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Volumn 39, Issue 6, 2011, Pages 1351-1358

The ratio of arginine to dimethylarginines is reduced and predicts outcomes in patients with severe sepsis

Author keywords

amino acids; arginine; critical care; nitric oxide; sepsis; septic shock

Indexed keywords

ARGININE; ARGININE DERIVATIVE; BIOLOGICAL MARKER; CREATININE; DIMETHYLARGININE; NITRATE; UNCLASSIFIED DRUG;

EID: 85027945709     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318212097c     Document Type: Article
Times cited : (40)

References (48)
  • 1
    • 44049093984 scopus 로고    scopus 로고
    • Resuscitating the microcirculation in sepsis: The central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials
    • Trzeciak S, Cinel I, Phillip Dellinger R, et al: Resuscitating the microcirculation in sepsis: The central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med 2008; 15:399-413.
    • (2008) Acad Emerg Med , vol.15 , pp. 399-413
    • Trzeciak, S.1    Cinel, I.2    Phillip Dellinger, R.3
  • 2
    • 2942577486 scopus 로고    scopus 로고
    • Cardiovascular biology of the asymmetric dimethylarginine: dimethylarginine dimethylaminohydrolase pathway
    • DOI 10.1161/01.ATV.0000128897.54893.26
    • Vallance P, Leiper J: Cardiovascular biology of the asymmetric dimethylarginine:Dimethylarginine dimethylaminohydrolase pathway. Arterioscler Thromb Vasc Biol 2004; 24:1023-1030. (Pubitemid 38737826)
    • (2004) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.24 , Issue.6 , pp. 1023-1030
    • Vallance, P.1    Leiper, J.2
  • 3
    • 33645473328 scopus 로고    scopus 로고
    • Symmetrical dimethylarginine: A new combined parameter for renal function and extent of coronary artery disease
    • Bode-Böger SM, Scalera F, Kielstein JT, et al: Symmetrical dimethylarginine: A new combined parameter for renal function and extent of coronary artery disease. J Am Soc Nephrol 2006; 17:1128-1134.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1128-1134
    • Bode-Böger, S.M.1    Scalera, F.2    Kielstein, J.T.3
  • 5
    • 52749084926 scopus 로고    scopus 로고
    • Alterations of the arginine metabolome in asthma
    • Lara A, Khatri SB, Wang Z, et al: Alterations of the arginine metabolome in asthma. Am J Respir Crit Care Med 2008; 178:673-681.
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 673-681
    • Lara, A.1    Khatri, S.B.2    Wang, Z.3
  • 7
    • 0018677546 scopus 로고
    • Plasma amino acids as predictors of the severity and outcome of sepsis
    • Freund H, Atamian S, Holroyde J, et al: Plasma amino acids as predictors of the severity and outcome of sepsis. Ann Surg 1979; 190:571-576. (Pubitemid 10213662)
    • (1979) Annals of Surgery , vol.190 , Issue.5 , pp. 571-576
    • Freund, H.1    Atamian, S.2    Holroyde, J.3    Fischer, J.E.4
  • 9
    • 58149379390 scopus 로고    scopus 로고
    • Reduced citrulline production in sepsis is related to diminished de novo arginine and nitric oxide production
    • Luiking YC, Poeze M, Ramsay G, et al: Reduced citrulline production in sepsis is related to diminished de novo arginine and nitric oxide production. Am J Clin Nutr 2009; 89:142-152.
    • (2009) Am J Clin Nutr , vol.89 , pp. 142-152
    • Luiking, Y.C.1    Poeze, M.2    Ramsay, G.3
  • 11
    • 12244262222 scopus 로고    scopus 로고
    • Asymmetrical dimethylarginine (adma) in critically ill patients: High plasma ADMA concentration is an independent risk factor of icu mortality
    • Nijveldt RJ, Teerlink T, van der Hoven B, et al: Asymmetrical dimethylarginine (adma) in critically ill patients: High plasma ADMA concentration is an independent risk factor of icu mortality. Clin Nutr 2003; 22:22-30.
    • (2003) Clin Nutr , vol.22 , pp. 22-30
    • Nijveldt, R.J.1    Teerlink, T.2    Van Der Hoven, B.3
  • 12
    • 14944373609 scopus 로고    scopus 로고
