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Volumn 34, Issue 7, 2013, Pages 373-384

Assessment of endothelial and neurovascular function in human skin microcirculation

Author keywords

endothelium; iontophoresis; laser Doppler; laser speckle; local thermal hyperemia; microcirculation; microdialysis; post occlusive hyperemia; skin

Indexed keywords

ACETYLCHOLINE; NITROPRUSSIDE SODIUM;

EID: 84879780847     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2013.05.007     Document Type: Review
Times cited : (282)

References (104)
  • 2
    • 67649390994 scopus 로고    scopus 로고
    • Therapeutic potential of pharmacologically targeting arteriolar myogenic tone
    • M.A. Hill Therapeutic potential of pharmacologically targeting arteriolar myogenic tone Trends Pharmacol. Sci. 30 2009 363 374
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 363-374
    • Hill, M.A.1
  • 3
    • 84865639708 scopus 로고    scopus 로고
    • Oxidant stress and skeletal muscle microvasculopathy in the metabolic syndrome
    • A.G. Goodwill, and J.C. Frisbee Oxidant stress and skeletal muscle microvasculopathy in the metabolic syndrome Vasc. Pharmacol. 57 2012 150 159
    • (2012) Vasc. Pharmacol. , vol.57 , pp. 150-159
    • Goodwill, A.G.1    Frisbee, J.C.2
  • 4
    • 79951513390 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide (CGRP) and its role in hypertension
    • S.J. Smillie, and S.D. Brain Calcitonin gene-related peptide (CGRP) and its role in hypertension Neuropeptides 45 2011 93 104
    • (2011) Neuropeptides , vol.45 , pp. 93-104
    • Smillie, S.J.1    Brain, S.D.2
  • 5
    • 57349113995 scopus 로고    scopus 로고
    • Nitric oxide inhibits cutaneous vasoconstriction to exogenous norepinephrine
    • M. Shibasaki Nitric oxide inhibits cutaneous vasoconstriction to exogenous norepinephrine J. Appl. Physiol. 105 2008 1504 1508
    • (2008) J. Appl. Physiol. , vol.105 , pp. 1504-1508
    • Shibasaki, M.1
  • 6
    • 79956200976 scopus 로고    scopus 로고
    • Modulation of cytochrome-derived epoxyeicosatrienoic acids pathway: A promising pharmacological approach to prevent endothelial dysfunction in cardiovascular diseases?
    • J. Bellien Modulation of cytochrome-derived epoxyeicosatrienoic acids pathway: a promising pharmacological approach to prevent endothelial dysfunction in cardiovascular diseases? Pharmacol. Ther. 131 2011 1 17
    • (2011) Pharmacol. Ther. , vol.131 , pp. 1-17
    • Bellien, J.1
  • 7
    • 52049100625 scopus 로고    scopus 로고
    • Impaired tissue perfusion: A pathology common to hypertension, obesity, and diabetes mellitus
    • B.I. Levy Impaired tissue perfusion: a pathology common to hypertension, obesity, and diabetes mellitus Circulation 118 2008 968 976
    • (2008) Circulation , vol.118 , pp. 968-976
    • Levy, B.I.1
  • 8
    • 33751076238 scopus 로고    scopus 로고
    • Hypertension: A disease of the microcirculation?
    • F. Feihl Hypertension: a disease of the microcirculation? Hypertension 48 2006 1012 1017
    • (2006) Hypertension , vol.48 , pp. 1012-1017
    • Feihl, F.1
  • 9
    • 0035127180 scopus 로고    scopus 로고
    • Correlation of endothelial function in large and small arteries in human essential hypertension
    • J.B. Park Correlation of endothelial function in large and small arteries in human essential hypertension J. Hypertens. 19 2001 415 420
    • (2001) J. Hypertens. , vol.19 , pp. 415-420
    • Park, J.B.1
  • 10
    • 27944465342 scopus 로고    scopus 로고
    • Oxidative stress contributes to the enhanced expression of Gialpha proteins and adenylyl cyclase signaling in vascular smooth muscle cells from spontaneously hypertensive rats
    • G. Lappas Oxidative stress contributes to the enhanced expression of Gialpha proteins and adenylyl cyclase signaling in vascular smooth muscle cells from spontaneously hypertensive rats J. Hypertens. 23 2005 2251 2261
    • (2005) J. Hypertens. , vol.23 , pp. 2251-2261
    • Lappas, G.1
  • 11
    • 26244454791 scopus 로고    scopus 로고
    • Oxidative stress promotes endothelial cell apoptosis and loss of microvessels in the spontaneously hypertensive rats
    • N. Kobayashi Oxidative stress promotes endothelial cell apoptosis and loss of microvessels in the spontaneously hypertensive rats Arterioscler. Thromb. Vasc. Biol. 25 2005 2114 2121
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25 , pp. 2114-2121
    • Kobayashi, N.1
  • 12
    • 77954213023 scopus 로고    scopus 로고
    • Alteration of nitric oxide-mediated blood flow regulation in diabetes mellitus
    • N. Toda Alteration of nitric oxide-mediated blood flow regulation in diabetes mellitus Pharmacol. Ther. 127 2010 189 209
    • (2010) Pharmacol. Ther. , vol.127 , pp. 189-209
    • Toda, N.1
  • 13
    • 80051983016 scopus 로고    scopus 로고
    • Diabetic retinopathy is related to both endothelium-dependent and -independent responses of skin microvascular flow
    • T.T. Nguyen Diabetic retinopathy is related to both endothelium-dependent and -independent responses of skin microvascular flow Diabetes Care 34 2011 1389 1393
    • (2011) Diabetes Care , vol.34 , pp. 1389-1393
    • Nguyen, T.T.1
  • 15
    • 84870059676 scopus 로고    scopus 로고
    • Microvascular dysfunction is associated with a higher incidence of type 2 diabetes mellitus: A systematic review and meta-analysis
    • D.M. Muris Microvascular dysfunction is associated with a higher incidence of type 2 diabetes mellitus: a systematic review and meta-analysis Arterioscler. Thromb. Vasc. Biol. 32 2012 3082 3094
    • (2012) Arterioscler. Thromb. Vasc. Biol. , vol.32 , pp. 3082-3094
    • Muris, D.M.1
  • 16
    • 80052269271 scopus 로고    scopus 로고
    • Does microvascular disease predict macrovascular events in type 2 diabetes?
