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Volumn 122, Issue 4, 2009, Pages 460-465

Effect of a conserved peptide derived from Kunitz domain of hepatitis B virus x protein on the cell cycle and apoptosis of HepG2 cells via the proteasome pathway

Author keywords

Apoptosis; Carcinoma; Hepatocellular; p97 valosin containing protein; Peptides; Proteasome; Ubiquitin

Indexed keywords

ADENOSINE TRIPHOSPHATASE; HEPATITIS B VIRUS X PROTEIN; PEPTIDASE; PROTEASOME; PROTEIN P97; LIPOPEPTIDE; NUCLEAR PROTEIN; P97 ATPASE; PAM LYS(0) ARG(1) PRO(2) PRO(3) GLY(4) PHE(5) SER(6) PRO(7) PHE(8) ARG(9) OH; PAM-LYS(0)-ARG(1)-PRO(2)-PRO(3)-GLY(4)-PHE(5)-SER(6)-PRO(7)-PHE(8)-ARG(9)-OH; TRANSACTIVATOR PROTEIN; VIRUS PROTEIN;

EID: 65649135452     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2009.04.0019     Document Type: Article
Times cited : (12)

References (32)
  • 1
    • 35748986141 scopus 로고    scopus 로고
    • Treatment of hepatitis B: The next five years
    • Heathcote EJ. Treatment of hepatitis B: the next five years. Clin Med 2007; 7: 472-477.
    • (2007) Clin Med , vol.7 , pp. 472-477
    • Heathcote, E.J.1
  • 2
    • 24344435917 scopus 로고    scopus 로고
    • Epidemiology and natural history of hepatitis B
    • McMahon BJ. Epidemiology and natural history of hepatitis B. Semin Liver Dis 2005; 25 Suppl 1: 3-8.
    • (2005) Semin Liver Dis , vol.25 , Issue.SUPPL. 1 , pp. 3-8
    • McMahon, B.J.1
  • 3
    • 33947413521 scopus 로고    scopus 로고
    • Enhancement of hepatitis B virus replication by the regulatory X protein in vitro and in vivo
    • Keasler VV, Hodgson AJ, Madden CR, Slagle BL. Enhancement of hepatitis B virus replication by the regulatory X protein in vitro and in vivo. J Virol 2007; 81: 2656-2662.
    • (2007) J Virol , vol.81 , pp. 2656-2662
    • Keasler, V.V.1    Hodgson, A.J.2    Madden, C.R.3    Slagle, B.L.4
  • 4
    • 0034753082 scopus 로고    scopus 로고
    • Hepatitis B virus X protein: A multifunctional viral regulator
    • Murakami S. Hepatitis B virus X protein: a multifunctional viral regulator. J Gastroenterol 2001; 36: 651-660.
    • (2001) J Gastroenterol , vol.36 , pp. 651-660
    • Murakami, S.1
  • 5
    • 33748288087 scopus 로고    scopus 로고
    • Molecular functions and biological roles of hepatitis B virus x protein
    • Tang H, Oishi N, Kaneko S, Murakami S. Molecular functions and biological roles of hepatitis B virus x protein. Cancer Sci 2006; 97: 977-983.
    • (2006) Cancer Sci , vol.97 , pp. 977-983
    • Tang, H.1    Oishi, N.2    Kaneko, S.3    Murakami, S.4
  • 6
    • 21744456053 scopus 로고    scopus 로고
    • Cytotoxic effects of a decoction of Nigella sativa, Hemidesmus indicus and Smilax glabra on human hepatoma HepG2 cells
    • Thabrew MI, Mitry RR, Morsy MA, Hughes RD. Cytotoxic effects of a decoction of Nigella sativa, Hemidesmus indicus and Smilax glabra on human hepatoma HepG2 cells. Life Sci 2005; 77: 1319-1330.
    • (2005) Life Sci , vol.77 , pp. 1319-1330
    • Thabrew, M.I.1    Mitry, R.R.2    Morsy, M.A.3    Hughes, R.D.4
  • 7
    • 0029986179 scopus 로고    scopus 로고
    • Proteasome complex as a potential cellular target of hepatitis B virus X protein
    • Huang J, Kwong J, Sun EC, Liang TJ. Proteasome complex as a potential cellular target of hepatitis B virus X protein. J Virol 1996; 70: 5582-5591.
    • (1996) J Virol , vol.70 , pp. 5582-5591
    • Huang, J.1    Kwong, J.2    Sun, E.C.3    Liang, T.J.4
  • 8
    • 0034685805 scopus 로고    scopus 로고
    • Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complex
    • Zhang Z, Torii N, Furusaka A, Malayaman N, Hu Z, Liang TJ. Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complex. J Biol Chem 2000; 275: 15157-15165.
