Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 28, 2013, Pages 11379-11384

  Phillips, Aaron H ^a   Zhang, Yingnan ^a   Cunningham, Christian N ^a   Zhou, Lijuan ^a   Forrest, William F ^a   Liu, Peter S ^a   Steffek, Micah ^a   Lee, James ^a   Tam, Christine ^a   Helgason, Elizabeth ^a   Murray, Jeremy M ^a   Kirkpatrick, Donald S ^a   Fairbrother, Wayne J ^a   Corn, Jacob E ^a  

^a GENENTECH INC   (United States)

Author keywords

Computational design; Phage display; Protein dynamics; Protein Protein interactions; Ubiquitin signaling

Indexed keywords

DEUBIQUITINASE; ISOPROTEIN; PROTEASOME; UBIQUITIN; UNCLASSIFIED DRUG; USP14 DEUBIQUITINASE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL GROWTH; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; ENZYME SUBSTRATE; EUKARYOTIC CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; SIGNAL TRANSDUCTION; UBIQUITINATION; WILD TYPE;

COMPUTATIONAL DESIGN; PHAGE DISPLAY; PROTEIN DYNAMICS; PROTEIN-PROTEIN INTERACTIONS; UBIQUITIN SIGNALING;

AMINO ACID SEQUENCE; ENDOPEPTIDASES; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; UBIQUITIN;

EUKARYOTA;

EID: 84879923631     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1302407110     Document Type: Article

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