Increased iNOS activity is essential for hepatic epithelial tight junction dysfunction in endotoxemic mice

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 286, Issue 1 49-1, 2004, Pages

  Han, Xiaonan ^a   Fink, Mitchell P ^a   Uchiyama, Takashi ^a   Yang, Runkuan ^a   Delude, Russell L ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b 616 Scaife Hall ^*  (United States)

Author keywords

Endotoxemia; Hyperbilirubinemia; Inducible nitric oxide synthase; Jaundice; Lipopolysaccharide; Multiple organ dysfunction syndrome

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; BILE ACID; BILIRUBIN GLUCURONIDE; CELL PROTEIN; DEXTRAN; ENDOTOXIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LYSINE DERIVATIVE; NITRIC OXIDE; OCCLUDIN; UNCLASSIFIED DRUG; ZONULA OCCLUDENS 1; ZONULA OCCLUDENS 2; ZONULA OCCLUDENS 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE SEVERITY; ENDOTOXEMIA; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; ESCHERICHIA COLI; HEPATOBILIARY SYSTEM; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; INFLAMMATION; LIVER; MALE; MOUSE; NONHUMAN; OBSTRUCTIVE JAUNDICE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEPSIS; TIGHT JUNCTION;

EID: 0347988212     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00231.2003     Document Type: Article

References (43)