    • (2000) J Biol Chem , vol.275 , pp. 15157-15165
    • Zhang, Z.1    Torii, N.2    Furusaka, A.3    Malayaman, N.4    Hu, Z.5    Liang, T.J.6
  • 9
    • 0025635889 scopus 로고
    • Assembly of the 26 S complex that degrades proteins ligated to ubiquitin is accompanied by the formation of ATPase activity
    • Armon T, Ganoth D, Hershko A. Assembly of the 26 S complex that degrades proteins ligated to ubiquitin is accompanied by the formation of ATPase activity. J Biol Chem 1990; 265: 20723-20726.
    • (1990) J Biol Chem , vol.265 , pp. 20723-20726
    • Armon, T.1    Ganoth, D.2    Hershko, A.3
  • 10
    • 0032816238 scopus 로고    scopus 로고
    • Hepatitis B virus X protein is both a substrate and a potential inhibitor of the proteasome complex
    • Hu Z, Zhang Z, Doo E, Coux O, Goldberg AL, Liang TJ. Hepatitis B virus X protein is both a substrate and a potential inhibitor of the proteasome complex. J Virol 1999; 73: 7231-7240.
    • (1999) J Virol , vol.73 , pp. 7231-7240
    • Hu, Z.1    Zhang, Z.2    Doo, E.3    Coux, O.4    Goldberg, A.L.5    Liang, T.J.6
  • 11
    • 0036240410 scopus 로고    scopus 로고
    • VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line
    • Asai T, Tomita Y, Nakatsuka S, Hoshida Y, Myoui A, Yoshikawa H, et al. VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line. Jpn J Cancer Res 2002; 93: 296-304.
    • (2002) Jpn J Cancer Res , vol.93 , pp. 296-304
    • Asai, T.1    Tomita, Y.2    Nakatsuka, S.3    Hoshida, Y.4    Myoui, A.5    Yoshikawa, H.6
  • 12
    • 4143075852 scopus 로고    scopus 로고
    • Expression level of valosin-containing protein (p97) is associated with prognosis of esophageal carcinoma
    • Yamamoto S, Tomita Y, Hoshida Y, Iizuka N, Kidogami S, Miyata H, et al. Expression level of valosin-containing protein (p97) is associated with prognosis of esophageal carcinoma. Clin Cancer Res 2004; 10: 5558-5565.
    • (2004) Clin Cancer Res , vol.10 , pp. 5558-5565
    • Yamamoto, S.1    Tomita, Y.2    Hoshida, Y.3    Iizuka, N.4    Kidogami, S.5    Miyata, H.6
  • 13
    • 0025635770 scopus 로고
    • X protein of hepatitis B virus resembles a serine protease inhibitor
    • Takada S, Koike K. X protein of hepatitis B virus resembles a serine protease inhibitor. Jpn J Cancer Res 1990; 81: 1191-1194.
    • (1990) Jpn J Cancer Res , vol.81 , pp. 1191-1194
    • Takada, S.1    Koike, K.2
  • 14
    • 0028089001 scopus 로고
    • Interaction of hepatitis B virus X protein with a serine protease, tryptase TL2 as an inhibitor
    • Takada S, Kido H, Fukutomi A, Mori T, Koike K. Interaction of hepatitis B virus X protein with a serine protease, tryptase TL2 as an inhibitor. Oncogene 1994; 9: 341-348.
    • (1994) Oncogene , vol.9 , pp. 341-348
    • Takada, S.1    Kido, H.2    Fukutomi, A.3    Mori, T.4    Koike, K.5
  • 15
    • 2442473827 scopus 로고    scopus 로고
    • Hepatitis B virus X protein (HBx)-induced apoptosis in HuH-7 cells: Influence of HBV genotype and basal core promoter mutations
    • Kanda T, Yokosuka O, Imazeki F, Yamada Y, Imamura T, Fukai K, et al. Hepatitis B virus X protein (HBx)-induced apoptosis in HuH-7 cells: influence of HBV genotype and basal core promoter mutations. Scand J Gastroenterol 2004; 39: 478-485.
    • (2004) Scand J Gastroenterol , vol.39 , pp. 478-485
    • Kanda, T.1    Yokosuka, O.2    Imazeki, F.3    Yamada, Y.4    Imamura, T.5    Fukai, K.6
  • 16
    • 24144444516 scopus 로고    scopus 로고
    • Radiosensitivity of human colon cancer cell enhanced by immunoliposomal docetaxel
