IRF5, IRF8, and IRF7 in human pDCs - the good, the bad, and the insignificant?

European Journal of Immunology

Volumn 43, Issue 7, 2013, Pages 1693-1697

  Pelka, Karin ^a   Latz, Eicke ^a,b,c  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

Author keywords

Innate immunity; Interferon; IRF; pDC

Indexed keywords

BETA INTERFERON; DNA; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERFERON REGULATORY FACTOR 5; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 6;

ARTICLE; AUTOIMMUNITY; CPG ISLAND; GENE INDUCTION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; NEGATIVE FEEDBACK; PLASMACYTOID DENDRITIC CELL; POSITIVE FEEDBACK; PRIORITY JOURNAL; RNA INTERFERENCE;

INNATE IMMUNITY; INTERFERON; IRF; PDC;

DENDRITIC CELLS; HUMANS; INTERFERON REGULATORY FACTORS; INTERFERON-BETA; INTERLEUKIN-6; NF-KAPPA B P50 SUBUNIT;

EID: 84880010925     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201343739     Document Type: Article

References (40)

1. Isaacs, A. and Lindenmann, J., Virus interference. I. The interferon. Proc. R. Soc. Lond. B Biol. Sci. 1957. 147: 258-267.
2. Lennert, K. and Remmele, W., Measurement of the cell nucleus in the lymph node cells of man. II. Reticulum cells and endothelial cells. Acta Haematol. 1958. 20: 301-317.
3. Siegal, F. P., Kadowaki, N., Shodell, M., Fitzgerald-Bocarsly, P. A., Shah, K., Ho, S., Antonenko, S. et al., The nature of the principal type 1 interferon-producing cells in human blood. Science 1999. 284: 1835-1837.
4. Cella, M., Jarrossay, D., Facchetti, F., Alebardi, O., Nakajima, H., Lanzavecchia, A. and Colonna, M., Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat. Med. 1999. 5: 919-923.
5. Fitzgerald-Bocarsly, P., Dai, J. and Singh, S., Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history. Cytokine Growth Factor Rev. 2008. 19: 3-19.
6. Izaguirre, A., Comparative analysis of IRF and IFN-alpha expression in human plasmacytoid and monocyte-derived dendritic cells. J. Leukoc. Biol. 2003. 74: 1125-1138.
7. Ito, T., Kanzler, H., Duramad, O., Cao, W. and Liu, Y.-J., Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid predendritic cells. Blood 2006. 107: 2423-2431.
8. Kato, H., Sato, S., Yoneyama, M., Yamamoto, M., Uematsu, S., Matsui, K., Tsujimura, T. et al., Cell type-specific involvement of RIG-I in antiviral response. Immunity 2005. 23: 19-28.
9. Lee, H. K., Lund, J. M., Ramanathan, B., Mizushima, N. and Iwasaki, A., Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 2007. 315: 1398-1401.
10. Baccala, R., Kono, D. H. and Theofilopoulos, A. N., Interferons as pathogenic effectors in autoimmunity. Immunol. Rev. 2005. 204: 9-26.
11. Maeda, T., Murata, K., Fukushima, T., Sugahara, K., Tsuruda, K., Anami, M., Onimaru, Y. et al., A novel plasmacytoid dendritic cell line, CAL-1, established from a patient with blastic natural killer cell lymphoma. Int. J. Hematol. 2005. 81: 148-154.
12. Steinhagen, F., McFarland, A. P., Rodriguez, L. G., Tewary, P., Jarret, A., Savan, R. and Klinman, D. M., IRF-5 and NF-κB p50 co-regulate IFN-β and IL-6 expression in TLR9-stimulated human plasmacytoid dendritic cells. Eur. J. Immunol. 2013. 43: 1896-1906.
13. Steinhagen, F., Meyer, C., Tross, D., Gursel, M., Maeda, T., Klaschik, S. and Klinman, D. M., Activation of type I interferon-dependent genes characterizes the "core response" induced by CpG DNA. J. Leukoc. Biol. 2012. 92: 775-785.
14. Krieg, A. M., CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 2002. 20: 709-760.
15. Klinman, D. M., Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat. Rev. Immunol. 2004. 4: 249-259.
16. Honda, K., Ohba, Y., Yanai, H., Negishi, H., Mizutani, T., Takaoka, A., Taya, C. et al., Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 2005. 434: 1035-1040.
17. Honda, K. and Taniguchi, T., IRFs: master regulators of signalling by toll-like receptors and cytosolic pattern-recognition receptors. Nat. Rev. Immunol. 2006. 6: 644-658.
18. Tamura, T., Yanai, H., Savitsky, D. and Taniguchi, T., The IRF family transcription factors in immunity and oncogenesis. Annu. Rev. Immunol. 2008. 26: 535-584.
19. Mancl, M. E., Hu, G., Sangster-Guity, N., Olshalsky, S. L., Hoops, K., Fitzgerald-Bocarsly, P., Pitha, P. M. et al., Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function. J. Biol. Chem. 2005. 280: 21078-21090.
