Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes

FEBS Journal

Volumn 280, Issue 14, 2013, Pages 3436-3450

  Horova, Vladimira ^a   Hradilova, Nada ^a   Jelinkova, Iva ^b   Koc, Michal ^a,d   Svadlenka, Jan ^a   Brazina, Jan ^a   Klima, Martin ^a,e   Slavik, Josef ^c   Hyrslova Vaculova, Alena ^b   Andera, Ladislav ^a  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^b INSTITUTE OF BIOPHYSICS   (Czech Republic)

^c VETERINARY RESEARCH INSTITUTE   (Czech Republic)

^d CHARLES UNIVERSITY   (Czech Republic)

^e DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

acidification; apoptosis; caspase 8; TRAIL; V ATPase

Indexed keywords

ACID LIPASE; ADENOSINE TRIPHOSPHATASE; BAFILOMYCIN A1; CASPASE 8; CASPASE 8 INHIBITOR; CASPASE 8 INHIBITOR FLIP; CONCANAMYCIN A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; SPHINGOLIPID; SPHINGOMYELIN PHOSPHODIESTERASE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR; UNCLASSIFIED DRUG;

ACIDIFICATION; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PERMEABILIZATION; CELL SURFACE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; INTERNALIZATION; MALE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ACIDIFICATION; APOPTOSIS; CASPASE-8; TRAIL; V-ATPASE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 8; CELL LINE, TUMOR; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; DOWN-REGULATION; ENDOSOMES; ENZYME ACTIVATION; HUMANS; HYDROGEN-ION CONCENTRATION; MACROLIDES; PROTEIN TRANSPORT; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SIGNAL TRANSDUCTION; SPHINGOLIPIDS; SPHINGOMYELIN PHOSPHODIESTERASE; TNF-RELATED APOPTOSIS-INDUCING LIGAND; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84879943833     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12347     Document Type: Article

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