메뉴 건너뛰기




Volumn 6, Issue 10, 2011, Pages

Thrombospondin1 deficiency reduces obesity-associated inflammation and improves insulin sensitivity in a diet-induced obese mouse model

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; THROMBOSPONDIN 1; PRIMER DNA;

EID: 80055039168     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026656     Document Type: Article
Times cited : (78)

References (43)
  • 1
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, Barnes GT, Yang Q, Tan G, Yang D, et al. (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112: 1821-1830.
    • (2003) J Clin Invest , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3    Tan, G.4    Yang, D.5
  • 2
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, et al. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112: 1796-1808.
    • (2003) J Clin Invest , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1    McCann, D.2    Desai, M.3    Rosenbaum, M.4    Leibel, R.L.5
  • 3
    • 36849005372 scopus 로고    scopus 로고
    • A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways
    • Nguyen MT, Favelyukis S, Nguyen AK, Reichart D, Scott PA, et al. (2007) A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem 282: 35279-35292.
    • (2007) J Biol Chem , vol.282 , pp. 35279-35292
    • Nguyen, M.T.1    Favelyukis, S.2    Nguyen, A.K.3    Reichart, D.4    Scott, P.A.5
  • 4
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng CN, Bodzin JL, Saltiel AR, (2007) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117: 175-184.
    • (2007) J Clin Invest , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 5
    • 0018253429 scopus 로고
    • Isolation and characterization of a high molecular weight glycoprotein from human blood platelets
    • Lawler JW, Slayter HS, Coligan JE, (1978) Isolation and characterization of a high molecular weight glycoprotein from human blood platelets. J Biol Chem 253: 8609-8616.
    • (1978) J Biol Chem , vol.253 , pp. 8609-8616
    • Lawler, J.W.1    Slayter, H.S.2    Coligan, J.E.3
  • 7
    • 0025083388 scopus 로고
    • Thrombospondin gene expression is associated with mitogenesis in 3T3 cells: induction by basic fibroblast growth factor
    • Donoviel DB, Amacher SL, Judge KW, Bornstein P, (1990) Thrombospondin gene expression is associated with mitogenesis in 3T3 cells: induction by basic fibroblast growth factor. J Cell Physiol 145: 16-23.
    • (1990) J Cell Physiol , vol.145 , pp. 16-23
    • Donoviel, D.B.1    Amacher, S.L.2    Judge, K.W.3    Bornstein, P.4
  • 8
    • 0032387693 scopus 로고    scopus 로고
    • Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial cells
    • Phelan MW, Forman LW, Perrine SP, Faller DV, (1998) Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial cells. J Lab Clin Med 132: 519-529.
    • (1998) J Lab Clin Med , vol.132 , pp. 519-529
    • Phelan, M.W.1    Forman, L.W.2    Perrine, S.P.3    Faller, D.V.4
  • 9
    • 0035049231 scopus 로고    scopus 로고
    • Thrombospondins as matricellular modulators of cell function
    • Bornstein P, (2001) Thrombospondins as matricellular modulators of cell function. J Clin Invest 107: 929-934.
    • (2001) J Clin Invest , vol.107 , pp. 929-934
    • Bornstein, P.1
  • 10
    • 0028790319 scopus 로고
    • Thrombospondin 1 is expressed by proliferating mesangial cells and is up-regulated by PDGF and bFGF in vivo
    • Hugo C, Pichler R, Meek R, Gordon K, Kyriakides T, et al. (1995) Thrombospondin 1 is expressed by proliferating mesangial cells and is up-regulated by PDGF and bFGF in vivo. Kidney Int 48: 1846-1856.
    • (1995) Kidney Int , vol.48 , pp. 1846-1856
    • Hugo, C.1    Pichler, R.2    Meek, R.3    Gordon, K.4    Kyriakides, T.5
  • 11
    • 0030965616 scopus 로고    scopus 로고
    • Cellular internalization and degradation of thrombospondin-1 is mediated by the amino-terminal heparin binding domain (HBD). High affinity interaction of dimeric HBD with the low density lipoprotein receptor-related protein
    • Mikhailenko I, Krylov D, Argraves KM, Roberts DD, Liau G, et al. (1997) Cellular internalization and degradation of thrombospondin-1 is mediated by the amino-terminal heparin binding domain (HBD). High affinity interaction of dimeric HBD with the low density lipoprotein receptor-related protein. J Biol Chem 272: 6784-6791.
    • (1997) J Biol Chem , vol.272 , pp. 6784-6791
    • Mikhailenko, I.1    Krylov, D.2    Argraves, K.M.3    Roberts, D.D.4    Liau, G.5
  • 12
    • 0034680794 scopus 로고    scopus 로고
    • Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin
    • Goicoechea S, Orr AW, Pallero MA, Eggleton P, Murphy-Ullrich JE, (2000) Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin. J Biol Chem 275: 36358-36368.