    • R.S. Rosenson Does microvascular disease predict macrovascular events in type 2 diabetes? Atherosclerosis 218 2011 13 18
    • (2011) Atherosclerosis , vol.218 , pp. 13-18
    • Rosenson, R.S.1
  • 17
    • 0031227935 scopus 로고    scopus 로고
    • The cutaneous microcirculation: Ultrastructure and microanatomical organization
    • I.M. Braverman The cutaneous microcirculation: ultrastructure and microanatomical organization Microcirculation 4 1997 329 340
    • (1997) Microcirculation , vol.4 , pp. 329-340
    • Braverman, I.M.1
  • 18
    • 50649092934 scopus 로고    scopus 로고
    • The human cutaneous circulation as a model of generalized microvascular function
    • L.A. Holowatz The human cutaneous circulation as a model of generalized microvascular function J. Appl. Physiol. 105 2008 370 372
    • (2008) J. Appl. Physiol. , vol.105 , pp. 370-372
    • Holowatz, L.A.1
  • 19
    • 0037789568 scopus 로고    scopus 로고
    • Individuals at increased coronary heart disease risk are characterized by an impaired microvascular function in skin
    • R.G. IJzerman Individuals at increased coronary heart disease risk are characterized by an impaired microvascular function in skin Eur. J. Clin. Invest. 33 2003 536 542
    • (2003) Eur. J. Clin. Invest. , vol.33 , pp. 536-542
    • Ijzerman, R.G.1
  • 20
    • 58149235097 scopus 로고    scopus 로고
    • Relationship between post-occlusive forearm skin reactive hyperaemia and vascular disease in patients with type 2 diabetes - A novel index for detecting micro- and macrovascular dysfunction using laser Doppler flowmetry
    • R. Yamamoto-Suganuma, and Y. Aso Relationship between post-occlusive forearm skin reactive hyperaemia and vascular disease in patients with type 2 diabetes - a novel index for detecting micro- and macrovascular dysfunction using laser Doppler flowmetry Diabet. Med. 26 2009 83 88
    • (2009) Diabet. Med. , vol.26 , pp. 83-88
    • Yamamoto-Suganuma, R.1    Aso, Y.2
  • 21
    • 33745697873 scopus 로고    scopus 로고
    • Laser Doppler flowmetry detection of endothelial dysfunction in end-stage renal disease patients: Correlation with cardiovascular risk
    • A. Kruger Laser Doppler flowmetry detection of endothelial dysfunction in end-stage renal disease patients: correlation with cardiovascular risk Kidney Int. 70 2006 157 164
    • (2006) Kidney Int. , vol.70 , pp. 157-164
    • Kruger, A.1
  • 22
    • 0033596638 scopus 로고    scopus 로고
    • Microvascular function relates to insulin sensitivity and blood pressure in normal subjects
    • E.H. Serne Microvascular function relates to insulin sensitivity and blood pressure in normal subjects Circulation 99 1999 896 902
    • (1999) Circulation , vol.99 , pp. 896-902
    • Serne, E.H.1
  • 23
    • 84155184307 scopus 로고    scopus 로고
    • Non-invasive assessment of skin microvascular function in humans: An insight into methods
    • M. Roustit, and J.L. Cracowski Non-invasive assessment of skin microvascular function in humans: an insight into methods Microcirculation 19 2012 47 64
    • (2012) Microcirculation , vol.19 , pp. 47-64
    • Roustit, M.1    Cracowski, J.L.2
  • 24
    • 84874934644 scopus 로고    scopus 로고
    • Microcirculatory alterations in patients with severe sepsis: Impact of time of assessment and relationship with outcome
    • D. De Backer Microcirculatory alterations in patients with severe sepsis: impact of time of assessment and relationship with outcome Crit. Care Med. 41 2013 791 799
    • (2013) Crit. Care Med. , vol.41 , pp. 791-799
    • De Backer, D.1
  • 26
    • 78650414203 scopus 로고    scopus 로고
    • Monitoring the microcirculation in the critically ill patient: Current methods and future approaches
    • D. De Backer Monitoring the microcirculation in the critically ill patient: current methods and future approaches Intensive Care Med. 36 2010 1813 1825
    • (2010) Intensive Care Med. , vol.36 , pp. 1813-1825
    • De Backer, D.1
  • 27
    • 0016630468 scopus 로고
    • In vivo evaluation of microcirculation by coherent light scattering
    • M.D. Stern In vivo evaluation of microcirculation by coherent light scattering Nature 254 1975 56 58
    • (1975) Nature , vol.254 , pp. 56-58
    • Stern, M.D.1
  • 28
    • 0023306277 scopus 로고
