-
2
-
-
64049099095
-
Thyroid hormone mimetics: Potential applications in atherosclerosis, obesity and type 2 diabetes
-
Baxter JD, Webb P 2009 Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes. Nat Rev Drug Discov 8:308-320
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 308-320
-
-
Baxter, J.D.1
Webb, P.2
-
3
-
-
22644432001
-
Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice
-
Johansson L, Rudling M, Scanlan TS, Lundåsen T, Webb P, Baxter J, Angelin B, Parini P 2005 Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc Natl Acad Sci USA 102:10297-10302
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 10297-10302
-
-
Johansson, L.1
Rudling, M.2
Scanlan, T.S.3
Lundåsen, T.4
Webb, P.5
Baxter, J.6
Angelin, B.7
Parini, P.8
-
4
-
-
34848827936
-
Targeting thyroid hormone receptor-β agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index
-
Erion MD, Cable EE, Ito BR, Jiang H, Fujitaki JM, Finn PD, Zhang BH, Hou J, Boyer SH, van Poelje PD, Linemeyer DL 2007 Targeting thyroid hormone receptor-β agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index. Proc Natl Acad Sci USA 104:15490-15495
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 15490-15495
-
-
Erion, M.D.1
Cable, E.E.2
Ito, B.R.3
Jiang, H.4
Fujitaki, J.M.5
Finn, P.D.6
Zhang, B.H.7
Hou, J.8
Boyer, S.H.9
Van Poelje, P.D.10
Linemeyer, D.L.11
-
5
-
-
77649284831
-
The liver-selective thyromimetic T-0681 influences reverse cholesterol transport and atherosclerosis development in mice
-
Tancevski I, Demetz E, Eller P, Duwensee K, Hoefer J, Heim C, Stanzl U, Wehinger A, Auer K, Karer R, Huber J, Schgoer W, Van Eck M, Vanhoutte J, Fievet C, Stellaard F, Rudling M, Patsch JR, Ritsch A 2010 The liver-selective thyromimetic T-0681 influences reverse cholesterol transport and atherosclerosis development in mice. PLoS ONE 5:e8722
-
(2010)
PLoS ONE
, vol.5
-
-
Tancevski, I.1
Demetz, E.2
Eller, P.3
Duwensee, K.4
Hoefer, J.5
Heim, C.6
Stanzl, U.7
Wehinger, A.8
Auer, K.9
Karer, R.10
Huber, J.11
Schgoer, W.12
Van Eck, M.13
Vanhoutte, J.14
Fievet, C.15
Stellaard, F.16
Rudling, M.17
Patsch, J.R.18
Ritsch, A.19
-
6
-
-
0031781333
-
Effects of L-triiodothyronine and the thyromimetic L-94901 on serum lipoprotein levels and hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and apo A-I gene expression
-
Ness GC, Lopez D, Chambers CM, Newsome WP, Cornelius P, Long CA, Harwood Jr HJ 1998 Effects of L-triiodothyronine and the thyromimetic L-94901 on serum lipoprotein levels and hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and apo A-I gene expression. Biochem Pharmacol 56: 121-129
-
(1998)
Biochem Pharmacol
, vol.56
, pp. 121-129
-
-
Ness, G.C.1
Lopez, D.2
Chambers, C.M.3
Newsome, W.P.4
Cornelius, P.5
Long, C.A.6
Harwood Jr., H.J.7
-
7
-
-
0027962698
-
Thyroid hormone rapidly induces hepatic LDL receptor mRNA levels in hypophysectomized rats
-
Ness GC, Zhao Z 1994 Thyroid hormone rapidly induces hepatic LDL receptor mRNA levels in hypophysectomized rats. Arch Biochem Biophys 315:199-202
-
(1994)
Arch Biochem Biophys
, vol.315
