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Volumn 288, Issue 27, 2013, Pages 19414-19428

Small molecule agonist of very late antigen-4 (VLA-4) integrin induces progenitor cell adhesion

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION RECEPTORS; CELL-BASED THERAPY; CROSS-REACTIVITY; LIGAND-BINDING SITES; STEM CELL THERAPY; STRUCTURAL MODIFICATIONS; SUBUNIT INTERFACES; SYNTHESIS AND CHARACTERIZATIONS;

EID: 84880061008     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.479634     Document Type: Article
Times cited : (25)

References (54)
  • 6
    • 54149103668 scopus 로고    scopus 로고
    • Homing and engraftment of progenitor cells: A prerequisite for cell therapy
    • Chavakis, E., Urbich, C., and Dimmeler, S. (2008) Homing and engraftment of progenitor cells: a prerequisite for cell therapy. J. Mol. Cell. Cardiol. 45, 514-522
    • (2008) J. Mol. Cell. Cardiol , vol.45 , pp. 514-522
    • Chavakis, E.1    Urbich, C.2    Dimmeler, S.3
  • 7
    • 0026770377 scopus 로고
    • Integrins: Versatility, modulation, and signaling in cell adhesion
    • Hynes, R. O. (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69, 11-25
    • (1992) Cell , vol.69 , pp. 11-25
    • Hynes, R.O.1
  • 8
    • 0031459452 scopus 로고    scopus 로고
    • Platelet GPIIb/IIIa antagonists: The first anti-integrin receptor therapeutics
    • Coller, B. S. (1997) Platelet GPIIb/IIIa antagonists: the first anti-integrin receptor therapeutics. J. Clin. Invest. 100, S57-S60
    • (1997) J. Clin. Invest , vol.100
    • Coller, B.S.1
  • 10
    • 0037023363 scopus 로고    scopus 로고
    • Crystal structure of the extracellular segment of integrinαVβ3 in complex with an Arg-Gly-Asp ligand
    • Xiong, J. P., Stehle, T., Zhang, R., Joachimiak, A., Frech, M., Goodman, S. L., and Arnaout, M. A. (2002) Crystal structure of the extracellular segment of integrinαVβ3 in complex with an Arg-Gly-Asp ligand. Science 296, 151-155
    • (2002) Science , vol.296 , pp. 151-155
    • Xiong, J.P.1    Stehle, T.2    Zhang, R.3    Joachimiak, A.4    Frech, M.5    Goodman, S.L.6    Arnaout, M.A.7
  • 11
    • 0028986196 scopus 로고
    • Crystal structure of the A domain from the α subunit of integrin CR3 (CD11b/CD18)
    • Lee, J. O., Rieu, P., Arnaout, M. A., and Liddington, R. (1995) Crystal structure of the A domain from the α subunit of integrin CR3 (CD11b/CD18). Cell 80, 631-638
    • (1995) Cell , vol.80 , pp. 631-638
    • Lee, J.O.1    Rieu, P.2    Arnaout, M.A.3    Liddington, R.4
  • 12
    • 34247891506 scopus 로고    scopus 로고
    • Structural basis of integrin regulation and signaling
    • Luo, B. H., Carman, C. V., and Springer, T. A. (2007) Structural basis of integrin regulation and signaling. Annu. Rev. Immunol. 25, 619-647
    • (2007) Annu. Rev. Immunol , vol.25 , pp. 619-647
    • Luo, B.H.1    Carman, C.V.2    Springer, T.A.3
  • 17
    • 33845360924 scopus 로고    scopus 로고
    • LFA-1 and VLA-4 involved in human high proliferative potentialendothelial progenitor cells homing to ischemic tissue
    • Duan, H., Cheng, L., Sun, X., Wu, Y., Hu, L., Wang, J., Zhao, H., and Lu, G. (2006) LFA-1 and VLA-4 involved in human high proliferative potentialendothelial progenitor cells homing to ischemic tissue. Thromb. Haemost. 96, 807-815
    • (2006) Thromb. Haemost , vol.96 , pp. 807-815
    • Duan, H.1    Cheng, L.2    Sun, X.3    Wu, Y.4    Hu, L.5    Wang, J.6    Zhao, H.7    Lu, G.8
  • 18
    • 0026779726 scopus 로고
    • Role of β1 and β2 integrins in the adhesion of human CD34hi stem cells to bone marrow stroma
    • Teixidó, J., Hemler, M. E., Greenberger, J. S., and Anklesaria, P. (1992) Role of β1 and β2 integrins in the adhesion of human CD34hi stem cells to bone marrow stroma. J. Clin. Invest. 90, 358-367
