A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P2

Pflugers Archiv European Journal of Physiology

Volumn 465, Issue 7, 2013, Pages 945-953

  Telezhkin, Vsevolod ^a,c   Thomas, Alison M ^b   Harmer, Stephen C ^b   Tinker, Andrew ^b   Brown, David A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Membrane currents; Phosphatidylinositol 4,5 bisphosphate (PIP2); Potassium channels

Indexed keywords

PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; POTASSIUM CHANNEL KCNQ2;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CONTROLLED STUDY; FEMALE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; ION CHANNEL GATING; KCNQ2 POTASSIUM CHANNEL; MOLECULAR SEQUENCE DATA; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS;

EID: 84879845707     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-012-1199-3     Document Type: Article

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