    • In vivo evaluation of signal processors for laser Doppler tissue flowmeters
    • H. Ahn In vivo evaluation of signal processors for laser Doppler tissue flowmeters Med. Biol. Eng. Comput. 25 1987 207 211
    • (1987) Med. Biol. Eng. Comput. , vol.25 , pp. 207-211
    • Ahn, H.1
  • 29
    • 76749153285 scopus 로고    scopus 로고
    • Reproducibility and methodological issues of skin post-occlusive and thermal hyperemia assessed by single-point laser Doppler flowmetry
    • M. Roustit Reproducibility and methodological issues of skin post-occlusive and thermal hyperemia assessed by single-point laser Doppler flowmetry Microvasc. Res. 79 2010 102 108
    • (2010) Microvasc. Res. , vol.79 , pp. 102-108
    • Roustit, M.1
  • 30
    • 75449109880 scopus 로고    scopus 로고
    • Comparative reproducibility of dermal microvascular blood flow changes in response to acetylcholine iontophoresis, hyperthermia and reactive hyperaemia
    • S.C. Agarwal Comparative reproducibility of dermal microvascular blood flow changes in response to acetylcholine iontophoresis, hyperthermia and reactive hyperaemia Physiol. Meas. 31 2010 1 11
    • (2010) Physiol. Meas. , vol.31 , pp. 1-11
    • Agarwal, S.C.1
  • 31
    • 79651471671 scopus 로고    scopus 로고
    • Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults
    • G.A. Tew Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults Microvasc. Res. 81 2011 177 182
    • (2011) Microvasc. Res. , vol.81 , pp. 177-182
    • Tew, G.A.1
  • 32
    • 78249231988 scopus 로고    scopus 로고
    • Excellent reproducibility of laser speckle contrast imaging to assess skin microvascular reactivity
    • M. Roustit Excellent reproducibility of laser speckle contrast imaging to assess skin microvascular reactivity Microvasc. Res. 80 2010 505 511
    • (2010) Microvasc. Res. , vol.80 , pp. 505-511
    • Roustit, M.1
  • 33
    • 0035181228 scopus 로고    scopus 로고
    • Laser Doppler, speckle and related techniques for blood perfusion mapping and imaging
    • J.D. Briers Laser Doppler, speckle and related techniques for blood perfusion mapping and imaging Physiol. Meas. 22 2001 R35 R66
    • (2001) Physiol. Meas. , vol.22
    • Briers, J.D.1
  • 34
    • 77956642070 scopus 로고    scopus 로고
    • Tissue perfusion measurements: Multiple-exposure laser speckle analysis generates laser Doppler-like spectra
    • O.B. Thompson, and M.K. Andrews Tissue perfusion measurements: multiple-exposure laser speckle analysis generates laser Doppler-like spectra J. Biomed. Opt. 15 2010 027015
    • (2010) J. Biomed. Opt. , vol.15 , pp. 027015
    • Thompson, O.B.1    Andrews, M.K.2
  • 35
    • 70349246564 scopus 로고    scopus 로고
    • Comparison of instruments for investigation of microcirculatory blood flow and red blood cell concentration
    • J. O'Doherty Comparison of instruments for investigation of microcirculatory blood flow and red blood cell concentration J. Biomed. Opt. 14 2009 034025
    • (2009) J. Biomed. Opt. , vol.14 , pp. 034025
    • O'Doherty, J.1
  • 36
    • 79960926469 scopus 로고    scopus 로고
    • Comparison between laser speckle contrast imaging and laser Doppler imaging to assess skin blood flow in humans
    • C. Millet Comparison between laser speckle contrast imaging and laser Doppler imaging to assess skin blood flow in humans Microvasc. Res. 82 2011 147 151
    • (2011) Microvasc. Res. , vol.82 , pp. 147-151
    • Millet, C.1
  • 37
    • 81055157019 scopus 로고    scopus 로고
    • Comparison of laser speckle contrast imaging with laser Doppler for assessing microvascular function
    • G.A. Tew Comparison of laser speckle contrast imaging with laser Doppler for assessing microvascular function Microvasc. Res. 82 2011 326 332
    • (2011) Microvasc. Res. , vol.82 , pp. 326-332
    • Tew, G.A.1
  • 38
    • 0037116573 scopus 로고    scopus 로고
    • Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force
    • M.C. Corretti Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force J. Am. Coll. Cardiol. 39 2002 257 265
    • (2002) J. Am. Coll. Cardiol. , vol.39 , pp. 257-265
    • Corretti, M.C.1
  • 39
    • 33747191461 scopus 로고    scopus 로고
    • Methodological issues in the assessment of skin microvascular endothelial function in humans