    • (2000) J Biol Chem , vol.275 , pp. 36358-36368
    • Goicoechea, S.1    Orr, A.W.2    Pallero, M.A.3    Eggleton, P.4    Murphy-Ullrich, J.E.5
  • 13
    • 0034492232 scopus 로고    scopus 로고
    • Cell contact-dependent activation of alpha3beta1 integrin modulates endothelial cell responses to thrombospondin-1
    • Chandrasekaran L, He CZ, Al-Barazi H, Krutzsch HC, Iruela-Arispe ML, et al. (2000) Cell contact-dependent activation of alpha3beta1 integrin modulates endothelial cell responses to thrombospondin-1. Mol Biol Cell 11: 2885-2900.
    • (2000) Mol Biol Cell , vol.11 , pp. 2885-2900
    • Chandrasekaran, L.1    He, C.Z.2    Al-Barazi, H.3    Krutzsch, H.C.4    Iruela-Arispe, M.L.5
  • 14
    • 0342445431 scopus 로고    scopus 로고
    • Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1
    • Jimenez B, Volpert OV, Crawford SE, Febbraio M, Silverstein RL, et al. (2000) Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. Nat Med 6: 41-48.
    • (2000) Nat Med , vol.6 , pp. 41-48
    • Jimenez, B.1    Volpert, O.V.2    Crawford, S.E.3    Febbraio, M.4    Silverstein, R.L.5
  • 15
    • 0033605655 scopus 로고    scopus 로고
    • The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric Gi
    • Frazier WA, Gao AG, Dimitry J, Chung J, Brown EJ, et al. (1999) The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric Gi. J Biol Chem 274: 8554-8560.
    • (1999) J Biol Chem , vol.274 , pp. 8554-8560
    • Frazier, W.A.1    Gao, A.G.2    Dimitry, J.3    Chung, J.4    Brown, E.J.5
  • 16
    • 13844292108 scopus 로고    scopus 로고
    • Internalization but not binding of thrombospondin-1 to low density lipoprotein receptor-related protein-1 requires heparan sulfate proteoglycans
    • Wang S, Herndon ME, Ranganathan S, Godyna S, Lawler J, et al. (2004) Internalization but not binding of thrombospondin-1 to low density lipoprotein receptor-related protein-1 requires heparan sulfate proteoglycans. J Cell Biochem 91: 766-776.
    • (2004) J Cell Biochem , vol.91 , pp. 766-776
    • Wang, S.1    Herndon, M.E.2    Ranganathan, S.3    Godyna, S.4    Lawler, J.5
  • 17
    • 0024263694 scopus 로고
    • Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors
    • Lawler J, Weinstein R, Hynes RO, (1988) Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors. J Cell Biol 107: 2351-2361.
    • (1988) J Cell Biol , vol.107 , pp. 2351-2361
    • Lawler, J.1    Weinstein, R.2    Hynes, R.O.3
  • 18
    • 0023432864 scopus 로고
    • Interactions of thrombospondin with endothelial cells: receptor-mediated binding and degradation
    • Murphy-Ullrich JE, Mosher DF, (1987) Interactions of thrombospondin with endothelial cells: receptor-mediated binding and degradation. J Cell Biol 105: 1603-1611.
    • (1987) J Cell Biol , vol.105 , pp. 1603-1611
    • Murphy-Ullrich, J.E.1    Mosher, D.F.2
  • 19
    • 0023522649 scopus 로고
    • Thrombospondin-induced tumor cell migration: haptotaxis and chemotaxis are mediated by different molecular domains
    • Taraboletti G, Roberts DD, Liotta LA, (1987) Thrombospondin-induced tumor cell migration: haptotaxis and chemotaxis are mediated by different molecular domains. J Cell Biol 105: 2409-2415.
    • (1987) J Cell Biol , vol.105 , pp. 2409-2415
    • Taraboletti, G.1    Roberts, D.D.2    Liotta, L.A.3
  • 20
    • 0028073226 scopus 로고
    • Thrombospondin promotes chemotaxis and haptotaxis of human peripheral blood monocytes
    • Mansfield PJ, Suchard SJ, (1994) Thrombospondin promotes chemotaxis and haptotaxis of human peripheral blood monocytes. J Immunol 153: 4219-4229.
    • (1994) J Immunol , vol.153 , pp. 4219-4229
    • Mansfield, P.J.1    Suchard, S.J.2
  • 21
    • 52049083001 scopus 로고    scopus 로고
    • Thrombospondin 1 Promotes Tumor Macrophage Recruitment and Enhances Tumor Cell Cytotoxicity of Differentiated U937 Cells
    • Martin-Manso G, Galli S, Ridnour LA, Tsokos M, Wink DA, et al. (2008) Thrombospondin 1 Promotes Tumor Macrophage Recruitment and Enhances Tumor Cell Cytotoxicity of Differentiated U937 Cells. Cancer Res 68: 7090-7099.