    • (1992) J. Clin. Invest , vol.90 , pp. 358-367
    • Teixidó, J.1    Hemler, M.E.2    Greenberger, J.S.3    Anklesaria, P.4
  • 19
    • 33947727618 scopus 로고    scopus 로고
    • Fusion of human hematopoietic progenitor cells and murine cardiomyocytes is mediated by α4β1 integrin/vascular cell adhesion molecule-1 interaction
    • Zhang, S., Shpall, E., Willerson, J. T., and Yeh, E. T. (2007) Fusion of human hematopoietic progenitor cells and murine cardiomyocytes is mediated by α4β1 integrin/vascular cell adhesion molecule-1 interaction. Circ. Res. 100, 693-702
    • (2007) Circ. Res , vol.100 , pp. 693-702
    • Zhang, S.1    Shpall, E.2    Willerson, J.T.3    Yeh, E.T.4
  • 21
    • 9344255481 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1α plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury
    • Abbott, J. D., Huang, Y., Liu, D., Hickey, R., Krause, D. S., and Giordano, F. J. (2004) Stromal cell-derived factor-1α plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation 110, 3300-3305
    • (2004) Circulation , vol.110 , pp. 3300-3305
    • Abbott, J.D.1    Huang, Y.2    Liu, D.3    Hickey, R.4    Krause, D.S.5    Giordano, F.J.6
  • 29
    • 0038281344 scopus 로고    scopus 로고
    • Paxillin binding to the α4 integrin subunit stimulates LFA-1 (integrin αlβ2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2
    • Rose, D. M., Liu, S., Woodside, D. G., Han, J., Schlaepfer, D. D., and Ginsberg, M. H. (2003) Paxillin binding to the α4 integrin subunit stimulates LFA-1 (integrin αLβ2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2. J. Immunol. 170, 5912-5918
    • (2003) J. Immunol , vol.170 , pp. 5912-5918
    • Rose, D.M.1    Liu, S.2    Woodside, D.G.3    Han, J.4    Schlaepfer, D.D.5    Ginsberg, M.H.6
  • 30
    • 33645786523 scopus 로고    scopus 로고
    • Contrasting roles for domain 4 of VCAM-1 in the regulation of cell adhesion and soluble VCAM-1 binding to integrin α4β1
    • Woodside, D. G., Kram, R. M., Mitchell, J. S., Belsom, T., Billard, M. J., McIntyre, B. W., and Vanderslice, P. (2006) Contrasting roles for domain 4 of VCAM-1 in the regulation of cell adhesion and soluble VCAM-1 binding to integrin α4β1. J. Immunol. 176, 5041-5049
    • (2006) J. Immunol , vol.176 , pp. 5041-5049
    • Woodside, D.G.1    Kram, R.M.2    Mitchell, J.S.3    Belsom, T.4    Billard, M.J.5    McIntyre, B.W.6    Vanderslice, P.7
  • 34
    • 0344628802 scopus 로고    scopus 로고
    • Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster
    • Chen, J., Salas, A., and Springer, T. A. (2003) Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster. Nat. Struct. Biol. 10, 995-1001
    • (2003) Nat. Struct. Biol , vol.10 , pp. 995-1001
    • Chen, J.1    Salas, A.2    Springer, T.A.3
  • 35
    • 0027243763 scopus 로고
    • A high affinity conformational state on VLA integrin heterodimers induced by an anti-1 chain monoclonal antibody
    • Arroyo, A. G., García-Pardo, A., and Sánchez-Madrid, F. (1993) A high affinity conformational state on VLA integrin heterodimers induced by an anti-1 chain monoclonal antibody. J. Biol. Chem. 268, 9863-9868
    • (1993) J. Biol. Chem , vol.268 , pp. 9863-9868
    • Arroyo, A.G.1    García-Pardo, A.2    Sánchez-Madrid, F.3
  • 36
    • 0028909232 scopus 로고
    • Regulation of lymphocyte pseudopodia formation by triggering the integrin α4/β1
    • Szabo, M. C., Teague, T. K., and McIntyre, B. W. (1995) Regulation of lymphocyte pseudopodia formation by triggering the integrin α4/β1. J. Immunol. 154, 2112-2124
    • (1995) J. Immunol , vol.154 , pp. 2112-2124
    • Szabo, M.C.1    Teague, T.K.2    McIntyre, B.W.3
  • 38
    • 84863012638 scopus 로고    scopus 로고
    • Structural specializations of α(4)β(7), an integrin that mediates rolling adhesion