    • J.L. Cracowski Methodological issues in the assessment of skin microvascular endothelial function in humans Trends Pharmacol. Sci. 27 2006 503 508
    • (2006) Trends Pharmacol. Sci. , vol.27 , pp. 503-508
    • Cracowski, J.L.1
  • 40
    • 34547111797 scopus 로고    scopus 로고
    • Cyclooxygenase and nitric oxide synthase dependence of cutaneous reactive hyperemia in humans
    • M.S. Medow Cyclooxygenase and nitric oxide synthase dependence of cutaneous reactive hyperemia in humans Am. J. Physiol. Heart Circ. Physiol. 293 2007 H425 H432
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.293
    • Medow, M.S.1
  • 41
    • 0027254447 scopus 로고
    • Evidence for sensory nerve involvement in cutaneous reactive hyperemia in humans
    • S.W. Larkin, and T.J. Williams Evidence for sensory nerve involvement in cutaneous reactive hyperemia in humans Circ. Res. 73 1993 147 154
    • (1993) Circ. Res. , vol.73 , pp. 147-154
    • Larkin, S.W.1    Williams, T.J.2
  • 43
    • 33847165261 scopus 로고    scopus 로고
    • Effects of local anaesthesia on subdermal needle insertion pain and subsequent tests of microvascular function in human
    • J.L. Cracowski Effects of local anaesthesia on subdermal needle insertion pain and subsequent tests of microvascular function in human Eur. J. Pharmacol. 559 2007 150 154
    • (2007) Eur. J. Pharmacol. , vol.559 , pp. 150-154
    • Cracowski, J.L.1
  • 44
    • 84872319882 scopus 로고    scopus 로고
    • Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans
    • J.L. Cracowski Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans J. Appl. Physiol. 114 2013 245 251
    • (2013) J. Appl. Physiol. , vol.114 , pp. 245-251
    • Cracowski, J.L.1
  • 45
    • 0043130724 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibition does not alter the reactive hyperemic response in the cutaneous circulation
    • B.J. Wong Nitric oxide synthase inhibition does not alter the reactive hyperemic response in the cutaneous circulation J. Appl. Physiol. 95 2003 504 510
    • (2003) J. Appl. Physiol. , vol.95 , pp. 504-510
    • Wong, B.J.1
  • 46
    • 0942287707 scopus 로고    scopus 로고
    • Bioactive nitric oxide concentration does not increase during reactive hyperemia in human skin
    • J.L. Zhao Bioactive nitric oxide concentration does not increase during reactive hyperemia in human skin J. Appl. Physiol. 96 2004 628 632
    • (2004) J. Appl. Physiol. , vol.96 , pp. 628-632
    • Zhao, J.L.1
  • 47
    • 84873405026 scopus 로고    scopus 로고
    • No implication of thromboxane-prostanoid receptors in reactive hyperemia of skin and skeletal muscle in human forearm
    • A. Pasche No implication of thromboxane-prostanoid receptors in reactive hyperemia of skin and skeletal muscle in human forearm J. Cardiovasc. Pharmacol. 61 2013 127 132
    • (2013) J. Cardiovasc. Pharmacol. , vol.61 , pp. 127-132
    • Pasche, A.1
  • 48
    • 0038643521 scopus 로고    scopus 로고
    • Statins enhance postischemic hyperemia in the skin circulation of hypercholesterolemic patients: A monitoring test of endothelial dysfunction for clinical practice?
    • C. Binggeli Statins enhance postischemic hyperemia in the skin circulation of hypercholesterolemic patients: a monitoring test of endothelial dysfunction for clinical practice? J. Am. Coll. Cardiol. 42 2003 71 77
    • (2003) J. Am. Coll. Cardiol. , vol.42 , pp. 71-77
    • Binggeli, C.1
  • 49
    • 77951297913 scopus 로고    scopus 로고
    • Associations between cardiac target organ damage and microvascular dysfunction: The role of blood pressure
    • W.D. Strain Associations between cardiac target organ damage and microvascular dysfunction: the role of blood pressure J. Hypertens. 28 2010 952 958
    • (2010) J. Hypertens. , vol.28 , pp. 952-958
    • Strain, W.D.1
  • 50
    • 84879783805 scopus 로고    scopus 로고
    • Peripheral microvascular dysfunction as an independent predictor of atherosclerotic damage in type 1 diabetes patients: A preliminary study
    • 10.3233/CH-2012-1628
    • M. Rossi Peripheral microvascular dysfunction as an independent predictor of atherosclerotic damage in type 1 diabetes patients: a preliminary study Clin. Hemorheol. Microcirc. 2013 10.3233/CH-2012-1628
    • (2013) Clin. Hemorheol. Microcirc.
