BOD (Bcl-2-Related Ovarian Death Gene) Is an Ovarian BH3 Domain-Containing Proapoptotic Bcl-2 Protein Capable of Dimerization with Diverse Antiapoptotic Bcl-2 Members

Molecular Endocrinology

Volumn 12, Issue 9, 1998, Pages 1432-1440

  Hsu, Sheau Yu ^a   Lin, Patty ^a   Hsueh, Aaron J W ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRICETINAE; CRICETULUS GRISEUS; HUMAN HERPESVIRUS 4; MAMMALIA;

APOPTOSIS REGULATORY PROTEIN; BCL 2 BINDING PROTEIN, BIM; BCL-2-BINDING PROTEIN, BIM; CARRIER PROTEIN; MCL1 PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; ONCOPROTEIN; PROTEIN BCL 2; TUMOR PROTEIN;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL; APOPTOSIS; ARTICLE; CHEMISTRY; CHO CELL; DIMERIZATION; GENETICS; HAMSTER; HUMAN; METABOLISM; MOLECULAR GENETICS; RAT;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; CHO CELLS; CRICETINAE; DIMERIZATION; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RNA, MESSENGER;

EID: 0032161337     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.12.9.0166     Document Type: Article

References (48)

1. Thompson CB 1995 Apoptosis in the pathogenesis and treatment of disease. Science 267:1456-1462
2. Hsueh AJ, Eisenhauer K, Chun SY, Hsu SY, Billig H 1996 Gonadal cell apoptosis. Recent Prog Horm Res 51:433-455
3. Reed JC 1997 Cytochrome c: can live with it-can live without it. Cell 91:558-562
4. Horvitz HR, Shaham S, Hengartner MO 1994 The genetics of programmed cell death in the nematode Caenorhabditis elegans. Cold Spring Harbor Symp Quant Biol 59:377-385
5. Cleary ML, Smith SD, Sklar J 1986 Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell 47:19-28
6. Tsujimoto Y, Yunis J, Onorato-Showe L, Erikson J, Nowell PC, Croce CM 1984 Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation. Science 224:1403-1406
7. Strasser A, Huang DC, Vaux DL 1997 The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumorigenesis and resistance to chemotherapy. Biochim Biophys Acta 1333:F151-F178
8. White E 1996 Life, death, and the pursuit of apoptosis. Genes Dev 10:1-15
9. Oltvai ZN, Milliman CL, Korsmeyer SJ 1993 Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619
10. Chittenden T, Harrington EA, O'Connor R, Flemington C, Lutz RJ, Evan GI, Guild BC 1995 Induction of apoptosis by the Bcl-2 homologue Bak. Nature 374:733-736
11. Farrow SN, White JH, Martinou I, Raven T, Pun KT, Grinham CJ, Martinou JC, Brown R 1995 Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K. Nature 374:731-733
12. Kiefer MC, Brauer MJ, Powers VC, Wu JJ, Umansky SR, Tomei LD, Barr PJ 1995 Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature 374:736-739
13. Yang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ 1995 Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80:285-291
14. Han J, Sabbatini P, White E 1996 Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K. Mol Cell Biol 16:5857-5864
15. Wang K, Yin XM, Chao DT, Milliman CL, Korsmeyer SJ 1996 BID: a novel BH3 domain-only death agonist. Genes Dev 10:2859-2869
16. Inohara N, Ding L, Chen S, Nunez G 1997 Harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L). EMBO J 16:1686-1694
17. Imaizumi K, Tsuda M, Imai Y, Wanaka A, Takagi T, Tohyama M 1997 Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death. J Biol Chem 272:18842-18848
18. Hsu SY, Kaipia A, McGee E, Lomeli M, Hsueh AJW 1997 Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc Natl Acad Sci USA 94:12401-12406
19. O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DCS 1998 Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J 17:384-395
20. Veis DJ, Sorenson CM, Shutter JR, Korsmeyer SJ 1993 Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75:229-240
21. Knudson CM, Tung KS, Tourtellotte WG, Brown GA, Korsmeyer SJ 1995 Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270:96-99
22. Shindler KS, Latham CB, Roth KA 1997 Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice. J Neurosci 17:3112-3119
23. Sedlak TW, Oltvai ZN, Yang E, Wang K, Boise LH, Thompson CB, Korsmeyer SJ 1995 Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad Sci USA 92:7834-7838