20. Paun, A., Reinert, J. T., Jiang, Z., Medin, C., Balkhi, M. Y., Fitzgerald, K. A. and Pitha, P. M., Functional characterization of murine interferon regulatory factor 5 (IRF-5) and its role in the innate antiviral response. J. Biol. Chem. 2008. 283: 14295-14308.
21. Akira, S. and Takeda, K., Toll-like receptor signalling. Nat. Rev. Immunol. 2004. 4: 499-511.
22. Honda, K., Yanai, H., Negishi, H., Asagiri, M., Sato, M., Mizutani, T., Shimada, N. et al., IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 2005. 434: 772-777.
23. Tailor, P., Tamura, T., Kong, H. J., Kubota, T., Kubota, M., Borghi, P., Gabriele, L. et al., The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8. Immunity 2007. 27: 228-239.
24. Scharton-Kersten, T., Contursi, C., Masumi, A., Sher, A. and Ozato, K., Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. J. Exp. Med. 1997. 186: 1523-1534.
25. Giese, N. A., Gabriele, L., Doherty, T. M., Klinman, D. M., Tadesse-Heath, L., Contursi, C., Epstein, S. L. et al., Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression. J. Exp. Med. 1997. 186: 1535-1546.
26. Tsujimura, H., Tamura, T., Kong, H. J., Nishiyama, A., Ishii, K. J., Klinman, D. M. and Ozato, K., Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells. J. Immunol. 2004. 172: 6820-6827.
27. Schiavoni, G., Mattei, F., Sestili, P., Borghi, P., Venditti, M., Morse, H. C., Belardelli, F. et al., ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8+dendritic cells. J. Exp. Med. 2002. 196: 1415-1425.
28. Tamura, T., Tailor, P., Yamaoka, K., Kong, H. J., Tsujimura, H., O'Shea, J. J., Singh, H. et al., IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. J. Immunol. 2005. 174: 2573-2581.
29. Purtha, W. E., Swiecki, M., Colonna, M., Diamond, M. S. and Bhattacharya, D., Spontaneous mutation of the Dock2 gene in Irf5-/- mice complicates interpretation of type I interferon production and antibody responses. Proc. Natl. Acad. Sci. USA 2012. 109: E898-E904.
30. Yasuda, K., Nündel, K., Watkins, A. A., Dhawan, T., Bonegio, R. G., Ubellacker, J. M., Marshak-Rothstein, A. et al., Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2. Int. Immunol. 2013. 25: 295-306.
31. Schoenemeyer, A., Barnes, B. J., Mancl, M. E., Latz, E., Goutagny, N., Pitha, P. M., Fitzgerald, K. A. et al., The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling. J. Biol. Chem. 2005. 280: 17005-17012.
32. Barnes, B. J., Moore, P. A. and Pitha, P. M., Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes. J. Biol. Chem. 2001. 276: 23382-23390.
33. Barnes, B. J., Field, A. E. and Pitha-Rowe, P. M., Virus-induced heterodimer formation betweenIRF-5 and IRF-7 modulates assembly of the IFNA enhanceosome in vivo and transcriptional activity of IFNA genes. J. Biol. Chem. 2003. 278: 16630-16641.
34. Li, P., Wong, J. J. Y., Sum, C., Sin, W. X., Ng, K. Q., Koh, M. B. C. and Chin, K. C., IRF8 and IRF3 cooperatively regulate rapid interferon- induction in human blood monocytes. Blood 2011. 117: 2847-2854.
35. Baccala, R., Gonzalez-Quintial, R., Blasius, A. L., Rimann, I., Ozato, K., Kono, D. H., Beutler, B. et al., Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus. Proc. Natl. Acad. Sci. USA 2013. 110: 2940-2945.
36. Feng, D., Yang, L., Bi, X., Stone, R. C., Patel, P. and Barnes, B. J., Irf5-deficient mice are protected from pristane-induced lupus via increased Th2 cytokines and alteredIgG class switching. Eur. J. Immunol. 2012. 42: 1477-1487.
37. -/- mice have an intrinsic defect in their response to pristane-induced lupus. J. Immunol. 2012. 189: 3741-3750.
38. Cham, C. M., Ko, K. and Niewold, T. B., Interferon regulatory factor 5 in the pathogenesis of systemic lupus erythematosus. Clin. Dev. Immunol. 2012. 2012: 1-11.
39. Salloum, R. and Niewold, T. B., Interferon regulatory factors in human lupus pathogenesis. Transl. Res. 2011. 157: 326-331.
40. Stone, R. C., Feng, D., Deng, J., Singh, S., Yang, L., Fitzgerald-Bocarsly, P., Eloranta, M.-L. et al., Interferon regulatory factor 5 activation in monocytes of systemic lupus erythematosus patients is triggered by circulating autoantigens independent of type I interferons. Arthritis Rheum. 2012. 64: 788-798.