    • Rossi, M.1
  • 51
    • 79960618211 scopus 로고    scopus 로고
    • Investigation of skin vasoreactivity and blood flow oscillations in hypertensive patients: Effect of short-term antihypertensive treatment
    • M. Rossi Investigation of skin vasoreactivity and blood flow oscillations in hypertensive patients: effect of short-term antihypertensive treatment J. Hypertens. 29 2011 1569 1576
    • (2011) J. Hypertens. , vol.29 , pp. 1569-1576
    • Rossi, M.1
  • 52
    • 84864671626 scopus 로고    scopus 로고
    • Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers
    • B. Fromy Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers Nat. Med. 18 2012 1205 1207
    • (2012) Nat. Med. , vol.18 , pp. 1205-1207
    • Fromy, B.1
  • 53
    • 76649102085 scopus 로고    scopus 로고
    • Aging-associated sensory neuropathy alters pressure-induced vasodilation in humans
    • B. Fromy Aging-associated sensory neuropathy alters pressure-induced vasodilation in humans J. Invest. Dermatol. 130 2010 849 855
    • (2010) J. Invest. Dermatol. , vol.130 , pp. 849-855
    • Fromy, B.1
  • 54
    • 1442301076 scopus 로고    scopus 로고
    • Impaired pressure-induced vasodilation at the foot in young adults with type 1 diabetes
    • A. Koitka Impaired pressure-induced vasodilation at the foot in young adults with type 1 diabetes Diabetes 53 2004 721 725
    • (2004) Diabetes , vol.53 , pp. 721-725
    • Koitka, A.1
  • 55
    • 0036224333 scopus 로고    scopus 로고
    • Early decrease of skin blood flow in response to locally applied pressure in diabetic subjects
    • B. Fromy Early decrease of skin blood flow in response to locally applied pressure in diabetic subjects Diabetes 51 2002 1214 1217
    • (2002) Diabetes , vol.51 , pp. 1214-1217
    • Fromy, B.1
  • 56
    • 78149317291 scopus 로고    scopus 로고
    • Thermal provocation to evaluate microvascular reactivity in human skin
    • C.T. Minson Thermal provocation to evaluate microvascular reactivity in human skin J. Appl. Physiol. 109 2010 1239 1246
    • (2010) J. Appl. Physiol. , vol.109 , pp. 1239-1246
    • Minson, C.T.1
  • 57
    • 79960209058 scopus 로고    scopus 로고
    • Cutaneous thermal hyperemia: More than skin deep
    • V.E. Brunt, and C.T. Minson Cutaneous thermal hyperemia: more than skin deep J. Appl. Physiol. 111 2011 5 7
    • (2011) J. Appl. Physiol. , vol.111 , pp. 5-7
    • Brunt, V.E.1    Minson, C.T.2
  • 58
    • 78049486892 scopus 로고    scopus 로고
    • Transient receptor potential vanilloid type-1 (TRPV-1) channels contribute to cutaneous thermal hyperaemia in humans
    • B.J. Wong, and S.M. Fieger Transient receptor potential vanilloid type-1 (TRPV-1) channels contribute to cutaneous thermal hyperaemia in humans J. Physiol. 588 2010 4317 4326
    • (2010) J. Physiol. , vol.588 , pp. 4317-4326
    • Wong, B.J.1    Fieger, S.M.2
  • 59
    • 79960209059 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS) from NADPH and xanthine oxidase modulate the cutaneous local heating response in healthy humans
    • M.S. Medow Reactive oxygen species (ROS) from NADPH and xanthine oxidase modulate the cutaneous local heating response in healthy humans J. Appl. Physiol. 111 2011 20 26
    • (2011) J. Appl. Physiol. , vol.111 , pp. 20-26
    • Medow, M.S.1
  • 60
    • 33748442883 scopus 로고    scopus 로고
    • Prostanoids contribute to cutaneous active vasodilation in humans
    • G.R. McCord Prostanoids contribute to cutaneous active vasodilation in humans Am. J. Physiol. Regul. Integr. Comp. Physiol. 291 2006 R596 R602
    • (2006) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.291
    • McCord, G.R.1
  • 61
    • 84864292543 scopus 로고    scopus 로고
    • Ca channels and epoxyeicosatrienoic acids: Major contributors to thermal hyperaemia in human skin
    • Ca channels and epoxyeicosatrienoic acids: major contributors to thermal hyperaemia in human skin J. Physiol. 590 2012 3523 3534
    • (2012) J. Physiol. , vol.590 , pp. 3523-3534
    • Brunt, V.E.1    Minson, C.T.2
  • 62
    • 78149354453 scopus 로고    scopus 로고
    • Local thermal control of the human cutaneous circulation
    • J.M. Johnson, and D.L. Kellogg Jr Local thermal control of the human cutaneous circulation J. Appl. Physiol. 109 2010 1229 1238
    • (2010) J. Appl. Physiol. , vol.109 , pp. 1229-1238
    • Johnson, J.M.1    Kellogg, Jr.D.L.2
  • 63
    • 85027923032 scopus 로고    scopus 로고
    • Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans
    • C.J. Smith Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans Hypertension 58 2011 935 942
    • (2011) Hypertension , vol.58 , pp. 935-942
    • Smith, C.J.1
  • 64
    • 84875059486 scopus 로고    scopus 로고
    • Nitric oxide-mediated cutaneous microvascular function is impaired in polycystic ovary syndrome but can be improved by exercise training
