Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H

Journal of Medicinal Chemistry

Volumn 56, Issue 13, 2013, Pages 5436-5445

  Masaoka, Takashi ^a   Chung, Suhman ^a   Caboni, Pierluigi ^b   Rausch, Jason W ^a   Wilson, Jennifer A ^a   Taskent Sezgin, Humeyra ^a   Beutler, John A ^a   Tocco, Graziella ^b   Le Grice, Stuart F J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

5,6 DIMETHYL 2 (4 NITROPHENYL)THIENO[2,3 D]PYRIMIDIN 4(3H) ONE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; PROTEIN P51; PROTEIN P66; PYRIMIDINONE DERIVATIVE; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; IN VITRO STUDY; NONHUMAN; THERMOSTABILITY; VIRUS REPLICATION;

ANTIVIRAL AGENTS; DRUG RESISTANCE, VIRAL; ENZYME INHIBITORS; ENZYME STABILITY; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINONES; REVERSE TRANSCRIPTASE INHIBITORS; RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS; TEMPERATURE;

EID: 84880165792     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400405z     Document Type: Article

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