1. Anderson JM. Leaky junctions and cholestasis: a tight correlation. Gastroenterology 110: 1662-1665, 1996.
2. Balda MS and Matter K. Transmembrane proteins of tight junctions. Semin Cell Devel Biol 11: 281-289, 2000.
3. Bolder U, Ton-Nu HT, Schteingart CD, Frick E, and Hofmann AF. Hepatocyte transport of bile acids and organic anions in endotoxemic rats: impaired uptake and secretion. Gastroenterology 112: 214-225, 1997.
4. Chavez A, Menconi MJ, Hodin RA, and Fink MP. Cytokine-induced epithelial hyperpermeability: role of nitric oxide. Crit Care Med 27: 2246-2251, 1999.
5. Cuzzocrea S, Mazzon E, De Sarro A, and Caputi AP. Role of free radicals and poly(ADP-ribose) synthetase in intestinal tight junction permeability. Mol Med 6: 766-778, 2000.
6. Deitch EA. Multiple organ failure: pathophysiology and potential future therapy. Ann Surg 216: 117-134, 1992.
7. Fanning AS, Jameson BJ, Jesaitis LA, and Anderson JM. The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton. J Biol Chem 273: 29745-29753, 1998.
8. Franson TR, LaBrecque DR, Buggy BP, Harris GJ, and Hoffmann RG. Serial bilirubin determinations as a prognostic marker in clinical infections. Am J Med Sci 297: 149-152, 1989.
9. Gonzalez HE, Eugenin EA, Garces G, Solis N, Pizarro M, Accatino L, and Saez JC. Regulation of hepatic connexins in cholestasis: possible involvement of Kupffer cells and inflammatory mediators. Am J Physiol Gastrointest Liver Physiol 282: G991-G1001, 2002.
10. Gonzalez-Mariscal L, Betanzos A, and Avila-Flores A. MAGUK proteins: structure and role in the tight junction. Semin Cell Devel Biol 11: 315-324, 2000.
11. Green RM, Beier D, and Gollan JL. Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology 111: 193-198, 1996.
12. .-dependent and independent changes in expression and localization of tight junction proteins in intestinal epithelial cells. Shock 19: 229-237, 2003.
13. Hanada S, Harada M, Koga H, Kawaguchi T, Taniguchi E, Kumashiro R, Ueno T, Ueno Y, Ishii M, Sakisaka S, and Sata M. Tumor necrosis factor-alpha and interferon-gamma directly impair epithelial barrier function in cultured mouse cholangiocytes. Liver Int 23: 3-11, 2003.
14. Kang KW, Pak YM, and Kim ND. Diethylmaleate and buthionine sulfoximine, glutathione-depleting agents, differentially inhibit expression of inducible nitric oxide synthase in endotoxemic mice. Nitric Oxide 3: 265-271, 1999.
15. Kawaguchi T, Sakisaka S, Harada M, Hanada S, Taniguchi E, Koga H, Sasatomi K, Tanikawa K, and Sata M. Endotoxin increases paracellular permeability of isolated rat hepatocyte couplets. Hepatology 20: 144-154, 2001.
16. Kawaguchi T, Sakisaka S, Mitsuyama K, Harada M, Koga H, Taniguchi E, Sasatomi K, Kimura R, Ueno T, Sawada N, Mori M, and Sata M. Cholestasis with altered structure and function of hepatocyte tight junction and decreased expression of canalicular multispecific organic anion transporter in a rat model of colitis. Hepatology 31: 1285-1295, 2000.
17. Kubes P. Nitric oxide modulates epithelial permeability in the feline small intestine. Am J Physiol Gastrointest Liver Physiol 262: G1138-G1142, 1992.
18. Lora L, Mazzon E, Martines D, Fries W, Muraca M, Martin A, d'Odorico A, Naccarato R, and Citi S. Hepatocyte tight-junctional permeability is increased in rat experimental colitis. Gastroenterology 113: 1347-1354, 1997.
19. MacMicking JD, Nathan C, Horn G, Chartrain N, Fletcher DS, Trumbauer M, Stevens K, Quia-wen X, Sokol K, Hutchinson N, Chen H, and Mudgett JS. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81: 641-650, 1995.
20. Mankertz J, Tavalali S, Schmitz H, Mankertz A, Riecken EO, Fromm M, and Schulzke JD. Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma. J Cell Sci 113: 2085-2090, 2000.
21. Mazzon E, Puzzolo D, Caputi AP, and Cuzzocrea S. Role of IL-10 in hepatocyte tight junction alteration in mouse model of experimental colitis. Mol Med 8: 353-366, 2002.
22. Menconi MJ, Unno N, Smith M, Aguirre DE, and Fink MP. The effect of nitric oxide donors on the permeability of cultured intestinal epithelial monolayers: role of superoxide, hydroxyl radical, and peroxynitrite. Biochim Biophys Acta 1425: 189-203, 1998.
23. Mishima S, Xu D, and Deitch EA. Increase in endotoxin-induced mucosal permeability is related to increased nitric oxide synthase activity using the Üssing chamber. Crit Care Med 27: 880-886, 1999.
24. Mishima S, Xu D, Lu Q, and Deitch EA. Bacterial translocation is inhibited in inducible nitric oxide synthase knockout mice after endotoxin challenge but not in a model of bacterial overgrowth. Arch Surg 132: 1190-1195, 1997.
25. Mitic LL and Anderson JM. Molecular architecture of tight junctions. Annu Rev Physiol 60: 121-142, 1998.
26. Moore WM, Webber RK, Jerome GM, Tjong FS, Misko TP, and Currie MG. L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J Med Chem 37: 3886-3888, 1994.
27. Moseley RH, Wang W, Takeda H, Lown K, Schick L, Ananthanarayanan M, and Suchy FJ. Effect of endotoxin on bile acid transport in rat liver: a potential model for sepsis-associated cholestasis. Am J Physiol Gastrointest Liver Physiol 271: G137-G146, 1996.
28. Nathanson MH, Gautam A, Ng OC, Bruck R, and Boyer JL. Hormonal regulation of paracellular permeability in isolated rat hepatocyte couplets. Am J Physiol Gastrointest Liver Physiol 262: G1079-G1086, 1992.
29. Nathanson MH, Rios-Velez L, Burgstahler AD, and Mennone A. Communication via gap junctions modulates bile secretion in the isolated perfused rat liver. Gastroenterology 116: 1176-1183, 1999.
30. Notterpek L, Roux KJ, Amici SA, Yazdanpour A, Rahner C, and Fletcher BS. Peripheral myelin protein 22 is a constituent of intercellular junctions in epithelia. Proc Natl Acad Sci USA 98: 14404-14409, 2001.
31. Rahner C, Stieger B, and Landmann L. Structure-function correlation of tight junctional impairment after intrahepatic and extrahepatic cholestasis in rat liver. Gastroenterology 110: 1564-1578, 1996.
32. Sakakibara A, Furuse M, Saitou M, Ando-Akatsuka Y, and Tsukita S. Possible involvement of phosphorylation of occludin in tight junction formation. J Cell Biol 137: 1393-1401, 1997.
33. Stolz DB, Zamora R, Vodovotz Y, Loughran PA, Billiar TR, Kim YM, Simmons RL, and Watkins SC. Peroxisomal localization of inducible nitric oxide synthase in hepatocytes. Hepatology 36: 81-93, 2002.
34. Takakuwa Y, Kokai Y, Sasaki K, Chiba H, Tobioka H, Mori M, and Sawada N. Bile canalicular barrier function and expression of tight-junctional molecules in rat hepatocytes during common bile duct ligation. Cell Tissue Res 307: 181-189, 2002.
35. Trauner M, Arrese M, Lee H, Boyer JL, and Karpen SJ. Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. J Clin Invest 101: 2092-2100, 1998.
36. Trauner M, Meier PJ, and Boyer JL. Molecular pathogenesis of cholestasis. N Engl J Med 339: 1217-1227, 1998.
37. Unno N, Hodin RA, and Fink MP. Acidic conditions exacerbate interferon-gamma-induced intestinal epithelial hyperpermeability: role of peroxynitrous acid. Crit Care Med 27: 1429-1436, 1999.
38. Unno N, Menconi MJ, Smith M, and Fink MP. Nitric oxide mediates interferon-gamma-induced hyperpermeability in cultured human intestinal epithelial monolayers. Crit Care Med 23: 1170-1176, 1995.
39. Unno N, Wang H, Menconi MJ, Tytgat SHAJ, Larkin V, Smith M, Morin MJ, Chavez A, Hodin RA, and Fink MP. Inhibition of inducible nitric oxide synthase ameliorates lipopolysaccharide-induced gut mucosal barrier dysfunction in rats. Gastroenterology 113: 1246-1257, 1997.
40. Utili R, Abernathy CO, and Zimmerman HJ. Studies on the effects of E. coli endotoxin on canalicular bile formation in the isolated perfused rat liver. J Lab Clin Med 89: 471-482, 1977.
41. Vincent JL, Angus DC, Artigas A, Kalil A, Basson BR, Jamal HH, Johnson G3, Bernard GR, and Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Study Group. Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med 31: 834-840, 2003.
42. Wachtel M, Bolliger MF, Ishihara H, Frei K, Bluethmann H, and Gloor SM. Down-regulation of occludin expression in astrocytes by tumour necrosis factor (TNF) is mediated via TNF type-1 receptor and nuclear factor-kappaB activation. J Neurochem 78: 155-162, 2001.
43. Youakim A and Ahdieh M. Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin. Am J Physiol Gastrointest Liver Physiol 276: G1279-G1288, 1999.