Role of K+ Channels in Regulating Spontaneous Activity in Detrusor Smooth Muscle In Situ in the Mouse Bladder

Journal of Urology

Volumn 181, Issue 5, 2009, Pages 2355-2365

  Hayase, Masa ^a   Hashitani, Hikaru ^a   Kohri, Kenjiro ^a   Suzuki, Hikaru ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

calcium channels; inbred BALB C; mice; muscle; muscle contraction; smooth; urinary bladder

Indexed keywords

CHARYBDOTOXIN; IBERIOTOXIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; TETRYLAMMONIUM;

ACTION POTENTIAL; AFTERHYPERPOLARIZATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLADDER CONTRACTION; CALCIUM CONDUCTANCE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DETRUSOR MUSCLE; FLUORESCENCE; IMAGING; MALE; MEMBRANE POTENTIAL; MOUSE; MUSCLE EXCITATION; NERVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REPOLARIZATION; SMOOTH MUSCLE CONTRACTILITY;

ACTION POTENTIALS; ANIMALS; APAMIN; CALCIUM CHANNELS; ELECTROPHYSIOLOGY; MALE; MICE; MICE, INBRED BALB C; MODELS, ANIMAL; MUSCLE CONTRACTION; MUSCLE, SMOOTH; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; SENSITIVITY AND SPECIFICITY; URINARY BLADDER;

EID: 64049085358     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2009.01.013     Document Type: Article

References (20)

1. Sibley G.N. A comparison of spontaneous and nerve-mediated activity in bladder muscle from man, pig and rabbit. J Physiol 354 (1984) 431
2. Brading A.F. A myogenic basis for the overactive bladder. Urology 50 (1997) 57
3. Hashitani H., Brading A.F., and Suzuki H. Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder. Br J Pharmacol 141 (2004) 183
4. 2+ signals in detrusor smooth muscles of the guinea-pig urinary bladder. J Physiol 559 (2004) 567
5. + channel. J Biol Chem 279 (2004) 36746
6. Thorneloe K.S., Meredith A.L., Knorn A.M., Aldrich R.W., and Nelson M.T. Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder. Am J Physiol Renal Physiol 289 (2005) F604
7. Herrera G.M., Pozo M.J., Zvara P., Petkov G.V., Bond C.T., Adelman J.P., et al. Urinary bladder instability induced by selective suppression of the murine small conductance calcium-activated potassium (SK3) channel. J Physiol 551 (2003) 893
8. + current. J Physiol 549 (2003) 65
9. Meng E., Young J.S., and Brading A.F. Spontaneous activity of mouse detrusor smooth muscle and the effects of the urothelium. Neurourol Urodyn 27 (2008) 79
10. Ji G., Barsotti R.J., Feldman M.E., and Kotlikoff M.I. Stretch-induced calcium release in smooth muscle. J Gen Physiol 119 (2002) 533
11. Hashitani H., and Brading A.F. Electrical properties of detrusor smooth muscles from the pig and human urinary bladder. Br J Pharmacol 140 (2003) 146
12. + channel regulates contractile activity of mouse urinary bladder smooth muscle. J Physiol 537 (2001) 443
13. Hashitani H., and Brading A.F. Ionic basis for the regulation of spontaneous excitation in detrusor smooth muscle cells of the guinea-pig urinary bladder. Br J Pharmacol 140 (2003) 159
14. + channels in mouse urinary bladder smooth muscle cells. Jpn J Pharmacol 84 (2000) 97
15. + channel 2 is the key functional component of SK channels in mouse urinary bladder. Am J Physiol Regul Integr Comp Physiol 294 (2008) R1737
16. + channels, SK3, in the interstitial cells of Cajal in the gastrointestinal tract. Am J Physiol Cell Physiol 281 (2001) C1727
17. Wu C., Sui G.P., and Fry C.H. Purinergic regulation of guinea pig suburothelial myofibroblasts. J Physiol 559 (2004) 231
18. Kubota Y., Hashitani H., Shirasawa N., Kojima Y., Sasaki S., Mabuchi Y., et al. Altered distribution of interstitial cells in the guinea pig bladder following bladder outlet obstruction. Neurourol Urodyn 27 (2008) 330
19. α1 subunit expression and function in human detrusor muscle. J Urol 167 (2002) 1881
20. Thorneloe K.S., and Nelson M.T. Properties of a tonically active, sodium-permeable current in mouse urinary bladder smooth muscle. Am J Physiol Cell Physiol 286 (2004) C1246