Effects of acute and chronic administration of fenproporex on DNA damage parameters in young and adult rats

Molecular and Cellular Biochemistry

Volumn 380, Issue 1-2, 2013, Pages 171-176

  Gonçalves, Cinara L ^a,b,c   Rezin, Gislaine T ^d   Ferreira, Gabriela K ^a,b,c   Jeremias, Isabela C ^a,b,c   Cardoso, Mariane R ^a,b,c   Valvassori, Samira S ^a,b,c   Munhoz, Bruna J P ^a   Borges, Gabriela D ^a   Bristot, Bruno N ^a   Leffa, Daniela D ^a   Andrade, Vanessa M ^a   Quevedo, João ^a,b,c   Streck, Emilio L ^a,b,c  

^a UNIVERSIDADE DO EXTREMO SUL CATARINENSE   (Brazil)

^b Health Sciences Unit   (Brazil)

^c Center of Excellence in Applied Neuroscience of Santa Catarina (NENASC)   (Brazil)

^d UNIVERSITY OF SOUTHERN SANTA CATARINA   (Brazil)

Author keywords

DNA damage; Fenproporex; Peripheral blood; Rats

Indexed keywords

DNA; FENPROPOREX;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; MALE; NONHUMAN; RAT;

AGE FACTORS; AMPHETAMINES; ANIMALS; COMET ASSAY; DNA; DNA DAMAGE; INJECTIONS, INTRAPERITONEAL; MALE; RATS; RATS, WISTAR; TIME FACTORS;

RATTUS;

EID: 84879793620     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1670-2     Document Type: Article

References (43)

