The human cutaneous circulation as a model of generalized microvascular function

Journal of Applied Physiology

Volumn 105, Issue 1, 2008, Pages 370-372

  Holowatz, Lacy A ^a,c   Thompson Torgerson, Caitlin S ^b   Kenney, W Larry ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b DEPARTMENT OF PATHOLOGY   (United States)

^c Women's Health and Exercise Laboratory   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID;

CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; ESSENTIAL HYPERTENSION; HUMAN; LASER DOPPLER FLOWMETRY; MEDICAL RESEARCH; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; PULSE WAVE; REVIEW; SKIN BLOOD FLOW; THERMOREGULATION; VASCULAR SMOOTH MUSCLE; VASODILATATION; BIOLOGICAL MODEL; BLOOD FLOW; FUNCTIONS OF THE SKIN AND ITS APPENDAGES; HYPERTENSION; MICROCIRCULATION; PATHOPHYSIOLOGY; PHYSIOLOGY; SKIN; VASCULAR DISEASE; VASCULARIZATION; VASOCONSTRICTION;

BODY TEMPERATURE REGULATION; HUMANS; HYPERTENSION; MICROCIRCULATION; MODELS, BIOLOGICAL; REGIONAL BLOOD FLOW; SKIN; SKIN PHYSIOLOGY; VASCULAR DISEASES; VASOCONSTRICTION; VASODILATION;

EID: 50649092934     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00858.2007     Document Type: Review

References (35)