    • V.S. Sprung Nitric oxide-mediated cutaneous microvascular function is impaired in polycystic ovary syndrome but can be improved by exercise training J. Physiol. 591 2013 1475 1487
    • (2013) J. Physiol. , vol.591 , pp. 1475-1487
    • Sprung, V.S.1
  • 65
    • 79954564392 scopus 로고    scopus 로고
    • Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans
    • L.A. Holowatz Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans J. Physiol. 589 2011 2093 2103
    • (2011) J. Physiol. , vol.589 , pp. 2093-2103
    • Holowatz, L.A.1
  • 66
    • 73449137173 scopus 로고    scopus 로고
    • Reproducibility of a local cooling test to assess microvascular function in human skin
    • M. Roustit Reproducibility of a local cooling test to assess microvascular function in human skin Microvasc. Res. 79 2010 34 39
    • (2010) Microvasc. Res. , vol.79 , pp. 34-39
    • Roustit, M.1
  • 67
    • 34147115492 scopus 로고    scopus 로고
    • Cold-induced cutaneous vasoconstriction is mediated by Rho kinase in vivo in human skin
    • C.S. Thompson-Torgerson Cold-induced cutaneous vasoconstriction is mediated by Rho kinase in vivo in human skin Am. J. Physiol. Heart Circ. Physiol. 292 2007 H1700 H1705
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.292
    • Thompson-Torgerson, C.S.1
  • 68
    • 79961094539 scopus 로고    scopus 로고
    • Impaired transient vasodilation and increased vasoconstriction to digital local cooling in primary Raynaud's phenomenon
    • M. Roustit Impaired transient vasodilation and increased vasoconstriction to digital local cooling in primary Raynaud's phenomenon Am. J. Physiol. Heart Circ. Physiol. 301 2011 H324 H330
    • (2011) Am. J. Physiol. Heart Circ. Physiol. , vol.301
    • Roustit, M.1
  • 69
    • 84859948539 scopus 로고    scopus 로고
    • Sildenafil increases digital skin blood flow during all phases of local cooling in primary Raynaud's phenomenon
    • M. Roustit Sildenafil increases digital skin blood flow during all phases of local cooling in primary Raynaud's phenomenon Clin. Pharmacol. Ther. 91 2012 813 819
    • (2012) Clin. Pharmacol. Ther. , vol.91 , pp. 813-819
    • Roustit, M.1
  • 70
    • 84863202226 scopus 로고    scopus 로고
    • Efficacy of Rho kinase inhibitor fasudil in secondary Raynaud's phenomenon
    • A. Fava Efficacy of Rho kinase inhibitor fasudil in secondary Raynaud's phenomenon Arthritis Care Res. (Hoboken) 64 2012 925 929
    • (2012) Arthritis Care Res. (Hoboken) , vol.64 , pp. 925-929
    • Fava, A.1
  • 71
    • 84862531517 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin
    • R.S. Bruning Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin J. Appl. Physiol. 112 2012 2019 2026
    • (2012) J. Appl. Physiol. , vol.112 , pp. 2019-2026
    • Bruning, R.S.1
  • 72
    • 15844425840 scopus 로고    scopus 로고
    • Mechanisms of acetylcholine-mediated vasodilatation in young and aged human skin
    • L.A. Holowatz Mechanisms of acetylcholine-mediated vasodilatation in young and aged human skin J. Physiol. 563 2005 965 973
    • (2005) J. Physiol. , vol.563 , pp. 965-973
    • Holowatz, L.A.1
  • 73
    • 77953226483 scopus 로고    scopus 로고
    • Oral sildenafil increases skin hyperaemia induced by iontophoresis of sodium nitroprusside in healthy volunteers
    • S. Blaise Oral sildenafil increases skin hyperaemia induced by iontophoresis of sodium nitroprusside in healthy volunteers Br. J. Pharmacol. 160 2010 1128 1134
    • (2010) Br. J. Pharmacol. , vol.160 , pp. 1128-1134
    • Blaise, S.1
  • 74
    • 1542298892 scopus 로고    scopus 로고
    • Iontophoretic drug delivery
    • Y.N. Kalia Iontophoretic drug delivery Adv. Drug Deliv. Rev. 56 2004 619 658
    • (2004) Adv. Drug Deliv. Rev. , vol.56 , pp. 619-658
    • Kalia, Y.N.1
  • 75
    • 33747879300 scopus 로고    scopus 로고
    • Effects of metformin on microvascular function and exercise tolerance in women with angina and normal coronary arteries: A randomized, double-blind, placebo-controlled study
    • S. Jadhav Effects of metformin on microvascular function and exercise tolerance in women with angina and normal coronary arteries: a randomized, double-blind, placebo-controlled study J. Am. Coll. Cardiol. 48 2006 956 963
    • (2006) J. Am. Coll. Cardiol. , vol.48 , pp. 956-963
    • Jadhav, S.1
  • 76
    • 84865828984 scopus 로고    scopus 로고
    • Obstructive sleep apnea and diabetic neuropathy: A novel association in patients with type 2 diabetes
    • A.A. Tahrani Obstructive sleep apnea and diabetic neuropathy: a novel association in patients with type 2 diabetes Am. J. Respir. Crit. Care Med. 186 2012 434 441
    • (2012) Am. J. Respir. Crit. Care Med. , vol.186 , pp. 434-441
    • Tahrani, A.A.1
  • 77
    • 78650276701 scopus 로고    scopus 로고
    • What can current stimulation tell us about the vascular function of endogenous prostacyclin in healthy rat skin in vivo?