    • Modulation of asymmetric dimethylarginine in critically ill patients receiving intensive insulin treatment: A possible explanation of reduced morbidity and mortality?
    • DOI 10.1097/01.CCM.0000155784.59297.50
    • Siroen MP, van Leeuwen PA, Nijveldt RJ, et al: Modulation of asymmetric dimethylarginine in critically ill patients receiving intensive insulin treatment: A possible explanation of reduced morbidity and mortality? Crit Care Med 2005; 33:504-510. (Pubitemid 40365549)
    • (2005) Critical Care Medicine , vol.33 , Issue.3 , pp. 504-510
    • Siroen, M.P.C.1    Van Leeuwen, P.A.M.2    Nijveldt, R.J.3    Teerlink, T.4    Wouters, P.J.5    Van Den Berghe, G.6
  • 13
    • 34447628068 scopus 로고    scopus 로고
    • Septic shock is correlated with asymmetrical dimethylarginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: A prospective observational study
    • O'Dwyer M, Dempsey F, Crowley V, et al: Septic shock is correlated with asymmetrical dimethylarginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: A prospective observational study. Crit Care 2006; 10:R139.
    • (2006) Crit Care , vol.10
    • O'Dwyer, M.1    Dempsey, F.2    Crowley, V.3
  • 14
    • 2942752473 scopus 로고    scopus 로고
    • Acute Escherichia coli endotoxaemia decreases the plasma L-arginine/asymmetrical dimethylarginine ratio in humans
    • DOI 10.1042/CS20030363
    • Mittermayer F, Namiranian K, Pleiner J, et al: Acute Escherichia coli endotoxaemia decreases the plasma L-arginine/asymmetrical dimethylargine ratio in humans. Clin Sci 2004; 106:577-581. (Pubitemid 38797569)
    • (2004) Clinical Science , vol.106 , Issue.6 , pp. 577-581
    • Mittermayer, F.1    Namiranian, K.2    Pleiner, J.3    Schaller, G.4    Wolzt, M.5
  • 15
    • 66449112861 scopus 로고    scopus 로고
    • Low arginine/asymmetric dimethylarginine ratio deteriorates systemic hemodynamics and organ blood flow in a rat model
    • Richir MC, van Lambalgen AA, Teerlink T, et al: Low arginine/asymmetric dimethylarginine ratio deteriorates systemic hemodynamics and organ blood flow in a rat model. Crit Care Med 2009; 37:2010-2017.
    • (2009) Crit Care Med , vol.37 , pp. 2010-2017
    • Richir, M.C.1    Van Lambalgen, A.A.2    Teerlink, T.3
  • 17
    • 77950221960 scopus 로고    scopus 로고
    • Artery-to-vein differences in nitric oxide metabolites are diminished in sepsis
    • Morgan MA, Frasier LM, Stewart JC, et al: Artery-to-vein differences in nitric oxide metabolites are diminished in sepsis. Crit Care Med 2010; 38:1069-1077.
    • (2010) Crit Care Med , vol.38 , pp. 1069-1077
    • Morgan, M.A.1    Frasier, L.M.2    Stewart, J.C.3
  • 18
    • 0026710191 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
    • The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine
    • Bone RC, Balk RA, Cerra FB, et al: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101:1644-1655.
    • (1992) Chest , vol.101 , pp. 1644-1655
    • Bone, R.C.1    Balk, R.A.2    Cerra, F.B.3
  • 22
    • 0030015661 scopus 로고    scopus 로고
    • The SOFA (Sepsis-Related Organ Failure Assessment) score to describe organ dysfunction/ failure on behalf of the working group on sepsis-related problems of the european society of intensive care medicine
    • Vincent JL, Moreno R, Takala J, et al: The SOFA (Sepsis-Related Organ Failure Assessment) score to describe organ dysfunction/ failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996; 22:707-710.
    • (1996) Intensive Care Med , vol.22 , pp. 707-710
    • Vincent, J.L.1    Moreno, R.2    Takala, J.3
  • 24
    • 0023092594 scopus 로고
    • A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation
    • DOI 10.1016/0021-9681(87)90171-8
    • Charlson ME, Pompei P, Ales KL, et al: A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis 1987; 40:373-383. (Pubitemid 17055592)
    • (1987) Journal of Chronic Diseases , vol.40 , Issue.5 , pp. 373-383
