Membrane binding and insertion of a pHLIP peptide studied by all-atom molecular dynamics simulations

International Journal of Molecular Sciences

Volumn 14, Issue 7, 2013, Pages 14532-14549

  Deng, Yonghua ^a   Qian, Zhenyu ^a   Luo, Yin ^a   Zhang, Yun ^a   Mu, Yuguang ^b   Wei, Guanghong ^a  

^a FUDAN UNIVERSITY   (China)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

All atom molecular dynamics simulations; Membrane binding; Ph low insertion peptide (pHLIP); Ph triggered bilayer insertion; Zwitterionic POPC

Indexed keywords

BINDING PROTEIN; OLEOYLPALMITOYLLECITHIN; PH LOW INSERTION PEPTIDE; PHOSPHATIDYLCHOLINE; UNCLASSIFIED DRUG;

ACIDITY; ALKALINITY; ALPHA HELIX; AQUEOUS SOLUTION; ARTICLE; ATOM; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; HYDROPHILICITY; HYDROPHOBICITY; MEMBRANE BINDING; MEMBRANE STRUCTURE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN UNFOLDING; PROTON TRANSPORT; STATIC ELECTRICITY; SURFACE PROPERTY;

AMINO ACID SEQUENCE; HYDROGEN-ION CONCENTRATION; IONS; LIPID BILAYERS; MEMBRANE PROTEINS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PHOSPHATIDYLCHOLINES; PROTEIN BINDING; WATER;

EID: 84880107712     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms140714532     Document Type: Article

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