Effect of ketotifen on oxidative stress of pancreatic beta cells of type 2 diabetic rats

Chinese Journal of Pharmacology and Toxicology

Volumn 27, Issue 3, 2013, Pages 385-390

  Chen, Zi Miao ^a   Ni, Lian Song ^a   Wang, Mei Rong ^a   Pan, Liang Liang ^a   Hu, Wan Li ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Diabetes mellitus; Ketotifen; Oxidative stress; Pancreatic beta cell; Type 2

Indexed keywords

CYTOCHROME C OXIDASE; FATTY ACID; GLUCOSE; INTERLEUKIN 6; KETOTIFEN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; SUCCINATE DEHYDROGENASE; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE DIET; CELL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; MALE; MITOCHONDRION; MORPHOMETRICS; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; RAT; STREPTOZOCIN DIABETES; TRANSMISSION ELECTRON MICROSCOPY;

EID: 84880059875     PISSN: 10003002     EISSN: None     Source Type: Journal    
DOI: 10.3867/j.issn.1000-3002.2013.03.014     Document Type: Article

References (22)

1. Wu RL, Anthes JC, Kreutner W, Harris AG, West RE Jr. Desloratadine inhibits constitutive and histamine-stimulated nuclear factor-kappaB activity consistent with inverse agonism at the histamine H1 Receptor[J]. Int Arch Allergy Immunol, 2004, 135(4):313-318. (Pubitemid 40082196)
2. Azadi L, Abbasi H, Deemeh MR, Tavalaee M, Arbabian M, Pilevarian AA, et al. Zaditen (Ketotifen), as mast cell blocker, improves sperm quality, chromatin integrity and pregnancy rate after varicocelectomy[J]. Int J Androl, 2011, 34(5 Pt 1):446-452.
3. O'Sullivan M. Therapeutic potential of ketotifen in irritable bowel syndrome (IBS) may involve changes in mast cells at sites beyond the rectum[J]. Gut, 2011, 60(3):423.
4. Monument MJ, Hart DA, Befus AD, Salo PT, Zhang M, Hildebrand KA. The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures[J]. Inflamm Res, 2012, 61(4):285-292.
5. Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, et al. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and-diabetes in mice[J]. Nat Med, 2009, 15(8):940-945.
6. Wang J, Shi GP. Mast cell stabilization: novel medication for obesity and diabetes[J]. Diabetes Metab Res Rev, 2011, 27(8):919-924.
7. Pi J, Collins S. Reactive oxygen species and uncoupling protein 2 in pancreatic β-cell function[J]. Diabetes Obes Metab, 2010, 12(Suppl 2):141-148.
8. Pi J, Zhang Q, Fu J, Woods CG, Hou Y, Corkey BE, et al. ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function[J]. Toxicol Appl Pharmacol, 2010, 244(1):77-83.
9. Kowluru A. Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons le*arnt from pharmacological and molecular biological approaches[J]. Biochem Pharmacol, 2011, 81(8):965-975.
10. Lu H, Koshkin V, Allister EM, Gyulkhandanyan AV, Wheeler MB. Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes[J]. Diabetes, 2010, 59(2):448-459.
11. Dave GS, Kalia K. Hyperglycemia induced oxidative stress in type-1 and type-2 diabetic patients with and without nephropathy[J]. Cell Mol Biol (Noisy-le-grand), 2007, 53(5):68-78. (Pubitemid 350164307)
12. Ma ZA. The role of peroxidation of mitochondrial membrane phospholipids in pancreatic β-cell failure[J]. Curr Diabetes Rev, 2012, 8(1):69-75.
13. Xing XH, Chen L, Song HX. The preventive effect of anti-asthma particles on inflammatory airway damage of model rats with asthma in remission stage[J]. Chin Pediatr Integr Tradit West Med, 2010, 2(1):49-51.
14. Giacco F, Brownlee M. Oxidative stress and diabetic complications[J]. Circ Res, 2010, 107(9):1058-1070.
15. Alberici LC, Vercesi AE, Oliveira HC. Mitochondrial energy metabolism and redox responses to hypertriglyceridemia[J]. J Bioenerg Biomembr, 2011, 43(1):19-23.
16. Kotani K, Sakane N. C-reactive protein and reactive oxygen metabolites in subjects with metabolic syndrome[J]. J Int Med Res, 2012, 40(3):1074-1081.
17. Zhang S, Liu J, Dragunow M, Cooper GJ. Fibrillogenic amylin evokes islet beta-cell apoptosis through linked activation of a caspase cascade and JNK1[J]. J Biol Chem, 2003, 278(52):52810-52819. (Pubitemid 38035879)
18. Wang J, Shi GP. Mast cell stabilization: novel medication for obesity and diabetes[J]. Diabetes Metab Res Rev, 2011, 27(8):919-924.
19. Majeed SK. Mast cell distribution in rats[J]. Arzneimittelforschung, 1994, 44(3):370-374. (Pubitemid 24102569)
20. Zhang J, Shi GP. Mast cells and metabolic syndrome[J]. Biochim Biophys Acta, 2012, 1822(1):14-20.
21. Caughey GH. Mast cell tryptases and chymases in inflammation and host defense[J]. Immunol Rev, 2007, 217:141-154. (Pubitemid 46718143)
22. Krishnaswamy G, Ajitawi O, Chi DS. The human mast cell: an overview[J]. Methods Mol Biol, 2006, 315:13-34.