The cryptophycin-tubulin ring structure indicates two points of curvature in the tubulin dimer

Biochemistry

Volumn 41, Issue 42, 2002, Pages 12662-12669

  Watts, Norman R ^a   Cheng, Naiqian ^a   West, Wendy ^b   Steven, Alasdair C ^a   Sackett, Dan L ^b  

^a NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL CHANGES;

CONFORMATIONS; CRYSTAL STRUCTURE; DIMERS; ELECTRON MICROSCOPY; IMAGE ANALYSIS; SEDIMENTATION; STATISTICAL METHODS;

BIOCHEMISTRY;

CRYPTOPHYCIN 1; CYCLOPEPTIDE; DIMER; TUBULIN; UNCLASSIFIED DRUG;

ALPHA CHAIN; ARTICLE; BETA CHAIN; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG BINDING; IMAGE ANALYSIS; LIGHT SCATTERING; MICROTUBULE; MITOSIS SPINDLE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; STATISTICAL ANALYSIS;

ANIMALS; BIOPOLYMERS; COMPUTATIONAL BIOLOGY; DEPSIPEPTIDES; DIMERIZATION; HYDROLYSIS; IMAGE ENHANCEMENT; LIGHT; MICROSCOPY, ELECTRON, SCANNING; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; PROTEIN SUBUNITS; RATS; SCATTERING, RADIATION; TRYPSIN; TUBULIN; ULTRACENTRIFUGATION;

EID: 0037159216     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi020430x     Document Type: Article

References (39)

1. Unger, E., Bohm, K. J., and Vater, W. (1990) Electron Microsc. Rev. 3, 355-395.
2. Diaz, J. F., Pantos, E., Bordas, J., and Andreu, J. M. (1994) J. Mol. Biol. 238, 214-223.
3. Nicholson, W. V., Lee, M., Downing, K. H., and Nogales, E. (1999) Cell Biochem. Biophys. 31, 175-183.
4. Nogales, E., Wolf, S. G., and Downing, K. H. (1998) Nature 391, 199-203.
5. Melki, R., Carlier, M. F., Pantaloni, D., and Timasheff, S. N. (1989) Biochemistry 28, 9143-9152.
6. Downing, K. H., and Nogales, E. (1998) Curr. Opin. Cell Biol. 10, 16-22.
7. Jordan, A., Hadfield, J. A., Lawrence, N. J., and McGown, A. T. (1998) Med. Res. Rev. 18, 259-296.
8. Hamel, E. (1992) Pharmacol. Ther. 55, 31-51.
9. Bai, R., Durso, N. A., Sackett, D. L., and Hamel, E. (1999) Biochemistry 38, 14302-14310.
10. Barbier, P., Gregoire, C., Devred, F., Sarrazin, M., and Peyrot, V. (2001) Biochemistry 40, 13510-13519.
11. Bai, R. L., Schwartz, R. E., Kepler, J. A., Pettit, G. R., and Hamel, E. (1996) Cancer Res. 56, 4398-4406.
12. Downing, K. H. (2000) Annu. Rev. Cell Dev. Biol. 16, 89-111.
13. Watts, N. R., Sackett, D. L., Ward, R. D., Miller, M. W., Wingfield, P. T., Stahl, S. S., and Steven, A. C. (2000) J. Cell Biol. 150, 349-360.
14. Sackett, D. L., Knipling, L., and Wolff, J. (1991) Protein Expression Purif. 2, 390-393.
15. Wolff, J., Knipling, L., and Sackett, D. L. (1996) Biochemistry 35, 5910-5920.
16. Sackett, D. L., and Varma, J. K. (1993) Biochemistry 32, 13560-13565.
17. Wall, J. S., Hainfeld, J. F., and Simon, M. N. (1998) in Methods in Cell Biology (Berrios, M., Ed.) pp 139-166, Academic Press, New York.
18. Trus, B. L., Kocsis, E., Conway, J. F., and Steven, A. C. (1996) J. Struct. Biol. 116, 61-67.
19. Cheng, N., Conway, J. F., Watts, N. R., Hainfeld, J. F., Joshi, V., Powell, R. D., Stahl, S. J., Wingfield, P. E., and Steven, A. C. (1999) J. Struct. Biol. 127, 169-176.
20. Metoz, F., and Wade, R. H. (1997) J. Struct. Biol. 118, 128-139.
21. Conway, J. F., and Steven, A. C. (1999) J. Struct. Biol. 128, 106-118.
22. Belnap, D. M., Filman, D. J., Trus, B. L., Cheng, N., Booy, F. P., Conway, J. F., Curry, S., Hiremath, C. N., Tsang, S. K., Steven, A. C., and Hogle, J. M. (2000) J. Virol. 74, 1342-1354.
23. Kocsis, E., Cerritelli, M. E., Trus, B. L., Cheng, N., and Steven, A. C. (1995) Ultramicroscopy 60, 219-228.
24. Unser, M., Steven, A. C., and Trus, B. L. (1986) Ultramicroscopy 19, 337-348.
25. Unser, M., Trus, B. L., and Steven, A. C. (1987) Ultramicroscopy 23, 39-52.
26. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. A47, 110-119.
27. Sackett, D. L. (1995) Biochemistry 34, 7010-7019.
28. Sackett, D. L., and Wolff, J. (1986) J. Biol. Chem. 261, 9070-9076.
29. Sackett, D. L., and Lippoldt, R. E. (1991) Biochemistry 30, 3511-3517.
30. Gigant, B., Curmi, P. A., Martin-Barbey, C., Charbaut, E., Lachkar, S., Lebeau, L., Siavoshian, S., Sobel, A., and Knossow, M. (2000) Cell 102, 809-816.
31. Heymann, J. B. (2001) J. Struct. Biol. 133, 156-169.
32. Vetter, I. R., and Wittinghofer, A. (2001) Science 294, 1299-1304.
33. Nogales, E., Whittaker, M., Milligan, R. A., and Downing, K. H. (1999) Cell 96, 79-88.
34. Jordan, M. A., Margolis, R. L., Himes, R. H., and Wilson, L. (1986) J. Mol. Biol. 187, 61-73.
35. Li, J., Gao, X., Ortega, J., Nazif, T., Joss, L., Bogyo, M., Steven, A. C., and Rechsteiner, M. (2001) EMBO J. 20, 3359-3369.
36. Singh, S. K., Rozycki, J., Ortega, J., Ishikawa, T., Lo, J., Steven, A. C., and Maurizi, M. R. (2001) J. Biol. Chem. 276, 29420-29429.
37. Ishikawa, T., Beuron, F., Kessel, M., Wickner, S., Maurizi, M. R., and Steven, A. C. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 4328-4333.
38. Moores, C. A., Yu, M., Guo, J., Beraud, C., Sakowicz, R., and Milligan, R. A. (2002) Mol. Cell 9, 903-909.
39. Panda, D., DeLuca, K., Williams, D., Jordan, M. A., and Wilson, L. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 9313-9318.