, pp. 199-202
-
-
Ness, G.C.1
Zhao, Z.2
-
8
-
-
17744387900
-
The thyroid hormone receptor-β-selective agonist GC-1 differentially affects plasma lipids and cardiac activity
-
Trost SU, Swanson E, Gloss B, Wang-Iverson DB, Zhang H, Volodarsky T, Grover GJ, Baxter JD, Chiellini G, Scanlan TS, Dillmann WH 2000 The thyroid hormone receptor-β-selective agonist GC-1 differentially affects plasma lipids and cardiac activity. Endocrinology 141:3057-3064
-
(2000)
Endocrinology
, vol.141
, pp. 3057-3064
-
-
Trost, S.U.1
Swanson, E.2
Gloss, B.3
Wang-Iverson, D.B.4
Zhang, H.5
Volodarsky, T.6
Grover, G.J.7
Baxter, J.D.8
Chiellini, G.9
Scanlan, T.S.10
Dillmann, W.H.11
-
9
-
-
1642505721
-
Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: Selective actions relative to 3,5,3′-triiodo-L-thyronine
-
Grover GJ, Egan DM, Sleph PG, Beehler BC, Chiellini G, Nguyen NH, Baxter JD, Scanlan TS 2004 Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3′-triiodo-L-thyronine. Endocrinology 145:1656-1661
-
(2004)
Endocrinology
, vol.145
, pp. 1656-1661
-
-
Grover, G.J.1
Egan, D.M.2
Sleph, P.G.3
Beehler, B.C.4
Chiellini, G.5
Nguyen, N.H.6
Baxter, J.D.7
Scanlan, T.S.8
-
10
-
-
0032743739
-
Genetic control of hepatic apoB-100 secretion in human apoB transgenic mouse strains
-
Voyiaziakis E, Ko C, O'Rourke SM, Huang LS 1999 Genetic control of hepatic apoB-100 secretion in human apoB transgenic mouse strains. J Lipid Res 40:2004-2012
-
(1999)
J Lipid Res
, vol.40
, pp. 2004-2012
-
-
Voyiaziakis, E.1
Ko, C.2
O'Rourke, S.M.3
Huang, L.S.4
-
11
-
-
0029797604
-
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
-
Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS, Goldstein JL 1996 Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest 98:1575-1584
-
(1996)
J Clin Invest
, vol.98
, pp. 1575-1584
-
-
Shimano, H.1
Horton, J.D.2
Hammer, R.E.3
Shimomura, I.4
Brown, M.S.5
Goldstein, J.L.6
-
12
-
-
33846889319
-
Highly sensitive quantification of 7ahydroxy-4-cholesten-3-one in human serum by LC-ESI-MS/MS
-
Honda A, Yamashita K, Numazawa M, Ikegami T, Doy M, Matsuzaki Y, Miyazaki H 2007 Highly sensitive quantification of 7ahydroxy-4-cholesten-3-one in human serum by LC-ESI-MS/MS. J Lipid Res 48: 458-464
-
(2007)
J Lipid Res
, vol.48
, pp. 458-464
-
-
Honda, A.1
Yamashita, K.2
Numazawa, M.3
Ikegami, T.4
Doy, M.5
Matsuzaki, Y.6
Miyazaki, H.7
-
13
-
-
0032520018
-
Regulation of expression of human intestinal bile acid-binding protein in Caco-2 cells
-
Kanda T, Foucand L, Nakamura Y, Niot I, Besnard P, Fujita M, Sakai Y, Hatakeyama K, Ono T, Fujii H 1998 Regulation of expression of human intestinal bile acid-binding protein in Caco-2 cells. Biochem J 330(Pt 1):261
-
(1998)
Biochem J
, vol.330
, Issue.PART 1
, pp. 261
-
-
Kanda, T.1
Foucand, L.2
Nakamura, Y.3
Niot, I.4
Besnard, P.5
Fujita, M.6
Sakai, Y.7
Hatakeyama, K.8
Ono, T.9
Fujii, H.10
-
14
-
-
0141571088
-
Inhibition of ileal bile acid transport and reduced atherosclerosis in apoE-/- mice by SC-435
-