    • Yu, Y., Zhu, J., Mi, L. Z., Walz, T., Sun, H., Chen, J., and Springer, T. A. (2012) Structural specializations of α(4)β(7), an integrin that mediates rolling adhesion. J. Cell Biol. 196, 131-146
    • (2012) J. Cell Biol , vol.196 , pp. 131-146
    • Yu, Y.1    Zhu, J.2    Mi, L.Z.3    Walz, T.4    Sun, H.5    Chen, J.6    Springer, T.A.7
  • 39
    • 0028805249 scopus 로고
    • Critical amino acid residues for ligand binding are clustered in a predicted β-turn of the third N-terminal repeat in the integrin α4 and α5 subunits
    • Irie, A., Kamata, T., Puzon-McLaughlin, W., and Takada, Y. (1995) Critical amino acid residues for ligand binding are clustered in a predicted β-turn of the third N-terminal repeat in the integrin α4 and α5 subunits. EMBO J. 14, 5550-5556
    • (1995) EMBO J. , vol.14 , pp. 5550-5556
    • Irie, A.1    Kamata, T.2    Puzon-Mclaughlin, W.3    Takada, Y.4
  • 40
    • 0034629151 scopus 로고    scopus 로고
    • The α(4) integrin subunit Tyr 187) has a key role in α(4)β(7)-dependent cell adhesion
    • Ruiz-Velasco, N., Guerrero-Esteo, M., Briskin, M. J., and Teixidó, J. (2000) The α(4) integrin subunit Tyr(187) has a key role in α(4)β(7)-dependent cell adhesion. J. Biol. Chem. 275, 7052-7059
    • (2000) J. Biol. Chem , vol.275 , pp. 7052-7059
    • Ruiz-Velasco, N.1    Guerrero-Esteo, M.2    Briskin, M.J.3    Teixidó, J.4
  • 42
    • 0024292679 scopus 로고
    • Site-directed mutagenesis of the cell-binding domain of human fibronectin: Separable, synergis-tic sites mediate adhesive function
    • Obara, M., Kang, M. S., and Yamada, K. M. (1988) Site-directed mutagenesis of the cell-binding domain of human fibronectin: separable, synergis-tic sites mediate adhesive function. Cell 53, 649-657
    • (1988) Cell , vol.53 , pp. 649-657
    • Obara, M.1    Kang, M.S.2    Yamada, K.M.3
  • 43
    • 0030612147 scopus 로고    scopus 로고
    • α4 integrin binding interfaces on VCAM-1 and MAdCAM-1. Integrin binding footprints identify accessory binding sites that play a role in integrin specificity
    • Newham, P., Craig, S. E., Seddon, G. N., Schofield, N. R., Rees, A., Edwards, R. M., Jones, E. Y., and Humphries, M. J. (1997) α4 integrin binding interfaces on VCAM-1 and MAdCAM-1. Integrin binding footprints identify accessory binding sites that play a role in integrin specificity. J. Biol. Chem. 272, 19429-19440
    • (1997) J. Biol. Chem , vol.272 , pp. 19429-19440
    • Newham, P.1    Craig, S.E.2    Seddon, G.N.3    Schofield, N.R.4    Rees, A.5    Edwards, R.M.6    Jones, E.Y.7    Humphries, M.J.8
  • 44
    • 33644682826 scopus 로고    scopus 로고
    • Stabilization of the activated αmβ2 integrin by a small molecule inhibits leukocyte migration and recruitment
    • Björklund, M., Aitio, O., Stefanidakis, M., Suojanen, J., Salo, T., Sorsa, T., and Koivunen, E. (2006) Stabilization of the activated αMβ2 integrin by a small molecule inhibits leukocyte migration and recruitment. Biochemistry 45, 2862-2871
    • (2006) Biochemistry , vol.45 , pp. 2862-2871
    • Björklund, M.1    Aitio, O.2    Stefanidakis, M.3    Suojanen, J.4    Salo, T.5    Sorsa, T.6    Koivunen, E.7
  • 46
    • 34047128107 scopus 로고    scopus 로고
    • A simple, no-wash cell adhesion-based high throughput assay for the discovery of small molecule regulators of the integrin CD11b/CD18
    • Park, J. Y., Arnaout, M. A., and Gupta, V. (2007) A simple, no-wash cell adhesion-based high throughput assay for the discovery of small molecule regulators of the integrin CD11b/CD18. J. Biomol. Screen. 12, 406-417
    • (2007) J. Biomol. Screen , vol.12 , pp. 406-417
    • Park, J.Y.1    Arnaout, M.A.2    Gupta, V.3
  • 47
    • 0036219943 scopus 로고    scopus 로고
    • A 3D structure model of integrin α4β1 complex: I. Construction of a homology model of β1 and ligand binding analysis
