The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine

Human Molecular Genetics

Volumn 20, Issue 20, 2011, Pages 3997-4004

  Richards, Shane A ^a   Muter, Joanne ^a   Ritchie, Pamela ^a   Lattanzi, Giovanna ^b   Hutchison, Christopher J ^a  

^a DURHAM UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; DNA; ETOPOSIDE; REACTIVE OXYGEN METABOLITE;

AGED; ARTICLE; BIOACCUMULATION; CELL ASSAY; CELL GROWTH; CELL PROLIFERATION; CELL SELECTION; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; DRUG MECHANISM; FIBROBLAST; HUMAN; HUMAN CELL; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROGERIA;

ACETYLCYSTEINE; AGE FACTORS; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; CHILD; CONTRACTURE; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA REPAIR; ETOPOSIDE; FIBROBLASTS; HUMANS; HYDROGEN PEROXIDE; MALE; OXIDANTS; PROGERIA; REACTIVE OXYGEN SPECIES; SKIN ABNORMALITIES;

EID: 80053150156     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddr327     Document Type: Article

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