Bhat BG, Rapp SR, Beaudry JA, Napawan N, Butteiger DN, Hall KA, Null CL, Luo Y, Keller BT 2003 Inhibition of ileal bile acid transport and reduced atherosclerosis in apoE-/- mice by SC-435. J Lipid Res 44:1614-1621
-
(2003)
J Lipid Res
, vol.44
, pp. 1614-1621
-
-
Bhat, B.G.1
Rapp, S.R.2
Beaudry, J.A.3
Napawan, N.4
Butteiger, D.N.5
Hall, K.A.6
Null, C.L.7
Luo, Y.8
Keller, B.T.9
-
15
-
-
0036733630
-
Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol
-
Yu L, Li-Hawkins J, Hammer RE, Berge KE, Horton JD, Cohen JC, Hobbs HH 2002 Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J Clin Invest 110:671-680
-
(2002)
J Clin Invest
, vol.110
, pp. 671-680
-
-
Yu, L.1
Li-Hawkins, J.2
Hammer, R.E.3
Berge, K.E.4
Horton, J.D.5
Cohen, J.C.6
Hobbs, H.H.7
-
16
-
-
41649089141
-
The organic solute transporterα-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis
-
Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA 2008 The organic solute transporterα-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis. Proc Natl Acad Sci USA 105:3891-3896
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 3891-3896
-
-
Rao, A.1
Haywood, J.2
Craddock, A.L.3
Belinsky, M.G.4
Kruh, G.D.5
Dawson, P.A.6
-
17
-
-
0037058995
-
Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion
-
Yu L, Hammer RE, Li-Hawkins J, Von Bergmann K, Lutjohann D, Cohen JC, Hobbs HH 2002 Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc Natl Acad Sci USA 99:16237-16242
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 16237-16242
-
-
Yu, L.1
Hammer, R.E.2
Li-Hawkins, J.3
Von Bergmann, K.4
Lutjohann, D.5
Cohen, J.C.6
Hobbs, H.H.7
-
18
-
-
34547624651
-
Mouse models for atherosclerosis and pharmaceutical modifiers
-
Zadelaar S, Kleemann R, Verschuren L, de Vries-Van der Weij J, van der Hoorn J, Princen HM, Kooistra T 2007 Mouse models for atherosclerosis and pharmaceutical modifiers. Arterioscler Thromb Vasc Biol 27:1706-1721
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, pp. 1706-1721
-
-
Zadelaar, S.1
Kleemann, R.2
Verschuren, L.3
De Vries-Van Der Weij, J.4
Van Der Hoorn, J.5
Princen, H.M.6
Kooistra, T.7
-
19
-
-
0024236113
-
Apolipo-protein gene expression in the rat is regulated in a tissue-specific manner by thyroid hormone
-
Davidson NO, Carlos RC, Drewek MJ, Parmer TG 1988 Apolipo-protein gene expression in the rat is regulated in a tissue-specific manner by thyroid hormone. J Lipid Res 29:1511-1522
-
(1988)
J Lipid Res
, vol.29
, pp. 1511-1522
-
-
Davidson, N.O.1
Carlos, R.C.2
Drewek, M.J.3
Parmer, T.G.4
-
20
-
-
0026666655
-
Thyroid hormone modulates apolipoprotein B gene expression in HepG2 cells
-
Theriault A, Ogbonna G, Adeli K 1992 Thyroid hormone modulates apolipoprotein B gene expression in HepG2 cells. Biochem Biophys Res Commun 186:617-623
-
(1992)
Biochem Biophys Res Commun
, vol.186
, pp. 617-623
-
-
Theriault, A.1
Ogbonna, G.2
Adeli, K.3
-
21
-
-
0035968176
-
Increased production of apolipoprotein B-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol 7α-hydroxylase
-