1. Abahji TN, Nill L, Ide N, Keller C, Hoffmann U, Weiss N. Acute hyperhomocysteinemia induces microvascular and macrovascular endothelial dysfunction. Arch Med Res 38: 411-416, 2007.
2. Abularrage CJ, Sidawy AN, Aidinian G, Singh N, Weiswasser JM, Arora S. Evaluation of the microcirculation in vascular disease. J Vasc Surg 42: 574-581, 2005.
3. American Heart Association. Heart Disease and Stroke Statistics - 2006 Update. American Heart Association, 2006.
4. Boignard A, Salvat-Melis M, Carpentier PH, Minson CT, Grange L, Duc C, Sarrot-Reynauld F, Cracowski JL. Local hyperemia to heating is impaired in secondary Raynaud's phenomenon. Arthritis Res Ther 7: R1103-R1112, 2005.
5. Carberry PA, Shepherd AM, Johnson JM. Resting and maximal forearm skin blood flows are reduced in hypertension. Hypertension 20: 349-355, 1992.
6. Cohuet G, Struijker-Boudier H. Mechanisms of target organ damage caused by hypertension: therapeutic potential. Pharmacol Therap 111: 81-98, 2006.
7. Cracowski JL, Minson CT, Salvat-Melis M, Halliwill JR. Methodological issues in the assessment of skin microvascular endothelial function in humans. Trends Pharmacol Sci 27: 503-508, 2006.
8. Cui J, Arbab-Zadeh A, Prasad A, Durand S, Levine BD, Crandall CG. Effects of heat stress on thermoregulatory responses in congestive heart failure patients. Circulation 112: 2286-2292, 2005.
9. Demougeot C, Prigent-Tessier A, Bagnost T, Andre C, Guillaume Y, Bouhaddi M, Marie C, Berthelot A. Time course of vascular arginase expression and activity in spontaneously hypertensive rats. Life Sci 80: 1128-1134, 2006.
10. Green DJ, Maiorana AJ, Siong JH, Burke V, Erickson M, Minson CT, Bilsborough W, O'Driscoll G. Impaired skin blood flow response to environmental heating in chronic heart failure. Eur Heart J 27: 338-343, 2006.
11. Holowatz LA, Kenney WL. Local ascorbate administration augments NO- and non-NO-dependent reflex cutaneous vasodilation in hypertensive humans. Am J Physiol Heart Circ Physiol 293: H1090-H1096, 2007.
12. Holowatz LA, Kenney WL. Up-regulation of arginase activity contributes to attenuated reflex cutaneous vasodilatation in hypertensive humans. J Physiol 581: 863-872, 2007.
13. Holowatz LA, Thompson CS, Kenney WL. Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin. Am J Physiol Heart Circ Physiol 291: H2965-H2970, 2006.
14. Holowatz LA, Thompson CS, Kenney WL. L-Arginine supplementation or arginase inhibition augments reflex cutaneous vasodilatation in aged human skin. J Physiol 574: 573-581, 2006.
15. Izjerman RG, de Jongh RT, Beijk MA, van Weissenbruch MM, Delemarre-van de Waal HA, Serne EH, Stehouwer CD. Individuals at increased coronary heart disease risk are characterized by an impaired microvascular function in skin. Eur J Clin Invest 33: 536-542, 2003.
16. Khan F, Litchfield SJ, Stonebridge PA, Belch JJ. Lipid-lowering and skin vascular responses in patients with hypercholesterolaemia and peripheral arterial obstructive disease. Vasc Med 4: 233-238, 1999.
17. Levy BI, Ambrosio G, Pries AR, Struijker-Boudier HA. Microcirculation in hypertension: a new target for treatment? Circulation 104: 735-740, 2001.
18. Lindstedt IH, Edvinsson ML, Edvinsson L. Reduced responsiveness of cutaneous microcirculation in essential hypertension - a pilot study. Blood Pressure 15: 275-280, 2006.
19. Minson CT, Holowatz LA, Wong BJ, Kenney WL, Wilkins BW. Decreased nitric oxide- and axon reflex-mediated cutaneous vasodilation with age during local heating. J Appl Physiol 93: 1644-1649, 2002.
20. Park JB, Schiffrin EL. Small artery remodeling is the most prevalent (earliest?) form of target organ damage in mild essential hypertension. J Hypertens 19: 921-930, 2001.
21. Pierzga JM, Frymoyer A, Kenney WL. Delayed distribution of active vasodilation and altered vascular conductance in aged skin. J Appl Physiol 94: 1045-1053, 2003.
22. Rizzoni D, Palombo C, Porteri E, Muiesan ML, Kozakova M, La Canna G, Nardi M, Guelfi D, Salvetti M, Morizzo C, Vittone F, Rosei EA. Relationships between coronary flow vasodilator capacity and small artery remodelling in hypertensive patients. J Hypertens 21: 625-631, 2003.
23. Rizzoni D, Porteri E, Boari GE, De Ciuceis C, Sleiman I, Muiesan ML, Castellano M, Miclini M, Agabiti-Rosei E. Prognostic significance of small-artery structure in hypertension. Circulation 108: 2230-2235, 2003.
24. Rossi M, Carpi A. Skin microcirculation in peripheral arterial obliterative disease. Biomed Pharmacother 58: 427-431, 2004.
25. Rossi M, Carpi A, Galetta F, Franzoni F, Santoro G. The investigation of skin blood flowmotion: a new approach to study the microcirculatory impairment in vascular diseases? Biomed Pharmacother 60: 437-442, 2006.
26. Sax FL, Cannon RO, 3rd Hanson C, Epstein SE. Impaired forearm vasodilator reserve in patients with microvascular angina. Evidence of a generalized disorder of vascular function? N Engl J Med 317: 1366-1370, 1987.
27. Shamim-Uzzaman QA, Pfenninger D, Kehrer C, Chakrabarti A, Kacirotti N, Rubenfire M, Brook R, Rajagopalan S. Altered cutaneous microvascular responses to reactive hyperaemia in coronary artery disease: a comparative study with conduit vessel responses. Clin Sci (Lond) 103: 267-273, 2002.
28. Sokolnicki LA, Roberts SK, Wilkins BW, Basu A, Charkoudian N. Contribution of nitric oxide to cutaneous microvascular dilation in individuals with type 2 diabetes mellitus. Am J Physiol Endocrinol Metab 292: E314-E318, 2006.
29. Stefanovska A, Bracic M, Kvernmo HD. Wavelet analysis of oscillations in the peripheral blood circulation measured by laser Doppler technique. IEEE Trans Biomed Eng 46: 1230-1239, 1999.
30. Stewart J, Kohen A, Brouder D, Rahim F, Adler S, Garrick R, Goligorsky MS. Noninvasive interrogation of microvasculature for signs of endothelial dysfunction in patients with chronic renal failure. Am J Physiol Heart Circ Physiol 287: H2687-E2696, 2004.
31. Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 97: 2222-2229, 1998.
32. Thompson-Torgerson CS, Holowatz LA, Flavahan NA, Kenney WL. Rho kinase-mediated local cold-induced cutaneous vasoconstriction is augmented in aged human skin. Am J Physiol Heart Circ Physiol 293: H30-H36, 2007.
33. Thompson CS, Holowatz LA, Kenney WL. Cutaneous vasoconstrictor responses to norepinephrine are attenuated in older humans. Am J Physiol Regul Integr Comp Physiol 288: R1108-R1113, 2005.
34. Tousoulis D, Xenakis C, Tentolouris C, Davies G, Antoniades C, Crake T, Stefanadis C. Effects of vitamin C on intracoronary L-arginine dependent coronary vasodilatation in patients with stable angina. Heart 91: 1319-1323, 2005.
35. Wong BJ, Wilkins BW, Holowatz LA, Minson CT. Nitric oxide synthase inhibition does not alter the reactive hyperemic response in the cutaneous circulation. J Appl Physiol 95: 504-510, 2003.