    • Wang QW, Lu HL, Song CC, Liu H, Xu CG. Radiosensitivity of human colon cancer cell enhanced by immunoliposomal docetaxel. World J Gastroenterol 2005; 11: 4003-4007.
    • (2005) World J Gastroenterol , vol.11 , pp. 4003-4007
    • Wang, Q.W.1    Lu, H.L.2    Song, C.C.3    Liu, H.4    Xu, C.G.5
  • 17
    • 0029989855 scopus 로고    scopus 로고
    • FtsH (HflB) is an ATP-dependent protease selectively acting on SecY and some other membrane proteins
    • Akiyama Y, Kihara A, Tokuda H, Ito K. FtsH (HflB) is an ATP-dependent protease selectively acting on SecY and some other membrane proteins. J Biol Chem 1996; 271: 31196-31201.
    • (1996) J Biol Chem , vol.271 , pp. 31196-31201
    • Akiyama, Y.1    Kihara, A.2    Tokuda, H.3    Ito, K.4
  • 18
    • 9644253202 scopus 로고    scopus 로고
    • Identification of a cysteine residue important for the ATPase activity of C. elegans fidgetin homologue
    • Yakushiji Y, Yamanaka K, Ogura T. Identification of a cysteine residue important for the ATPase activity of C. elegans fidgetin homologue. FEBS Lett 2004; 578: 191-197.
    • (2004) FEBS Lett , vol.578 , pp. 191-197
    • Yakushiji, Y.1    Yamanaka, K.2    Ogura, T.3
  • 19
    • 0032812632 scopus 로고    scopus 로고
    • Human hepatitis B virus mutants: Significance of molecular changes
    • Chen WN, Oon CJ. Human hepatitis B virus mutants: significance of molecular changes. FEBS Lett 1999; 453: 237-242.
    • (1999) FEBS Lett , vol.453 , pp. 237-242
    • Chen, W.N.1    Oon, C.J.2
  • 20
    • 0028851737 scopus 로고
    • Disruption of the function of tumor-suppressor gene p53 by the hepatitis B virus X protein and hepatocarcinogenesis
    • Takada S, Tsuchida N, Kobayashi M, Koike K. Disruption of the function of tumor-suppressor gene p53 by the hepatitis B virus X protein and hepatocarcinogenesis. J Cancer Res Clin Oncol 1995; 121: 593-601.
    • (1995) J Cancer Res Clin Oncol , vol.121 , pp. 593-601
    • Takada, S.1    Tsuchida, N.2    Kobayashi, M.3    Koike, K.4
  • 21
    • 33646114053 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces apoptosis in hepatoma cells through inhibiting Bcl-xL expression
    • Miao J, Chen GG, Chun SY, Lai PP. Hepatitis B virus X protein induces apoptosis in hepatoma cells through inhibiting Bcl-xL expression. Cancer Lett 2006; 236: 115-124.
    • (2006) Cancer Lett , vol.236 , pp. 115-124
    • Miao, J.1    Chen, G.G.2    Chun, S.Y.3    Lai, P.P.4
  • 22
    • 38049102858 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces apoptosis and cell cycle deregulation through interfering with DNA repair and checkpoint responses
    • Chen HY, Tang NH, Lin N, Chen ZX, Wang XZ. Hepatitis B virus X protein induces apoptosis and cell cycle deregulation through interfering with DNA repair and checkpoint responses. Hepatol Res 2008; 38: 174-182.
    • (2008) Hepatol Res , vol.38 , pp. 174-182
    • Chen, H.Y.1    Tang, N.H.2    Lin, N.3    Chen, Z.X.4    Wang, X.Z.5
  • 23
    • 0034772221 scopus 로고    scopus 로고
    • Hepatitis B virus X protein in the proteasome of mammalian cells: Defining the targeting domain
    • Chen WN, Oon CJ, Goo KS. Hepatitis B virus X protein in the proteasome of mammalian cells: defining the targeting domain. Mol Biol Rep 2001; 28: 31-34.
    • (2001) Mol Biol Rep , vol.28 , pp. 31-34
    • Chen, W.N.1    Oon, C.J.2    Goo, K.S.3
  • 24
    • 0031026555 scopus 로고    scopus 로고
    • The hepatitis B virus X protein: The quest for a role in viral replication and pathogenesis
    • Seeger C. The hepatitis B virus X protein: the quest for a role in viral replication and pathogenesis. Hepatology 1997; 25: 496-498.
    • (1997) Hepatology , vol.25 , pp. 496-498
    • Seeger, C.1
  • 25
