Oncogenic KRAS-induced interleukin-8 overexpression promotes cell growth and migration and contributes to aggressive phenotypes of non-small cell lung cancer

International Journal of Cancer

Volumn 130, Issue 8, 2012, Pages 1733-1744

  Sunaga, Noriaki ^a,b   Imai, Hisao ^a   Shimizu, Kimihiro ^c   Shames, David S ^b,d,e   Kakegawa, Seiichi ^c   Girard, Luc ^b,d   Sato, Mitsuo ^b,f   Kaira, Kyoichi ^a   Ishizuka, Tamotsu ^a   Gazdar, Adi F ^b,d   Minna, John D ^b,d   Mori, Masatomo ^a  

^a GUNMA UNIVERSITY   (Japan)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e GENENTECH INC   (United States)

^f NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

interleukin 8; KRAS; molecular target; non small cell lung cancer

Indexed keywords

CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; INTERLEUKIN 8; K RAS PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NEUTRALIZING ANTIBODY; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

AGED; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INVASION; CELL GROWTH; CELL MIGRATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; FEMALE; GENE; GENE EXPRESSION REGULATION; GENE MUTATION; GENE SILENCING; GERIATRIC PATIENT; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERLEUKIN 8 GENE; LUNG ADENOCARCINOMA; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; MIGRATION INHIBITION; MITOSIS INHIBITION; ONCOGENE K RAS; PHENOTYPE; PLEURA METASTASIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEX DIFFERENCE; SMOKING;

AGED; BUTADIENES; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMIDAZOLES; INTERLEUKIN-8; KAPLAN-MEIER ESTIMATE; LUNG NEOPLASMS; MALE; MUTATION; NITRILES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOTYPE; PYRIDINES; RAS PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA INTERFERENCE; SMOKING;

EID: 84055209996     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.26164     Document Type: Article

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