Desensitization of the dopamine D1 and D2 receptor hetero-oligomer mediated calcium signal by agonist occupancy of either receptor

Molecular Pharmacology

Volumn 72, Issue 2, 2007, Pages 450-462

  So, Christopher H ^a   Verma, Vaneeta ^a   O'Dowd, Brian F ^a,b   George, Susan R ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; DOPAMINE 1 RECEPTOR; DOPAMINE 1 RECEPTOR STIMULATING AGENT; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR STIMULATING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 3; G PROTEIN COUPLED RECEPTOR KINASE 5; G PROTEIN COUPLED RECEPTOR KINASE 6; OLIGOMER; PHOSPHOLIPASE C; QUINPIROLE; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM DEPLETION; CALCIUM SIGNALING; COMPLEX FORMATION; CONTROLLED STUDY; DESENSITIZATION; DRUG EFFICACY; DRUG POTENCY; HUMAN; HUMAN CELL; INHIBITION KINETICS; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR OCCUPANCY; SECOND MESSENGER;

(R)-2,3,4,5-TETRAHYDRO-8-CHLORO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL; BENZAZEPINES; BETA-ADRENERGIC RECEPTOR KINASE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOPAMINE AGONISTS; EGTAZIC ACID; HUMANS; PROTEIN KINASE C; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2;

EID: 34547143286     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.107.034884     Document Type: Article

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