RBM5 as a putative tumor suppressor gene for lung cancer

Journal of Thoracic Oncology

Volumn 5, Issue 3, 2010, Pages 294-298

  Sutherland, Leslie C ^a,b,c   Wang, Ke ^d   Robinson, Andrew G ^a  

^a SUDBURY REGIONAL HOSPITAL   (Canada)

^b LAURENTIAN UNIVERSITY   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

^d JILIN UNIVERSITY   (China)

Author keywords

Apoptosis; Gene expression; LUCA 15; Lung cancer; RBM5; Tumor suppressor

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FAS ANTIGEN; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN RBM 5; RNA BINDING PROTEIN; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ALLELE; ALTERNATIVE RNA SPLICING; APOPTOSIS; ASCITES TUMOR; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER TRANSPLANTATION; CHROMOSOME 3; CHROMOSOME ABERRATION; DISEASE ASSOCIATION; DISEASE COURSE; DOWN REGULATION; ENZYME ACTIVATION; GENE ACTIVITY; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENE INACTIVATION; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENE OVEREXPRESSION; GENETIC CODE; HETEROZYGOSITY LOSS; HISTOLOGY; HUMAN; IMMUNE DEFICIENCY; IMMUNOHISTOCHEMISTRY; LUNG CANCER; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; NONHUMAN; NORTHERN BLOTTING; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RESEARCH; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHORT SURVEY; SIGNAL TRANSDUCTION; SMOKING; TUMOR BIOPSY; TUMOR SUPPRESSOR GENE; UPREGULATION; X CHROMOSOME INACTIVATION;

EID: 77649331985     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e3181c6e330     Document Type: Short Survey

References (41)