    • 16944366641 scopus 로고    scopus 로고
    • Nucleotidase activities of the 26 S proteasome and its regulatory complex
    • Hoffman L, Rechsteiner M. Nucleotidase activities of the 26 S proteasome and its regulatory complex. J Biol Chem 1996; 271: 32538-32545.
    • (1996) J Biol Chem , vol.271 , pp. 32538-32545
    • Hoffman, L.1    Rechsteiner, M.2
  • 26
    • 0026551489 scopus 로고
    • Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms
    • Kanayama HO, Tamura T, Ugai S, Kagawa S, Tanahashi N, Yoshimura T, et al. Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms. Eur J Biochem 1992; 206: 567-578.
    • (1992) Eur J Biochem , vol.206 , pp. 567-578
    • Kanayama, H.O.1    Tamura, T.2    Ugai, S.3    Kagawa, S.4    Tanahashi, N.5    Yoshimura, T.6
  • 27
    • 0027319343 scopus 로고
    • Purification and characterization of the 26S proteasome complex catalyzing ATP-dependent breakdown of ubiquitin-ligated proteins from rat liver
    • Ugai S, Tamura T, Tanahashi N, Takai S, Komi N, Chung CH, et al. Purification and characterization of the 26S proteasome complex catalyzing ATP-dependent breakdown of ubiquitin-ligated proteins from rat liver. J Biochem 1993; 113: 754-768.
    • (1993) J Biochem , vol.113 , pp. 754-768
    • Ugai, S.1    Tamura, T.2    Tanahashi, N.3    Takai, S.4    Komi, N.5    Chung, C.H.6
  • 28
    • 0037427531 scopus 로고    scopus 로고
    • Hexamerization of p97-VCP is promoted by ATP binding to the D1 domain and required for ATPase and biological activities
    • Wang Q, Song C, Li CC. Hexamerization of p97-VCP is promoted by ATP binding to the D1 domain and required for ATPase and biological activities. Biochem Biophys Res Commun 2003; 300: 253-260.
    • (2003) Biochem Biophys Res Commun , vol.300 , pp. 253-260
    • Wang, Q.1    Song, C.2    Li, C.C.3
  • 29
    • 37349114505 scopus 로고    scopus 로고
    • Characterization of the aggregation-prevention activity of p97/valosin-containing protein
    • Song C, Wang Q, Li CC. Characterization of the aggregation-prevention activity of p97/valosin-containing protein. Biochemistry 2007; 46: 14889-14898.
    • (2007) Biochemistry , vol.46 , pp. 14889-14898
    • Song, C.1    Wang, Q.2    Li, C.C.3
  • 30
    • 0037423187 scopus 로고    scopus 로고
    • ATPase activity of p97-valosin-containing protein (VCP). D2 mediates the major enzyme activity, and D1 contributes to the heat-induced activity
    • Song C, Wang Q, Li CC. ATPase activity of p97-valosin-containing protein (VCP). D2 mediates the major enzyme activity, and D1 contributes to the heat-induced activity. J Biol Chem 2003; 278: 3648-3655.
    • (2003) J Biol Chem , vol.278 , pp. 3648-3655
    • Song, C.1    Wang, Q.2    Li, C.C.3
  • 31
    • 18544394748 scopus 로고    scopus 로고
    • RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis
    • Wójcik C, Yano M, DeMartino GN. RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis. J Cell Sci 2004; 117: 281-292.
    • (2004) J Cell Sci , vol.117 , pp. 281-292
    • Wójcik, C.1    Yano, M.2    DeMartino, G.N.3
  • 32
    • 14744283538 scopus 로고    scopus 로고
    • Expression level of valosin-containing protein (p97) is correlated with progression and prognosis of non-small-cell lung carcinoma
    • Yamamoto S, Tomita Y, Hoshida Y, Iizuka N, Monden M. Expression level of valosin-containing protein (p97) is correlated with progression and prognosis of non-small-cell lung carcinoma. Ann Surg Oncol 2004; 11: 697-704.
    • (2004) Ann Surg Oncol , vol.11 , pp. 697-704
    • Yamamoto, S.1    Tomita, Y.2    Hoshida, Y.3    Iizuka, N.4    Monden, M.5


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