    • S. Gohin What can current stimulation tell us about the vascular function of endogenous prostacyclin in healthy rat skin in vivo? J. Invest. Dermatol. 131 2011 237 244
    • (2011) J. Invest. Dermatol. , vol.131 , pp. 237-244
    • Gohin, S.1
  • 78
    • 33646669021 scopus 로고    scopus 로고
    • Microdialysis of large molecules
    • G.F. Clough Microdialysis of large molecules AAPS J. 7 2005 E686 E692
    • (2005) AAPS J. , vol.7
    • Clough, G.F.1
  • 79
    • 0034807992 scopus 로고    scopus 로고
    • Nitric oxide and neurally mediated regulation of skin blood flow during local heating
    • C.T. Minson Nitric oxide and neurally mediated regulation of skin blood flow during local heating J. Appl. Physiol. 91 2001 1619 1626
    • (2001) J. Appl. Physiol. , vol.91 , pp. 1619-1626
    • Minson, C.T.1
  • 80
    • 81055156681 scopus 로고    scopus 로고
    • Skin microdialysis coupled with laser speckle contrast imaging to assess microvascular reactivity
    • J.L. Cracowski Skin microdialysis coupled with laser speckle contrast imaging to assess microvascular reactivity Microvasc. Res. 82 2011 333 338
    • (2011) Microvasc. Res. , vol.82 , pp. 333-338
    • Cracowski, J.L.1
  • 81
    • 79957859121 scopus 로고    scopus 로고
    • Increasing the 'region of interest' and 'time of interest' both reduce the variability of blood flow measurements using laser speckle contrast imaging
    • P. Rousseau Increasing the 'region of interest' and 'time of interest' both reduce the variability of blood flow measurements using laser speckle contrast imaging Microvasc. Res. 82 2011 88 91
    • (2011) Microvasc. Res. , vol.82 , pp. 88-91
    • Rousseau, P.1
  • 82
    • 34047253610 scopus 로고    scopus 로고
    • Noninvasive measure of microvascular nitric oxide function in humans using very low-frequency cutaneous laser Doppler flow spectra
    • J.M. Stewart Noninvasive measure of microvascular nitric oxide function in humans using very low-frequency cutaneous laser Doppler flow spectra Microcirculation 14 2007 169 180
    • (2007) Microcirculation , vol.14 , pp. 169-180
    • Stewart, J.M.1
  • 83
    • 33750619115 scopus 로고    scopus 로고
    • Low-frequency oscillations of the laser Doppler perfusion signal in human skin
    • P. Kvandal Low-frequency oscillations of the laser Doppler perfusion signal in human skin Microvasc. Res. 72 2006 120 127
    • (2006) Microvasc. Res. , vol.72 , pp. 120-127
    • Kvandal, P.1
  • 84
    • 55149116969 scopus 로고    scopus 로고
    • Skin vasomotion investigation: A useful tool for clinical evaluation of microvascular endothelial function?
    • M. Rossi Skin vasomotion investigation: a useful tool for clinical evaluation of microvascular endothelial function? Biomed. Pharmacother. 62 2008 541 545
    • (2008) Biomed. Pharmacother. , vol.62 , pp. 541-545
    • Rossi, M.1
  • 85
    • 66349110000 scopus 로고    scopus 로고
    • Vascular disease in scleroderma
    • F.M. Wigley Vascular disease in scleroderma Clin. Rev. Allergy Immunol. 36 2009 150 175
    • (2009) Clin. Rev. Allergy Immunol. , vol.36 , pp. 150-175
    • Wigley, F.M.1
  • 86
    • 84864625242 scopus 로고    scopus 로고
    • The pathogenesis, diagnosis and treatment of Raynaud phenomenon
    • A.L. Herrick The pathogenesis, diagnosis and treatment of Raynaud phenomenon Nat. Rev. Rheumatol. 8 2012 469 479
    • (2012) Nat. Rev. Rheumatol. , vol.8 , pp. 469-479
    • Herrick, A.L.1
  • 87
    • 62549122964 scopus 로고    scopus 로고
    • A growing need for capillaroscopy in rheumatology
    • R. De Angelis A growing need for capillaroscopy in rheumatology Arthritis Rheum. 61 2009 405 410
    • (2009) Arthritis Rheum. , vol.61 , pp. 405-410
    • De Angelis, R.1
  • 88
    • 37349013596 scopus 로고    scopus 로고
    • Improving the sensitivity of the American College of Rheumatology classification criteria for systemic sclerosis
    • M. Hudson Improving the sensitivity of the American College of Rheumatology classification criteria for systemic sclerosis Clin. Exp. Rheumatol. 25 2007 754 757
    • (2007) Clin. Exp. Rheumatol. , vol.25 , pp. 754-757
    • Hudson, M.1
  • 89
    • 47249092325 scopus 로고    scopus 로고
    • Prognostic model based on nailfold capillaroscopy for identifying Raynaud's phenomenon patients at high risk for the development of a scleroderma spectrum disorder: PRINCE (prognostic index for nailfold capillaroscopic examination)
    • F. Ingegnoli Prognostic model based on nailfold capillaroscopy for identifying Raynaud's phenomenon patients at high risk for the development of a scleroderma spectrum disorder: PRINCE (prognostic index for nailfold capillaroscopic examination) Arthritis Rheum. 58 2008 2174 2182
    • (2008) Arthritis Rheum. , vol.58 , pp. 2174-2182
    • Ingegnoli, F.1
  • 90
    • 77953212586 scopus 로고    scopus 로고
    • Peripheral blood perfusion correlates with microvascular abnormalities in systemic sclerosis: A laser-Doppler and nailfold videocapillaroscopy study
    • M. Cutolo Peripheral blood perfusion correlates with microvascular abnormalities in systemic sclerosis: a laser-Doppler and nailfold videocapillaroscopy study J. Rheumatol. 37 2010 1174 1180
    • (2010) J. Rheumatol. , vol.37 , pp. 1174-1180
    • Cutolo, M.1
  • 91
    • 68149160030 scopus 로고    scopus 로고
