Structural transformation of the amyloidogenic core region of TDP-43 protein initiates its aggregation and cytoplasmic inclusion

Journal of Biological Chemistry

Volumn 288, Issue 27, 2013, Pages 19614-19624

  Jiang, Lei Lei ^a   Che, Mei Xia ^a   Zhao, Jian ^a   Zhou, Chen Jie ^a   Xie, Mu Yun ^b   Li, Hai Yin ^a   He, Jian Hua ^b   Hu, Hong Yu ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b SHANGHAI INSTITUTE OF APPLIED PHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMYOTROPHIC LATERAL SCLEROSIS; BIOPHYSICAL STUDIES; CYTOPLASMIC INCLUSION; DNA-BINDING PROTEIN; FRONTOTEMPORAL DEMENTIAS; MOLECULAR DETERMINANTS; STRUCTURAL TRANSFORMATION; THERAPEUTIC TARGETS;

BIOCHEMISTRY; BIOLOGY;

PROTEINS;

AMYLOID PROTEIN; TAR DNA BINDING PROTEIN;

ALPHA HELIX; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CELL INCLUSION; CONTROLLED STUDY; GENE DELETION; GENE MUTATION; GENETIC SUSCEPTIBILITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN AGGREGATION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

AGGREGATION; AMYLOID; AMYOTROPHIC LATERAL SCLEROSIS (LOU GEHRIG'S DISEASE); CIRCULAR DICHROISM (CD); FLUORESCENCE; HYDROPHOBIC PATCH; INCLUSION FORMATION; NMR; STRUCTURAL TRANSFORMATION; TDP-43;

AMYLOID; ANIMALS; CAENORHABDITIS ELEGANS; DNA-BINDING PROTEINS; DRUG DESIGN; HELA CELLS; HELIX-TURN-HELIX MOTIFS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INCLUSION BODIES; PROTEIN STRUCTURE, TERTIARY; TDP-43 PROTEINOPATHIES;

EID: 84880073331     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.463828     Document Type: Article

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