1. Lerman MI, Minna JD. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. Cancer Res 2000;60:6116-6133.
2. Kok K, Naylor SL, Buys CH. Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes. Adv Cancer Res 1997;71:27-92.
3. Ji L, Minna JD, Roth JA. 3p21.3 tumor suppressor cluster: prospects for translational applications. Future Oncol 2005;1:79-92.
4. Wistuba II, Behrens C, Virmani AK, et al. High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints. Cancer Res 2000;60: 1949-1960.
5. Wei MH, Latif F, Bader S, et al. Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG. Cancer Res 1996;56:1487-1492.
6. Sutherland LC, Edwards SE, Cable HC, et al. LUCA-15-encoded sequence variants regulate CD95-mediated apoptosis. Oncogene 2000;19: 3774-3781.
7. Rintala-Maki ND, Sutherland LC. LUCA-15/RBM5, a putative tumour suppressor, enhances multiple receptor-initiated death signals. Apoptosis 2004;9:475-484.
8. Rintala-Maki ND, Abrasonis V, Burd M, et al. Genetic instability of RBM5/LUCA-15/H37 in MCF-7 breast carcinoma sublines may affect susceptibility to apoptosis. Cell Biochem Funct 2004;22:307-313.
9. Mourtada-Maarabouni M, Sutherland LC, Williams GT. Candidate tumour suppressor LUCA-15 can regulate multiple apoptotic pathways. Apoptosis 2002;7:421-432.
10. Mourtada-Maarabouni M, Sutherland LC, Meredith JM, et al. Simultaneous acceleration of the cell cycle and suppression of apoptosis by splice variant delta-6 of the candidate tumour suppressor LUCA-15/ RBM5. Genes Cells 2003;8:109-119.
11. Sutherland LC, Lerman M, Williams GT, et al. LUCA-15 suppresses CD95-mediated apoptosis in Jurkat T cells. Oncogene 2001;20:2713-2719.
12. Sutherland LC, Lerman M, Williams GT, et al. LUCA-15 suppresses CD95-mediated apoptosis in Jurkat T cells. Oncogene 2004;23:629.
13. Oh JJ, Razfar A, Delgado I, et al. 3p21.3 tumor suppressor gene H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis. Cancer Res 2006;66:3419-3427.
14. Fushimi K, Ray P, Kar A, et al. Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5. Proc Natl Acad Sci USA 2008;105:15708-15713.
15. Bonnal S, Martinez C, Forch P, et al. RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition. Mol Cell 2008;32: 81-95.
16. Zabarovsky ER, Lerman MI, Minna JD. Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers. Oncogene 2002;21:6915-6935.
17. Oh JJ, West AR, Fishbein MC, et al. A candidate tumor suppressor gene, H37, from the human lung cancer tumor suppressor locus 3p21.3. Cancer Res 2002;62:3207-3213.
18. Ter Elst A, Hiemstra BE, van der Vlies P, et al. Functional analysis of lung tumor suppressor activity at 3p21.3. Genes Chromosomes Cancer 2006;45:1077-1093.
19. Viktorsson K, Lewensohn R. Apoptotic signaling pathways in lung cancer. J Thorac Oncol 2007;2:175-179.
20. Ji L, Roth JA. Tumor suppressor FUS1 signaling pathway. J Thorac Oncol 2008;3:327-330.
21. Agathanggelou A, Bieche I, A hmed-Choudhury J, et al. Identification of novel gene expression targets for the Ras association domain family 1 (RASSF1A) tumor suppressor gene in non-small cell lung cancer and neuroblastoma. Cancer Res 2003;63:5344-5351.
22. Castro-Rivera E, Ran S, Thorpe P, et al. Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect. Proc Natl Acad Sci USA 2004;101:11432-11437.
23. Carboni GL, Gao B, Nishizaki M, et al. CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity. Oncogene 2003;22:615-626.
24. Ramaswamy S, Ross KN, Lander ES, et al. A molecular signature of metastasis in primary solid tumors. Nat Genet 2003;33:49-54.
25. Qiu TH, Chandramouli GV, Hunter KW, et al. Global expression profiling identifies signatures of tumor virulence in MMTV-PyMTtransgenic mice: correlation to human disease. Cancer Res 2004;64: 5973-5981.
26. Senchenko VN, Liu J, Loginov W, et al. Discovery of frequent homozygous deletions in chromosome 3p21.3 LUCA and AP20 regions in renal, lung and breast carcinomas. Oncogene 2004;23:5719-5728.
27. Sekido Y, Ahmadian M, Wistuba II, et al. Cloning of a breast cancer homozygous deletion junction narrows the region of search for a 3p21.3 tumor suppressor gene. Oncogene 1998;16:3151-3157.
28. Oh JJ, Boctor BN, Jimenez CA, et al. Promoter methylation study of the H37/RBM5 tumor suppressor gene from the 3p21.3 human lung cancer tumor suppressor locus. Hum Genet 2008;123:55-64.
29. Timmer T, Terpstra P, van den Berg A, et al. A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3. Eur J Hum Genet 1999;7: 478-486.
30. Oh JJ, Koegel AK, Phan DT, et al. The two single nucleotide polymorphisms in the H37/RBM5 tumour suppressor gene at 3p21.3 correlated with different subtypes of non-small cell lung cancers. Lung Cancer 2007;58:7-14.
31. Toyooka S, Maruyama R, Toyooka KO, et al. Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer. Int J Cancer 2003;103:153-160.
32. Todd S, Franklin WA, Varella-Garcia M, et al. Homozygous deletions of human chromosome 3p in lung tumors. Cancer Res 1997; 57:1344-1352. (Pubitemid 27152561)
33. Rintala-Maki ND, Sutherland LC. Identification and characterisation of a novel antisense non-coding RNA from the RBM5 gene locus. Gene 2009;445:7-16.
34. Wang K, Ubriaco G, Sutherland LC. RBM6-RBM5 transcriptioninduced chimeras are differentially expressed in tumours. BMC Genomics 2007;8:348.
35. Gazdar AF, Shigematsu H, Herz J, et al. Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers? Trends Mol Med 2004;10: 481-486.
36. Edamatsu H, Kaziro Y, Itoh H. LUCA15, a putative tumour suppressor gene encoding an RNA-binding nuclear protein, is down-regulated in ras-transformed Rat-1 cells. Genes Cells 2000;5:849-858.
37. Canoz O, Ozkan M, Arsav V, et al. The role of c-erbB-2 expression on the survival of patients with small-cell lung cancer. Lung 2006; 184:267-272.
38. Hirsch FR, Franklin WA, Veve R, et al. HER2/neu expression in malignant lung tumors. Semin Oncol 2002;29:51-58.
39. Buttitta F, Barassi F, Fresu G, et al. Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: mutations are mainly present in adenocarcinomas with bronchioloalveolar features. Int J Cancer 2006;119:2586-2591.
40. Bae NC, Chae MH, Lee MH, et al. EGFR, ERBB2, and KRAS mutations in Korean non-small cell lung cancer patients. Cancer Genet Cytogenet 2007;173:107-113.
41. Rintala-Maki ND, Goard CA, Langdon CE, et al. Expression of RBM5- related factors in primary breast tissue. J Cell Biochem 2007;100:1440-1458.