    • Noninvasive imaging techniques in the assessment of scleroderma spectrum disorders
    • A.K. Murray Noninvasive imaging techniques in the assessment of scleroderma spectrum disorders Arthritis Rheum. 61 2009 1103 1111
    • (2009) Arthritis Rheum. , vol.61 , pp. 1103-1111
    • Murray, A.K.1
  • 92
    • 33947364879 scopus 로고    scopus 로고
    • The effects of tadalafil on cold-induced vasoconstriction in patients with Raynaud's phenomenon
    • E.A. Friedman The effects of tadalafil on cold-induced vasoconstriction in patients with Raynaud's phenomenon Clin. Pharmacol. Ther. 81 2007 503 509
    • (2007) Clin. Pharmacol. Ther. , vol.81 , pp. 503-509
    • Friedman, E.A.1
  • 93
    • 27744564115 scopus 로고    scopus 로고
    • Sildenafil in the treatment of Raynaud's phenomenon resistant to vasodilatory therapy
    • R. Fries Sildenafil in the treatment of Raynaud's phenomenon resistant to vasodilatory therapy Circulation 112 2005 2980 2985
    • (2005) Circulation , vol.112 , pp. 2980-2985
    • Fries, R.1
  • 94
    • 84865682812 scopus 로고    scopus 로고
    • Vardenafil for the treatment of Raynaud phenomenon: A randomized, double-blind, placebo-controlled crossover study
    • E. Caglayan Vardenafil for the treatment of Raynaud phenomenon: a randomized, double-blind, placebo-controlled crossover study Arch. Intern. Med. 172 2012 1182 1184
    • (2012) Arch. Intern. Med. , vol.172 , pp. 1182-1184
    • Caglayan, E.1
  • 95
    • 70350580526 scopus 로고    scopus 로고
    • Microvascular dysfunction in diabetic foot disease and ulceration
    • C.Y. Chao, and G.L. Cheing Microvascular dysfunction in diabetic foot disease and ulceration Diabetes Metab. Res. Rev. 25 2009 604 614
    • (2009) Diabetes Metab. Res. Rev. , vol.25 , pp. 604-614
    • Chao, C.Y.1    Cheing, G.L.2
  • 96
    • 23944507285 scopus 로고    scopus 로고
    • A comparison of two laser-based methods for determination of burn scar perfusion: Laser Doppler versus laser speckle imaging
    • C.J. Stewart A comparison of two laser-based methods for determination of burn scar perfusion: laser Doppler versus laser speckle imaging Burns 31 2005 744 752
    • (2005) Burns , vol.31 , pp. 744-752
    • Stewart, C.J.1
  • 97
    • 79952702838 scopus 로고    scopus 로고
    • Noninvasive assessment of burn wound severity using optical technology: A review of current and future modalities
    • M. Kaiser Noninvasive assessment of burn wound severity using optical technology: a review of current and future modalities Burns 37 2011 377 386
    • (2011) Burns , vol.37 , pp. 377-386
    • Kaiser, M.1
  • 98
    • 47849085095 scopus 로고    scopus 로고
    • Evaluation of the vascular integrity of free flaps based on microcirculation imaging techniques
    • P. Lamby Evaluation of the vascular integrity of free flaps based on microcirculation imaging techniques Clin. Hemorheol. Microcirc. 39 2008 253 263
    • (2008) Clin. Hemorheol. Microcirc. , vol.39 , pp. 253-263
    • Lamby, P.1
  • 99
    • 84861567280 scopus 로고    scopus 로고
    • In vivo laser speckle imaging reveals microvascular remodeling and hemodynamic changes during wound healing angiogenesis
    • A. Rege In vivo laser speckle imaging reveals microvascular remodeling and hemodynamic changes during wound healing angiogenesis Angiogenesis 15 2012 87 98
    • (2012) Angiogenesis , vol.15 , pp. 87-98
    • Rege, A.1
  • 100
    • 78149350061 scopus 로고    scopus 로고
    • Peripheral mechanisms of thermoregulatory control of skin blood flow in aged humans
    • L.A. Holowatz, and W.L. Kenney Peripheral mechanisms of thermoregulatory control of skin blood flow in aged humans J. Appl. Physiol. 109 2010 1538 1544
    • (2010) J. Appl. Physiol. , vol.109 , pp. 1538-1544
    • Holowatz, L.A.1    Kenney, W.L.2
  • 101
    • 79959836017 scopus 로고    scopus 로고
    • 17β-Estradiol and progesterone independently augment cutaneous thermal hyperemia but not reactive hyperemia
    • V.E. Brunt 17β-Estradiol and progesterone independently augment cutaneous thermal hyperemia but not reactive hyperemia Microcirculation 18 2011 347 355
    • (2011) Microcirculation , vol.18 , pp. 347-355
    • Brunt, V.E.1
  • 102
    • 84155184304 scopus 로고    scopus 로고
    • Microvascular reactivity in response to smoking and oral antioxidants in humans
    • P. Henriksson Microvascular reactivity in response to smoking and oral antioxidants in humans Microcirculation 19 2012 86 93
    • (2012) Microcirculation , vol.19 , pp. 86-93
    • Henriksson, P.1
  • 103
    • 84869815016 scopus 로고    scopus 로고
    • Impact of experimental conditions on noncontact laser recordings in microvascular studies
    • G. Mahe Impact of experimental conditions on noncontact laser recordings in microvascular studies Microcirculation 19 2012 669 675
    • (2012) Microcirculation , vol.19 , pp. 669-675
    • Mahe, G.1
  • 104
    • 79651473589 scopus 로고    scopus 로고
    • Laser speckle contrast imaging accurately measures blood flow over moving skin surfaces
    • G. Mahe Laser speckle contrast imaging accurately measures blood flow over moving skin surfaces Microvasc. Res. 81 2011 183 188
    • (2011) Microvasc. Res. , vol.81 , pp. 183-188
    • Mahe, G.1


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