    • Charlson, M.E.1    Pompei, P.2    Ales, K.A.3    MacKenzie, C.R.4
  • 25
    • 33644559016 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA) as a risk marker for stroke and TIA in a Swedish population
    • Wanby P, Teerlink T, Brudin L, et al: Asymmetric dimethylarginine (ADMA) as a risk marker for stroke and TIA in a Swedish population. Atherosclerosis 2006; 185:271-277.
    • (2006) Atherosclerosis , vol.185 , pp. 271-277
    • Wanby, P.1    Teerlink, T.2    Brudin, L.3
  • 26
    • 20044374001 scopus 로고    scopus 로고
    • Plasma asymmetric dimethylarginine concentrations in newly diagnosed patients with acute myocardial infarction or unstable angina pectoris during two weeks of medical treatment
    • Bae SW, Stü hlinger MC, Yoo HS, et al: Plasma asymmetric dimethylarginine concentrations in newly diagnosed patients with acute myocardial infarction or unstable angina pectoris during two weeks of medical treatment. Am J Cardiol 2005; 95:729-733.
    • (2005) Am J Cardiol , vol.95 , pp. 729-733
    • Bae Sw, S.1
  • 28
    • 0033594888 scopus 로고    scopus 로고
    • Novel mechanism for endothelial dysfunction: Dysregulation of dimethylarginine dimethylaminohydrolase
    • Ito A, Tsao PS, Adimoolam S, et al: Novel mechanism for endothelial dysfunction: Dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 1999; 99: 3092-3095. (Pubitemid 29289071)
    • (1999) Circulation , vol.99 , Issue.24 , pp. 3092-3095
    • Ito, A.1    Tsao, P.S.2    Adimoolam, S.3    Kimoto, M.4    Ogawa, T.5    Cooke, J.P.6
  • 29
    • 34548175761 scopus 로고    scopus 로고
    • Use of exogenous arginine in multiple organ dysfunction syndrome and sepsis
    • DOI 10.1097/01.CCM.0000279188.97421.FE, PII 0000324620070900100022
    • Barbul A, Uliyargoli A: Use of exogenous arginine in multiple organ dysfunction syndrome and sepsis. Crit Care Med 2007; 35: S564-S567. (Pubitemid 47312196)
    • (2007) Critical Care Medicine , vol.35 , Issue.9 SUPPL.
    • Barbul, A.1    Uliyargoli, A.2
  • 30
    • 0029900905 scopus 로고    scopus 로고
    • Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury
    • Xia Y, Dawson VL, Dawson TM, et al: Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury. Proc Nat Acad Sci USA 1996; 93:6770-6774.
    • (1996) Proc Nat Acad Sci USA , vol.93 , pp. 6770-6774
    • Xia, Y.1    Dawson, V.L.2    Dawson, T.M.3
  • 32
    • 33344464009 scopus 로고    scopus 로고
    • Measurement of asymmetric dimethylarginine (ADMA) in human plasma: From liquid chromatography estimation to liquid chromatography- mass spectrometry quantification
    • Martens-Lobenhoffer J, Bode-Boger SM: Measurement of asymmetric dimethylarginine (ADMA) in human plasma: From liquid chromatography estimation to liquid chromatography- mass spectrometry quantification. Eur J Clin Pharmacol 2006; 62:61-68.
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 61-68
    • Martens-Lobenhoffer, J.1    Bode-Boger, S.M.2
  • 34
    • 65249184373 scopus 로고    scopus 로고
    • Role of symmetric dimethylarginine in vascular damage by increasing ROS via store-operated calcium influx in monocytes
    • Schepers E, Glorieux G, Dhondt A, et al: Role of symmetric dimethylarginine in vascular damage by increasing ROS via store-operated calcium influx in monocytes. Nephrol Dial Transplant 2009; 24:1429-1435.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 1429-1435
    • Schepers, E.1    Glorieux, G.2    Dhondt, A.3
  • 35
    • 67349279132 scopus 로고    scopus 로고
    • Asymmetric and symmetric dimethylarginines are of similar predictive value for cardiovascular risk in the general population
    • Kiechl S, Lee T, Santer P, et al: Asymmetric and symmetric dimethylarginines are of similar predictive value for cardiovascular risk in the general population. Atherosclerosis 2009; 205:261-265.
    • (2009) Atherosclerosis , vol.205 , pp. 261-265
