Up-regulation of ciliary neurotrophic factor in astrocytes by aspirin; Implications for remyelination in multiple sclerosis

Journal of Biological Chemistry

Volumn 288, Issue 25, 2013, Pages 18533-18545

  Modi, Khushbu K ^a   Sendtner, Michael ^b   Pahan, Kalipada ^a,c  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c JESSE BROWN VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CILIARY NEUROTROPHIC FACTORS; MULTIPLE SCLEROSIS; REMYELINATION; THERAPEUTIC BENEFITS; UP-REGULATION;

BIOCHEMISTRY; BIOLOGY;

NEUROLOGY;

ACETYLSALICYLIC ACID; CILIARY NEUROTROPHIC FACTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MYELIN ASSOCIATED GLYCOPROTEIN; PROTEIN KINASE C; PROTEOLIPID PROTEIN; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; CELL PROTECTION; CILIARY NEUROTROPHIC FACTOR GENE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; FETUS; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; MULTIPLE SCLEROSIS; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REMYELINIZATION; UPREGULATION;

ASTROCYTES; CELL DEATH; CNTF; CREB; OLIGODENDROCYTES; PROTEIN KINASE A (PKA);

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; ASPIRIN; ASTROCYTES; CELLS, CULTURED; CILIARY NEUROTROPHIC FACTOR; CULTURE MEDIA, CONDITIONED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; HUMANS; IMMUNOBLOTTING; MICE; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MULTIPLE SCLEROSIS; MYELIN SHEATH; OLIGODENDROGLIA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84880071425     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.447268     Document Type: Article

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