Miyake JH, Doung XD, Strauss W, Moore GL, Castellani LW, Curtiss LK, Taylor JM, Davis RA 2001 Increased production of apolipoprotein B-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol 7α-hydroxylase. J Biol Chem 276:23304-23311
-
(2001)
J Biol Chem
, vol.276
, pp. 23304-23311
-
-
Miyake, J.H.1
Doung, X.D.2
Strauss, W.3
Moore, G.L.4
Castellani, L.W.5
Curtiss, L.K.6
Taylor, J.M.7
Davis, R.A.8
-
23
-
-
16044372347
-
Increasing hepatic cholesterol 7α-hydroxylase reduces plasma cholesterol concentrations in normocholesterolemic and hypercholesterolemic rabbits
-
Xu G, Salen G, Shefer S, Ness GC, Nguyen LB, Tint GS, Parker TS, Roberts J, Batta AK, Chen TS, Zhao Z, Kong X 1996 Increasing hepatic cholesterol 7α-hydroxylase reduces plasma cholesterol concentrations in normocholesterolemic and hypercholesterolemic rabbits. Hepatology 24:882-887
-
(1996)
Hepatology
, vol.24
, pp. 882-887
-
-
Xu, G.1
Salen, G.2
Shefer, S.3
Ness, G.C.4
Nguyen, L.B.5
Tint, G.S.6
Parker, T.S.7
Roberts, J.8
Batta, A.K.9
Chen, T.S.10
Zhao, Z.11
Kong, X.12
-
24
-
-
33746047162
-
Transgenic expression of CYP7A1 in LDL receptor-deficient mice blocks diet-induced hypercholesterolemia
-
Ratliff EP, Gutierrez A, Davis RA 2006 Transgenic expression of CYP7A1 in LDL receptor-deficient mice blocks diet-induced hypercholesterolemia. J Lipid Res 47:1513-1520
-
(2006)
J Lipid Res
, vol.47
, pp. 1513-1520
-
-
Ratliff, E.P.1
Gutierrez, A.2
Davis, R.A.3
-
25
-
-
0031594714
-
Overexpression of cholesterol 7α-hydroxylase (CYP7A) in mice lacking the low density lipoprotein (LDL) receptor gene
-
Spady DK, Cuthbert JA, Willard MN, Meidell RS 1998 Overexpression of cholesterol 7α-hydroxylase (CYP7A) in mice lacking the low density lipoprotein (LDL) receptor gene. J Biol Chem 273:126-132
-
(1998)
J Biol Chem
, vol.273
, pp. 126-132
-
-
Spady, D.K.1
Cuthbert, J.A.2
Willard, M.N.3
Meidell, R.S.4
-
26
-
-
0029160030
-
Adenovirusmediated transfer of a gene encoding cholesterol 7α-hydroxylase into hamsters increases hepatic enzyme activity and reduces plasma total and low density lipoprotein cholesterol
-
Spady DK, Cuthbert JA, Willard MN, Meidell RS 1995 Adenovirusmediated transfer of a gene encoding cholesterol 7α-hydroxylase into hamsters increases hepatic enzyme activity and reduces plasma total and low density lipoprotein cholesterol. J Clin Invest 96:700-709
-
(1995)
J Clin Invest
, vol.96
, pp. 700-709
-
-
Spady, D.K.1
Cuthbert, J.A.2
Willard, M.N.3
Meidell, R.S.4
-
27
-
-
0023094607
-
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels by L-triiodothyronine
-
Sample CE, Pendleton LC, Ness GC 1987 Regulation of 3-hydroxy-3- methylglutaryl coenzyme A reductase mRNA levels by L-triiodothyronine. Biochemistry 26:727-731
-
(1987)
Biochemistry
, vol.26
, pp. 727-731
-
-
Sample, C.E.1
Pendleton, L.C.2
Ness, G.C.3
-
28
-
-
1842580406
-
Cholesterol 7α-hydroxylase deficiency in mice on an APOE*3-Leiden background impairs very-low-density lipoprotein production
-
Post SM, Groenendijk M, Solaas K, Rensen PC, Princen HM 2004 Cholesterol 7α-hydroxylase deficiency in mice on an APOE*3-Leiden background impairs very-low-density lipoprotein production. Arterioscler Thromb Vasc Biol 24:768-774