    • You, T. J., Maxwell, D. S., Kogan, T. P., Chen, Q., Li, J., Kassir, J., Holland, G. W., and Dixon, R. A. (2002) A 3D structure model of integrin α4β1 complex: I. Construction of a homology model of β1 and ligand binding analysis. Biophys. J. 82, 447-457
    • (2002) Biophys. J. , vol.82 , pp. 447-457
    • You, T.J.1    Maxwell, D.S.2    Kogan, T.P.3    Chen, Q.4    Li, J.5    Kassir, J.6    Holland, G.W.7    Dixon, R.A.8
  • 48
    • 78649747986 scopus 로고    scopus 로고
    • Closed headpiece of integrin αiIbβ3 and its complex with an αiIbβ3-specific antagonist that does not induce opening
    • Zhu, J., Zhu, J., Negri, A., Provasi, D., Filizola, M., Coller, B. S., and Springer, T. A. (2010) Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening. Blood 116, 5050-5059
    • (2010) Blood , vol.116 , pp. 5050-5059
    • Zhu, J.1    Zhu, J.2    Negri, A.3    Provasi, D.4    Filizola, M.5    Coller, B.S.6    Springer, T.A.7
  • 50
    • 0027317052 scopus 로고
    • A novel cyclic pentapeptide inhibits α4β1 and α5β1 integrin-mediated cell adhesion
    • Nowlin, D. M., Gorcsan, F., Moscinski, M., Chiang, S. L., Lobl, T. J., and Cardarelli, P. M. (1993) A novel cyclic pentapeptide inhibits α4β1 and α5β1 integrin-mediated cell adhesion. J. Biol. Chem. 268, 20352-20359
    • (1993) J. Biol. Chem , vol.268 , pp. 20352-20359
    • Nowlin, D.M.1    Gorcsan, F.2    Moscinski, M.3    Chiang, S.L.4    Lobl, T.J.5    Cardarelli, P.M.6
  • 51
    • 0142026204 scopus 로고    scopus 로고
    • Therapeutic antagonists and conformational regulation of integrin function
    • Shimaoka, M., and Springer, T. A. (2003) Therapeutic antagonists and conformational regulation of integrin function. Nat. Rev. Drug Discov. 2, 703-716
    • (2003) Nat. Rev. Drug Discov , vol.2 , pp. 703-716
    • Shimaoka, M.1    Springer, T.A.2
  • 52
    • 4644342292 scopus 로고    scopus 로고
    • The binding sites for competitive antagonistic, allosteric antagonistic, and agonistic antibodies to the i domain of integrin LFA-1
    • Lu, C., Shimaoka, M., Salas, A., and Springer, T. A. (2004) The binding sites for competitive antagonistic, allosteric antagonistic, and agonistic antibodies to the I domain of integrin LFA-1. J. Immunol. 173, 3972-3978
    • (2004) J. Immunol , vol.173 , pp. 3972-3978
    • Lu, C.1    Shimaoka, M.2    Salas, A.3    Springer, T.A.4
  • 53
    • 0034903048 scopus 로고    scopus 로고
    • Very late antigen-5 and leukocyte functionassociated antigen-1 are critical for early stage hematopoietic progenitor cell homing
    • Asaumi, N., Omoto, E., Mahmut, N., Katayama, Y., Takeda, K., Shinagawa, K., and Harada, M. (2001) Very late antigen-5 and leukocyte functionassociated antigen-1 are critical for early stage hematopoietic progenitor cell homing. Ann. Hematol. 80, 387-392
    • (2001) Ann. Hematol , vol.80 , pp. 387-392
    • Asaumi, N.1    Omoto, E.2    Mahmut, N.3    Katayama, Y.4    Takeda, K.5    Shinagawa, K.6    Harada, M.7
  • 54
    • 0037105428 scopus 로고    scopus 로고
    • Acute thrombocytopenia after treatment with tirofiban or eptifibatide is associated with antibodies specific for ligand-occupied GPIIb/IIIa
    • Bougie, D. W., Wilker, P. R., Wuitschick, E. D., Curtis, B. R., Malik, M., Levine, S., Lind, R. N., Pereira, J., and Aster, R. H. (2002) Acute thrombocytopenia after treatment with tirofiban or eptifibatide is associated with antibodies specific for ligand-occupied GPIIb/IIIa. Blood 100, 2071-2076
    • (2002) Blood , vol.100 , pp. 2071-2076
    • Bougie, D.W.1    Wilker, P.R.2    Wuitschick, E.D.3    Curtis, B.R.4    Malik, M.5    Levine, S.6    Lind, R.N.7    Pereira, J.8    Aster, R.H.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.