    • Kiechl, S.1    Lee, T.2    Santer, P.3
  • 36
    • 47749103303 scopus 로고    scopus 로고
    • Symmetric dimethylarginine is an independent predictor of intradialytic hypotension
    • Mangoni AA, Hewitson CL, Woodman RJ, et al: Symmetric dimethylarginine is an independent predictor of intradialytic hypotension. Am J Hypertens 2008; 21:955-959.
    • (2008) Am J Hypertens , vol.21 , pp. 955-959
    • Mangoni, A.A.1    Hewitson, C.L.2    Woodman, R.J.3
  • 37
    • 33746096538 scopus 로고    scopus 로고
    • L-Arginine supplementation in sepsis: Beneficial or harmful?
    • DOI 10.1097/01.ccx.0000235206.92697.bf, PII 0007519820060800000005
    • Kalil AC, Danner RL, Kalil AC, et al: L-Arginine supplementation in sepsis: Beneficial or harmful? Curr Opin Crit Care 2006; 12: 303-308. (Pubitemid 44078141)
    • (2006) Current Opinion in Critical Care , vol.12 , Issue.4 , pp. 303-308
    • Kalil, A.C.1    Danner, R.L.2
  • 39
    • 0028935349 scopus 로고
    • Early enteral administration of a formula (Impact) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients: Results of a multicenter, prospective, randomized, clinical trial
    • Bower RH, Cerra FB, Bershadsky B, et al: Early enteral administration of a formula (Impact) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients: Results of a multicenter, prospective, randomized, clinical trial. Crit Care Med 1995; 23:436-449.
    • (1995) Crit Care Med , vol.23 , pp. 436-449
    • Bower, R.H.1    Cerra, F.B.2    Bershadsky, B.3
  • 42
    • 0042279261 scopus 로고    scopus 로고
    • Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients
    • Heyland DK, Dhaliwal R, Drover JW, et al: Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. Jpn J Parenteral Enteral Nutrition 2003; 27:355-373. (Pubitemid 37022781)
    • (2003) Journal of Parenteral and Enteral Nutrition , vol.27 , Issue.5 , pp. 355-373
    • Heyland, D.K.1    Dhaliwal, R.2    Drover, J.W.3    Gramlich, L.4    Dodek, P.5
  • 43
    • 31844444125 scopus 로고    scopus 로고
    • Lysophosphatidylcholine- induced elevation of asymmetric dimethylarginine level by the NADPH oxidase pathway in endothelial cells
    • Jia SJ, Jiang DJ, Hu CP, et al: Lysophosphatidylcholine- induced elevation of asymmetric dimethylarginine level by the NADPH oxidase pathway in endothelial cells. Vascul Pharmacol 2006; 44:143-148.
    • (2006) Vascul Pharmacol , vol.44 , pp. 143-148
    • Jia, S.J.1    Jiang, D.J.2    Hu, C.P.3
  • 44
    • 67651111871 scopus 로고    scopus 로고
    • Protective effects of kaempferol against endothelial damage by an improvement in nitric oxide production and a decrease in asymmetric dimethylarginine level
    • Xiao HB, Jun-Fang, Lu XY, et al: Protective effects of kaempferol against endothelial damage by an improvement in nitric oxide production and a decrease in asymmetric dimethylarginine level. Eur J Pharmacol 2009; 616:213-222.
    • (2009) Eur J Pharmacol , vol.616 , pp. 213-222
    • Xiao, H.B.1    Jun-Fang Lu, X.Y.2
  • 45
    • 15344344426 scopus 로고    scopus 로고
    • Antioxidant nutrients: A systematic review of trace elements and vitamins in the critically ill patient
    • Heyland DK, Dhaliwal R, Suchner U, et al: Antioxidant nutrients: A systematic review of trace elements and vitamins in the critically ill patient. Intensive Care Med 2005; 31: 327-337.
    • (2005) Intensive Care Med , vol.31 , pp. 327-337
    • Heyland, D.K.1    Dhaliwal, R.2    Suchner, U.3
  • 47
    • 0032899615 scopus 로고    scopus 로고
    • Nitric oxide metabolism and breakdown
    • DOI 10.1016/S0005-2728(99)00020-1, PII S0005272899000201
    • Kelm M: Nitric oxide metabolism and breakdown. Biochim Biophys Acta 1999; 1411: 273-289. (Pubitemid 29221955)
    • (1999) Biochimica et Biophysica Acta - Bioenergetics , vol.1411 , Issue.2-3 , pp. 273-289
    • Kelm, M.1


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