    • (2008) Cancer Res , vol.68 , pp. 7090-7099
    • Martin-Manso, G.1    Galli, S.2    Ridnour, L.A.3    Tsokos, M.4    Wink, D.A.5
  • 22
    • 0033058508 scopus 로고    scopus 로고
    • Age-related expression of renal thrombospondin 1 mRNA in F344 rats: resemblance to diabetes-induced expression in obese Zucker rats
    • Olson BA, Day JR, Laping NJ, (1999) Age-related expression of renal thrombospondin 1 mRNA in F344 rats: resemblance to diabetes-induced expression in obese Zucker rats. Pharmacology 58: 200-208.
    • (1999) Pharmacology , vol.58 , pp. 200-208
    • Olson, B.A.1    Day, J.R.2    Laping, N.J.3
  • 23
    • 0036867977 scopus 로고    scopus 로고
    • Carboxypeptidase E and thrombospondin-1 are differently expressed in subcutaneous and visceral fat of obese subjects
    • Ramis JM, Franssen-van Hal NL, Kramer E, Llado I, Bouillaud F, et al. (2002) Carboxypeptidase E and thrombospondin-1 are differently expressed in subcutaneous and visceral fat of obese subjects. Cell Mol Life Sci 59: 1960-1971.
    • (2002) Cell Mol Life Sci , vol.59 , pp. 1960-1971
    • Ramis, J.M.1    Franssen-van Hal, N.L.2    Kramer, E.3    Llado, I.4    Bouillaud, F.5
  • 25
    • 0037157110 scopus 로고    scopus 로고
    • Isolation of up- or down-regulated genes in PPARgamma-expressing NIH-3T3 cells during differentiation into adipocytes
    • Okuno M, Arimoto E, Nishizuka M, Nishihara T, Imagawa M, (2002) Isolation of up- or down-regulated genes in PPARgamma-expressing NIH-3T3 cells during differentiation into adipocytes. FEBS Lett 519: 108-112.
    • (2002) FEBS Lett , vol.519 , pp. 108-112
    • Okuno, M.1    Arimoto, E.2    Nishizuka, M.3    Nishihara, T.4    Imagawa, M.5
  • 26
    • 24944489186 scopus 로고    scopus 로고
    • Modulation of angiogenesis during adipose tissue development in murine models of obesity
    • Voros G, Maquoi E, Demeulemeester D, Clerx N, Collen D, et al. (2005) Modulation of angiogenesis during adipose tissue development in murine models of obesity. Endocrinology 146: 4545-4554.
    • (2005) Endocrinology , vol.146 , pp. 4545-4554
    • Voros, G.1    Maquoi, E.2    Demeulemeester, D.3    Clerx, N.4    Collen, D.5
  • 27
    • 40749150741 scopus 로고    scopus 로고
    • Thrombospondin-1 is an adipokine associated with obesity, adipose inflammation, and insulin resistance
    • Varma V, Yao-Borengasser A, Bodles AM, Rasouli N, Phanavanh B, et al. (2008) Thrombospondin-1 is an adipokine associated with obesity, adipose inflammation, and insulin resistance. Diabetes 57: 432-439.
    • (2008) Diabetes , vol.57 , pp. 432-439
    • Varma, V.1    Yao-Borengasser, A.2    Bodles, A.M.3    Rasouli, N.4    Phanavanh, B.5
  • 28
    • 78650415500 scopus 로고    scopus 로고
    • Thrombospondin-4 regulates vascular inflammation and atherogenesis
    • Frolova EG, Pluskota E, Krukovets I, Burke T, Drumm C, et al. (2010) Thrombospondin-4 regulates vascular inflammation and atherogenesis. Circ Res 107: 1313-1325.
    • (2010) Circ Res , vol.107 , pp. 1313-1325
    • Frolova, E.G.1    Pluskota, E.2    Krukovets, I.3    Burke, T.4    Drumm, C.5
  • 29
    • 37549022688 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • de Luca C, Olefsky JM, (2008) Inflammation and insulin resistance. FEBS Lett 582: 97-105.
    • (2008) FEBS Lett , vol.582 , pp. 97-105
    • de Luca, C.1    Olefsky, J.M.2
  • 30
    • 52749092267 scopus 로고    scopus 로고
    • Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals
    • Patsouris D, Li PP, Thapar D, Chapman J, Olefsky JM, et al. (2008) Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab 8: 301-309.
    • (2008) Cell Metab , vol.8 , pp. 301-309
    • Patsouris, D.1    Li, P.P.2    Thapar, D.3    Chapman, J.4    Olefsky, J.M.5
  • 31
    • 33750584214 scopus 로고    scopus 로고
    • TLR4 links innate immunity and fatty acid-induced insulin resistance
    • Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, et al. (2006) TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116: 3015-3025.
