK, Ely EW, Pandharipande PP (2012) The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness. Crit Care Med 40:835-841
15. Bruegel M, Ludwig U, Kleinhempel A, Petros S, Kortz L, Ceglarek U, Holdt LM, Thiery J, Fiedler GM (2012) Sepsis-associated changes of the arachidonic acid metabolism and their diagnostic potential in septic patients. Crit Care Med 40:1478-1486
16. Gough MS, Morgan MA, Mack CM, Darling DC, Frasier LM, Doolin KP, Apostolakos MJ, Stewart JC, Graves BT, Arning E, Bottiglieri T, Mooney RA, Frampton MW, Pietropaoli AP (2011) The ratio of arginine to dimethylarginines is reduced and predicts outcomes in patients with severe sepsis. Crit Care Med 39:1351-1358
17. Semmler A, Smulders Y, Struys E, Smith D, Moskau S, Blom H, Linnebank M (2008) Methionine metabolism in an animal model of sepsis. Clin Chem Lab Med 46:1398-1402
18. 1H-nuclear magnetic resonance quantitative metabolomics and computational analysis. Am J Physiol Lung Cell Mol Physiol 300:L4-L11
19. Breslow NE, Holubkov R (1997) Maximum likelihood estimation of logistic regression parameters under two phase, outcome-dependent sampling. J R Stat Soc Ser C Appl Stat 59:447-461
20. Selberg O, Hecker H, Martin M, Klos A, Bautsch W, Kohl J (2000) Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin-6. Crit Care Med 28:2793-2798
21. Lawton KA, Berger A, Mitchell M, Milgram KE, Evans AM, Guo L, Hanson RW, Kalhan SC, Ryals JA, Milburn MV (2008) Analysis of the adult human plasma metabolome. Pharmacogenomics 9:383-397
22. Dehaven CD, Evans AM, Dai H, Lawton KA (2010) Organization of GC/MS and LC/MS metabolomics data into chemical libraries. J Cheminform 2:9
23. Bleiblo F, Michael P, Brabant D, Ramana CV, Tai T, Saleh M, Parrillo JE, Kumar A (2012) The role of immunostimulatory nucleic acids in septic shock. Int J Clin Exp Med 5:1-23
24. Storey JD, Tibshirani R (2003) Statistical significance for genomewide studies. Proc Nat Acad Sci USA 100:9440-9445
25. Green RM, Beier D, Gollan JL (1996) Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology 111:193-198
26. Trauner M, Arrese M, Lee H, Boyer JL, Karpen SJ (1998) Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. J Clin Inv 101:2092-2100
27. Han X, Fink MP, Uchiyama T, Yang R, Delude RL (2004) Increased iNOS activity is essential for hepatic epithelial tight junction dysfunction in endotoxemic mice. Am J Physiol Gastrointest Liver Physiol 286:G126-G136
28. Chernow B, Alexander HR, Smallridge RC, Thompson WR, Cook D, Beardsley D, Fink MP, Lake CR, Fletcher JR (1987) Hormonal responses to graded surgical stress. Arch Int Med 147:1273-1278
29. Hasselgren PO, Pedersen P, Sax HC, Warner BW, Fischer JE (1988) Current concepts of protein turnover and amino acid transport in liver and skeletal muscle during sepsis. Arch Surg 123:992-999
30. Lagendijk J, Ubbink JB, Vermaak WJ (1995) The determination of allantoin, a possible indicator of oxidant status, in human plasma. J Chromatogr Sci 33:186-193
31. Ramazzina I, Folli C, Secchi A, Berni R, Percudani R (2006) Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes. Nat Chem Biol 2:144-148
32. Shi Y, Zheng W, Rock KL (2000) Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses. Proc Nat Acad Sci USA 97:14590-14595
33. Ishii KJ, Suzuki K, Coban C, Takeshita F, Itoh Y, Matoba H, Kohn LD, Klinman DM (2001) Genomic DNA released by dying cells induces the maturation of APCs. J Immunol 167:2602-2607
34. Shi Y, Evans JE, Rock KL (2003) Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425:516-521
35. Tavazzi B, Batocchi AP, Amorini AM, Nociti V, D'Urso S, Longo S, Gullotta S, Picardi M, Lazzarino G (2011) Serum metabolic profile in multiple sclerosis patients. Mult Scler Int 2011:167156
36. Amuro Y, Nakaoka H, Shimomura S, Fujikura M, Yamamoto T, Tamura S, Hada T, Higashino K (1988) Serum pseudouridine as a biochemical marker in patients with hepatocellular carcinoma. Clin Chim Acta 178:151-158
37. Angus DC, Yang L, Kong L, Kellum JA, Delude RL, Tracey KJ, Weissfeld L (2007) Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis. Crit Care Med 35:1061-1067
38. Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D, Wagele B, Altmaier E, Deloukas P, Erdmann J, Grundberg E, Hammond CJ, de Angelis MH, Kastenmuller G, Kottgen A, Kronenberg F, Mangino M, Meisinger C, Meitinger T, Mewes HW, Milburn MV, Prehn C, Raffler J, Ried JS, Romisch-Margl W, Samani NJ, Small KS, Wichmann HE, Zhai G, Illig T, Spector TD, Adamski J, Soranzo N, Gieger C (2011) Human metabolic individuality in biomedical and pharmaceutical research. Nature 477:54-60
39. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM (2009) Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 457:910-914
40. Pan Z, Raftery D (2007) Comparing and combining NMR spectroscopy and mass spectrometry in metabolomics. Anal Bioanal Chem 387:525-527
41. Beier K, Eppanapally S, Bazick HS, Chang D, Mahadevappa K, Gibbons FK, Christopher KB (2011) Elevation of blood urea nitrogen is predictive of long-term mortality in critically ill patients independent of "normal" creatinine. Crit Care Med 39:305-313