-
(2004)
Arterioscler Thromb Vasc Biol
, vol.24
, pp. 768-774
-
-
Post, S.M.1
Groenendijk, M.2
Solaas, K.3
Rensen, P.C.4
Princen, H.M.5
-
29
-
-
33748519257
-
Two uniquely arranged thyroid hormone response elements in the far upstream 5′ flanking region confer direct thyroid hormone regulation to the murine cholesterol 7α hydroxylase gene
-
Shin DJ, Plateroti M, Samarut J, Osborne TF 2006 Two uniquely arranged thyroid hormone response elements in the far upstream 5′ flanking region confer direct thyroid hormone regulation to the murine cholesterol 7α hydroxylase gene. Nucleic Acids Res 34:3853-3861
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 3853-3861
-
-
Shin, D.J.1
Plateroti, M.2
Samarut, J.3
Osborne, T.F.4
-
30
-
-
0028865447
-
Transcriptional regulation of rat hepatic low-density lipoprotein receptor and cholesterol 7α hydroxylase by thyroid hormone
-
Ness GC, Lopez D 1995 Transcriptional regulation of rat hepatic low-density lipoprotein receptor and cholesterol 7α hydroxylase by thyroid hormone. Arch Biochem Biophys 323:404-408
-
(1995)
Arch Biochem Biophys
, vol.323
, pp. 404-408
-
-
Ness, G.C.1
Lopez, D.2
-
31
-
-
85047684249
-
Human cholesterol 7α-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype
-
Pullinger CR, Eng C, Salen G, Shefer S, Batta AK, Erickson SK, Verhagen A, Rivera CR, Mulvihill SJ, Malloy MJ, Kane JP 2002 Human cholesterol 7α-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype. J Clin Invest 110:109-117
-
(2002)
J Clin Invest
, vol.110
, pp. 109-117
-
-
Pullinger, C.R.1
Eng, C.2
Salen, G.3
Shefer, S.4
Batta, A.K.5
Erickson, S.K.6
Verhagen, A.7
Rivera, C.R.8
Mulvihill, S.J.9
Malloy, M.J.10
Kane, J.P.11
-
32
-
-
0842269844
-
Regulation of the human cholesterol 7α-hydroxylase gene (CYP7A1) by thyroid hormone in transgenic mice
-
Drover VA, Agellon LB 2004 Regulation of the human cholesterol 7α-hydroxylase gene (CYP7A1) by thyroid hormone in transgenic mice. Endocrinology 145:574-581
-
(2004)
Endocrinology
, vol.145
, pp. 574-581
-
-
Drover, V.A.1
Agellon, L.B.2
-
33
-
-
38649135692
-
The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans
-
Berkenstam A, Kristensen J, Mellström K, Carlsson B, Malm J, Rehnmark S, Garg N, Andersson CM, Rudling M, Sjöberg F, Angelin B, Baxter JD 2008 The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans. Proc Natl Acad Sci USA 105:663-667
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 663-667
-
-
Berkenstam, A.1
Kristensen, J.2
Mellström, K.3
Carlsson, B.4
Malm, J.5
Rehnmark, S.6
Garg, N.7
Andersson, C.M.8
Rudling, M.9
Sjöberg, F.10
Angelin, B.11
Baxter, J.D.12
-
34
-
-
77949349469
-
Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia
-
Ladenson PW, Kristensen JD, Ridgway EC, Olsson AG, Carlsson B, Klein I, Baxter JD, Angelin B 2010 Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia. N Engl J Med 362:906-916
-
(2010)
N Engl J Med
, vol.362
, pp. 906-916
-
-
Ladenson, P.W.1
Kristensen, J.D.2
Ridgway, E.C.3
Olsson, A.G.4
Carlsson, B.5
Klein, I.6
Baxter, J.D.7
Angelin, B.8
|