    • (2006) J Clin Invest , vol.116 , pp. 3015-3025
    • Shi, H.1    Kokoeva, M.V.2    Inouye, K.3    Tzameli, I.4    Yin, H.5
  • 32
    • 33644865243 scopus 로고    scopus 로고
    • Deficiency of thrombospondin-1 in mice does not affect adipose tissue development
    • Voros G, Lijnen HR, (2006) Deficiency of thrombospondin-1 in mice does not affect adipose tissue development. J Thromb Haemost 4: 277-278.
    • (2006) J Thromb Haemost , vol.4 , pp. 277-278
    • Voros, G.1    Lijnen, H.R.2
  • 35
    • 79955842992 scopus 로고    scopus 로고
    • Thrombospondin-1 Contributes to Mortality in Murine Sepsis through Effects on Innate Immunity
    • McMaken S, Exline MC, Mehta P, Piper M, Wang Y, et al. (2011) Thrombospondin-1 Contributes to Mortality in Murine Sepsis through Effects on Innate Immunity. PLoS One 6: e19654.
    • (2011) PLoS One , vol.6
    • McMaken, S.1    Exline, M.C.2    Mehta, P.3    Piper, M.4    Wang, Y.5
  • 37
    • 1642439096 scopus 로고    scopus 로고
    • Thrombospondin-1 is a major activator of TGF-beta in fibrotic renal disease in the rat in vivo
    • Daniel C, Wiede J, Krutzsch HC, Ribeiro SM, Roberts DD, et al. (2004) Thrombospondin-1 is a major activator of TGF-beta in fibrotic renal disease in the rat in vivo. Kidney Int 65: 459-468.
    • (2004) Kidney Int , vol.65 , pp. 459-468
    • Daniel, C.1    Wiede, J.2    Krutzsch, H.C.3    Ribeiro, S.M.4    Roberts, D.D.5
  • 38
    • 0028138619 scopus 로고
    • The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta
    • Schultz-Cherry S, Lawler J, Murphy-Ullrich JE, (1994) The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta. J Biol Chem 269: 26783-26788.
    • (1994) J Biol Chem , vol.269 , pp. 26783-26788
    • Schultz-Cherry, S.1    Lawler, J.2    Murphy-Ullrich, J.E.3
  • 39
    • 0027305971 scopus 로고
    • Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism
    • Schultz-Cherry S, Murphy-Ullrich JE, (1993) Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism. J Cell Biol 122: 923-932.
    • (1993) J Cell Biol , vol.122 , pp. 923-932
    • Schultz-Cherry, S.1    Murphy-Ullrich, J.E.2
  • 40
    • 4444338819 scopus 로고    scopus 로고
    • Molecular interactions that confer latency to transforming growth factor-beta. J Biol Chem 279: 38032-38039
    • Young GD, Murphy-Ullrich JE, (2004) Molecular interactions that confer latency to transforming growth factor-beta. J Biol Chem 279: 38032-38039. Epub 32004 Jun 38018.
    • (2004) Epub 32004 Jun 38018
    • Young, G.D.1    Murphy-Ullrich, J.E.2
  • 41
    • 0033853610 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity
    • Alessi MC, Bastelica D, Morange P, Berthet B, Leduc I, et al. (2000) Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity. Diabetes 49: 1374-1380.
    • (2000) Diabetes , vol.49 , pp. 1374-1380
    • Alessi, M.C.1    Bastelica, D.2    Morange, P.3    Berthet, B.4    Leduc, I.5
  • 42
    • 0031000588 scopus 로고    scopus 로고
    • Elevated expression of transforming growth factor-beta in adipose tissue from obese mice
    • Samad F, Yamamoto K, Pandey M, Loskutoff DJ, (1997) Elevated expression of transforming growth factor-beta in adipose tissue from obese mice. Mol Med 3: 37-48.
    • (1997) Mol Med , vol.3 , pp. 37-48
    • Samad, F.1    Yamamoto, K.2    Pandey, M.3    Loskutoff, D.J.4
  • 43
    • 33746494910 scopus 로고    scopus 로고
    • Among inflammation and coagulation markers, PAI-1 is a true component of the metabolic syndrome
    • Mertens I, Verrijken A, Michiels JJ, Van der Planken M, Ruige JB, et al. (2006) Among inflammation and coagulation markers, PAI-1 is a true component of the metabolic syndrome. Int J Obes (Lond) 30: 1308-1314.
    • (2006) Int J Obes (Lond) , vol.30 , pp. 1308-1314
    • Mertens, I.1    Verrijken, A.2    Michiels, J.J.3    Van der Planken, M.4    Ruige, J.B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.