24. Pan G, O'Rourke K, Dixit VM 1998 Caspase-9, bcl-XL, and apaf-1 form a ternary complex. J Biol Chem 273:5841-5845
25. Minn AJ, Velez P, Schendel SL, Liang H, Muchmore SW, Fesik SW, Fill M, Thompson CB 1997 Bcl-X(L) forms an ion channel in synthetic lipid membranes. Nature 385:353-357
26. Schendel SL, Xie Z, Montai MO, Matsuyama S, Montal M, Reed JC 1997 Channel formation by antiapoptotic protein Bcl-2. Proc Natl Acad Sci USA 94:5113-5118
27. Schlesinger PH, Gross A, Yin XM, Yamamoto K, Saito M, Waksman G, Korsmeyer SJ 1997 Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2. Proc Natl Acad Sci USA 94: 11357-11362
28. Antonsson B, Conti F, Ciavatta A, Montessuit S, Lewis S, Martinou I, Bernasconi L, Bernard A, Mermod JJ, Mazzei G, Maundrell K, Gambale F, Sadoul R, Martinou JC 1997 Inhibition of Bax channel-forming activity by Bcl-2. Science 277:370-372
29. Vander Heiden MG, Chandel NS, Williamson EK, Schumacker PT, Thompson CB 1997 Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell 91:627-737
30. Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ 1996 Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not Bcl-X. Cell 87:619-628
31. Hsu SY, Kaipia A, Zhu L, Hsueh AJ 1997 Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11. Mol Endocrinol 11:1858-1867
32. Hsu SY, Lai RJ, Finegold M, Hsueh AJ 1996 Targeted overexpression of Bcl-2 in ovaries of transgenic mice leads to decreased follicle apoptosis, enhanced folliculogenesis, and increased germ cell tumorigenesis. Endocrinology 137:4837-4843
33. Fields S, Song O 1989 A novel genetic system to detect protein-protein interactions. Nature 340:245-247
34. Xue D, Horvitz HR 1995 Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature 377:248-251
35. Clem RJ, Miller LK 1994 Control of programmed cell death by the baculovirus genes p35 and iap. Mol Cell Biol 14:5212-5222
36. Gibson L, Holmgreen SP, Huang DC, Bernard O, Copeland NG, Jenkins NA, Sutherland GR, Baker E, Adams JM, Cory S 1996 bcl-w, a novel member of the bcl-2 family, promotes cell survival. Oncogene 13:665-675
37. Muchmore SW, Sattler M, Liang H, Meadows RP, Harlan JE, Yoon HS, Nettesheim D, Chang BS, Thompson CB, Wong SL, Ng SL, Fesik SW 1996 X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature 381:335-341
38. Aritomi M, Kunishima N, Inohara N, Ishibashi Y, Ohta S, Morikawa K 1997 Crystal structure of rat Bcl-xL. Implications for the function of the Bcl-2 protein family. J Biol Chem 272:27886-27892
39. Sattler M, Liang H, Nettesheim D, Meadows RP, Harlan JE, Eberstadt M, Yoon HS, Shuker SB, Chang BS, Minn AJ, Thompson CB, Fesik SW 1997 Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Science 275:983-986
40. Chittenden T, Flemington C, Houghton AB, Ebb RG, Gallo GJ, Elangovan B, Chinnadurai G, Lutz RJ 1995 A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J 14:5589-5596
41. Hunter JJ, Parslow TG 1996 A peptide sequence from Bax that converts Bcl-2 into an activator of apoptosis. J Biol Chem 271:8521-8524
42. Zha J, Harada H, Osipov K, Jockel J, Waksman G, Korsmeyer SJ 1997 BH3 domain of BAD is required for heterodimerization with Bcl-XL and pro-apoptotic activity. J Biol Chem 272:24101-24104
43. Simonen M, Keller H, Heim J 1997 The BH3 domain of Bax is sufficient for interaction of Bax with itself and with other family members and it is required for induction of apoptosis. Eur J Biochem 249:85-91
44. Cosulich SC, Worrall V, Hedge PJ, Green S, Clarke PR 1997 Regulation of apoptosis by BH3 domains in a cell free system. Curr Biol 7:913-920
45. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME 1997 Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241
46. del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nunez G 1997 Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278:687-689
47. Ottilie S, Diaz JL, Home W, Chang J, Wang Y, Wilson G, Chang S, Weeks S, Fritz LC, Oltersdorf T 1997 Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant bcl-2 and bcl-xl proteins. J Biol Chem 272:30866-30872
48. Kelekar A, Chang BS, Harlan JE, Fesik SW, Thompson CB 1997 Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL. Mol Cell Biol 17:7040-7046