Zinc-induced modulation of SRSF6 activity alters Bim splicing to promote generation of the most potent apoptotic isoform BimS

FEBS Journal

Volumn 280, Issue 14, 2013, Pages 3313-3327

  Hara, Hirokazu ^a   Takeda, Tatsuya ^a   Yamamoto, Nozomi ^a   Furuya, Keisuke ^a   Hirose, Kazuya ^a   Kamiya, Tetsuro ^a   Adachi, Tetsuo ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

apoptosis; Bim; splicing; SRSF6; Zinc

Indexed keywords

CADMIUM; COBALT; COPPER; ZINC;

ALTERNATIVE RNA SPLICING; APOPTOSIS; ARTICLE; BIMEL GENE; BIML GENE; BIMS GENE; BINDING SITE; CONTROLLED STUDY; CROSS LINKING; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; EXON; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTOXICITY; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; ONCOGENE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; WESTERN BLOTTING;

APOPTOSIS; BIM; SPLICING; SRSF6; ZINC;

ALTERNATIVE SPLICING; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BASE SEQUENCE; BINDING SITES; CELL LINE, TUMOR; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS; RNA PRECURSORS; RNA-BINDING PROTEINS; TRANSCRIPTION, GENETIC; ZINC;

EID: 84879948802     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12318     Document Type: Article

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