1. Deitel M (2003) Overweight and obesity worldwide now estimated to involve 1.7 billion people. Obes Surg 13:329-330
2. World Health Organization (2006) Obesity and overweight. Media Center, Fact Sheet N-311
3. Kopelman PG (2000) Obesity as a medical problem. Nature 404:635-643
4. Halpern A, Mancini MC (2003) Treatment of obesity: an update on anti-obesity medications. Obes Rev 4:25-42
5. Bray GA, Tartaglia LA (2000) Medicinal strategies in the treatment of obesity. Nature 404:672-677
6. Bray GA (1993) Use and abuse of appetite-suppressant drugs in the treatment of obesity. Ann Intern Med 119:707-713
7. Cohen PA (2009) Imported fenproporex-based diet pills from Brazil: a report of two cases. J Gen Intern Med 24:430-433
8. Coutts RT, Nazarali AJ, Baker GB, Pasutto FM (1986) Metabolism and disposition of N-(2-cyanoethyl)-amphetamine (fenproporex) and amphetamine: study in the rat brain. Can J Physiol Pharmacol 64:724-728
9. Mattei R, Carlini EA (1996) A comparative study of the anorectic and behavioral effects of fenproporex on male and female rats. Braz J Med Biol Res 29:1025-1030
10. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG (2000) Central nervous system control of food intake. Nature 404:661-671
11. Pélissier-Alicot AL, Piercecchi-Marti MD, Bartoli C, Kuhlmann E, Coiffait PE, Sanvoisin A, Giocanti D, Léonetti G (2006) Abusive prescription of psychostimulants: a study of two cases. J Forensic Sci 51:407-410
12. Snyder RD, Green JW (2001) A review of the genotoxicity of marketed pharmaceuticals. Mutat Res 488:151-169
13. Krishna G, Hayashi M (2000) In vivo rodent micronucleus assay: protocol, conduct and data interpretation. Mutat Res 455:155-166
14. Gunter MJ, Leitzmann MF (2006) Obesity and colorectal cancer: epidemiology, mechanisms and candidate genes. J Nutr Biochem 17:145-156
15. Halford JCG (2006) Pharmacotherapy for obesity. Appetite 46:6-10
16. Rezin GT, Jeremias IC, Ferreira GK, Cardoso MR, Morais MO, Gomes LM, Martinello OB, Valvassori SS, Quevedo J, Streck EL (2011) Brain energy metabolism is activated after acute and chronic administration of fenproporex in young rats. Int J Dev Neurosci 29:937-942
17. Rezin GT, Scaini G, Ferreira GK, Cardoso MR, Gonçalves CL, Constantino LS, Deroza PF, Ghedim FV, Valvassori SS, Resende WR, Quevedo J, Zugno AI, Streck EL (2012) Inhibition of acetylcholinesterase activity in brain and behavioral analysis in adult rats after chronic administration of fenproporex. Metab Brain Dis 27:453-458
18. Singh NP, Mccoy MT, Tice RR, Schneider EL (1998) A simple technique for quantification of low levels of DNA damage in individual cells. Exp Cell Res 175:184-191
19. Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae Y, Rojas E, Ryu JC, Sasaki YF (2000) Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 35:206-221
20. Villela IV, Oliveira IM, Silva J, Henriques JAP (2006) DNA damage and repair in hemolymph cells of golden mussel (Limnoperna fortunei) exposed to environmental contaminants. Mutat Res 605:78-86
21. Collins AR (2004) The comet assay for DNA damage and repair: principles, applications, and limitations. Mol Biotechnol 26:249-261
22. Moreira CQ, Faria MJ, Moreira EG (2005) Behavioral neurotoxicity in adolescent and adult mice exposed to fenproporex during pregnancy. Human Exp Toxicol 24:403-408
23. Collins AR, Oscoz AA, Brunborg G, Gaivão I, Giovannelli L, Kruszewski M, Smith CC, Stetina R (2008) The comet assay: topical issues. Mutagenesis 23:143-151
24. Dusinska M, Collins AR (2008) The comet assay in human biomonitoring: gene-environment interactions. Mutagenesis 23:191-205
25. McKenna DJ, McKeown SR, McKelvey-Martin VJ (2008) Potential use of the comet assay in the clinical management of cancer. Mutagenesis 23:183-190
26. Wasson GR, McKelvey-Martin VJ, Downes CS (2008) The use of the comet assay in the study of human nutrition and cancer. Mutagenesis 23:153-162
27. Cody JT, Valtier S, Stillman S (1999) Amphetamine and fenproporex levels following multidose administration of fenproporex. J Anal Toxicol 23:187-194
28. Kraemer T, Theis GA, Weber AA (2000) Studies on the metabolism and toxicological detection of the amphetamine-like anorectic fenproporex in human urine by gas chromatography-mass spectrometry and fluorescence polarization immunoassay. J Chromatogr B 738:107-118
29. Bengel D, Isaacs KR, Heils A, Lesch KP, Murphy DL (1998) The appetite suppressant d-fenfluramine induces apoptosis in human serotonergic cells. Neuroreport 9:2989-2993
30. da Silva CJ, dos Santos JE, Satie Takahashi C (2010) An evaluation of the genotoxic and cytotoxic effects of the anti-obesity drugs sibutramine and fenproporex. Hum Exp Toxicol 29:187-197
31. Andreazza AC, Kauer-Sant'Anna M, Frey BN, Stertz L, Zanotto C, Ribeiro L, Giasson K, Valvassori SS, Réus GZ, Salvador M, Quevedo J, Gonçalves CA, Kapczinski F (2008) Effects of mood stabilizers on DNA damage in an animal model of mania. J Psychiatry Neurosci 33:516-524
32. El-Khamisy SF, Caldecott KW (2006) TDP1-dependent DNA single strand break repair and neurodegeneration. Mutagenesis 21:219-224
33. Emerit I (1994) Reactive oxygen species, chromosome mutation, and cancer: possible role of clastogenic factors in carcinogenesis. Free Radical Biol Med 16:99-109
34. Alvarenga TA, Andersen ML, Ribeiro DA, Araujo P, Hirotsu C, Costa JL, Battisti MC, Tufik S (2010) Single exposure to cocaine or ecstasy induces DNA damage in brain and other organs of mice. Addict Biol 15(1):96-99
35. Pereira P, Gianesini J, da Silva Barbosa C, Cassol GF, Von Borowski RG, Kahl VF, Cappelari SE, Picada JN (2009) Neurobehavioral and genotoxic parameters of duloxetine in mice using the inhibitory avoidance task and comet assay as experimental models. Pharmacol Res 59(1):57-61
36. Arnaiz SL, Coronel MF, Boveris A (1999) Nitric oxide, superoxide and hydrogen peroxide production in brain mitochondria after haloperidol treatment. Nitric Oxide 3:235-243
37. Frey BN, Valvassori SS, Gomes KM, Martins MR, Dal-Pizzol F, Kapczinski F, Quevedo J (2006) Increased oxidative stress in submitochondrial particles after chronic amphetamine exposure. Brain Res 1097:224-229
38. Frey BN, Valvassori SS, Réus GZ, Martins MR, Petronilho FC, Bardini K, Dal-Pizzol F, Kapczinski F, Quevedo J (2006) Effects of lithium and valproate on amphetamine-induced oxidative stress generation in an animal model of mania. J Psychiatry Neurosci 31:326-332
39. Halliwell B (1996) Free radicals, proteins and DNA: oxidative damage versus redox regulation. Biochem Soc Trans 24:1023-1027
40. Adam-Vizi V (2005) Production of reactive oxygen species in brain mitochondria: contribution by electron transport chain and non-electron transport chain sources. Antioxid Redox Signal 7:1140-1149
41. Navarro A, Boveris A (2007) The mitochondrial energy transduction system and the aging process. Am J Physiol Cell Physiol 292:670-686
42. Valvassori SS, Rezin GT, Ferreira CL, Moretti M, Gonçalves CL, Cardoso MR, Streck EL, Kapczinski F, Quevedo J (2010) Effects of mood stabilizers on mitochondrial respiratory chain activity in brain of rats treated with d-amphetamine. J Psychiatr Res 44:903-909
43. Frenzilli G, Ferrucci M, Giorgi FS, Blandini F, Nigro M, Ruggieri S, Murri L, Paparelli A, Fornai F (2007) DNA fragmentation and oxidative stress in the hippocampal formation: a bridge between 3,4-methylenedioxymethamphetamine (ecstasy) intake and long-lasting behavioral alterations. Behav Pharmacol 18(5-6):471-481 Aplicadas de Santa Catarina Tecnológico Medicina