The three α1-adrenoceptor subtypes show different spatio-temporal mechanisms of internalization and ERK1/2 phosphorylation

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1833, Issue 10, 2013, Pages 2322-2333

  Perez Aso, M ^a   Segura, V ^a   Monto F ^a   Barettino, D ^b   Noguera, M A ^a   Milligan, G ^c   D'Ocon, P ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Adrenaline 1 receptors; Constitutive activity; ERK1 2; Internalization; PKC

Indexed keywords

8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; BETA ARRESTIN 2; CONCANAVALIN A; EPITOPE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHENYLEPHRINE; PRAZOSIN; PROTEIN KINASE C; SMALL INTERFERING RNA;

ARTICLE; CELL NUCLEUS; CELL STRAIN HEK293; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME KINETICS; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INTERNALIZATION; INTRACELLULAR SIGNALING; PRIORITY JOURNAL; RECEPTOR UPREGULATION; WESTERN BLOTTING;

Α(1) ADRENOCEPTOR; Α(1)-AR; Β(2) ADRENOCEPTOR; Β(2)-AR; ADRENALINE Α(1) RECEPTORS; ANGIOTENSIN RECEPTOR TYPE 1A; AT(1A)R; BMAX; BOVINE SERUM ALBUMIN; BSA; CONA; CONCANAVALIN A; CONSTITUTIVE ACTIVITY; DIMETHYL SULFOXIDE; DMSO; EGFR; EPIDERMAL GROWTH FACTOR RECEPTOR; ERK1/2; G-PROTEIN COUPLED RECEPTOR; G-PROTEIN-COUPLED RECEPTOR KINASE; GAPDH; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; GPCR; GRK; HEK; HUMAN EMBRYONIC KIDNEY; INTERNALIZATION; KREBS RINGER HEPES; KRH; MAPK; MAXIMUM NUMBER OF BINDING SITES; MITOGEN-ACTIVATED PROTEIN KINASE; PARATHYROID HORMONE RECEPTOR TYPE 1; PBST; PCR; PE; PHENYLEPHRINE; PHOSPHATE-BUFFERED SALINE WITH 0.1% TWEEN 20; PKA; PKC; POLYMERASE CHAIN REACTION; PRAZOSIN; PROTEIN KINASE A; PROTEIN KINASE C; PTHR; PZ;

ARRESTINS; BLOTTING, WESTERN; CELLS, CULTURED; CONCANAVALIN A; ENDOCYTOSIS; ENZYME INHIBITORS; HUMANS; IMMUNOENZYME TECHNIQUES; KIDNEY; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTEIN KINASE C; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ADRENERGIC, ALPHA-1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84880152494     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2013.06.013     Document Type: Article

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