An amino acid residue in the second extracellular loop determines the agonist-dependent tolerance property of the human D3 dopamine receptor

ACS Chemical Neuroscience

Volumn 4, Issue 6, 2013, Pages 940-951

  Gil Mast, Sara ^a   Kortagere, Sandhya ^b   Kota, Kokila ^a   Kuzhikandathil, Eldo V ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

D3 receptor conformation; desensitization; functional selectivity; potassium channels; signal transduction; Structure function

Indexed keywords

3,4,4A,10B TETRAHYDRO 4 PROPYL 2H,5H [1]BENZOPYRANO[4,3 B][1,4]OXAZIN 9 OL; AMINO ACID; CESIUM CHLORIDE; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; ETICLOPRIDE; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PRAMIPEXOLE; QUINPIROLE; 3,4,4A,10B-TETRAHYDRO-4-PROPYL-2H,5H-(1)BENZOPYRANO(4,3-B)-1,4-OXAZIN-9-OL; BENZOPYRAN DERIVATIVE; DOPAMINE RECEPTOR STIMULATING AGENT; OXAZINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CHIMERA; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA SEQUENCE; DRUG RECEPTOR BINDING; ELECTROPHYSIOLOGY; EXTRACELLULAR LOOP; GENETIC TRANSFECTION; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PEPTIDE MAPPING; PHARMACOPHORE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; AGONISTS; AMINO ACID SEQUENCE; ANIMAL; CELL CULTURE; CHEMISTRY; DRUG TOLERANCE; EXTRACELLULAR FLUID; GENETICS; HUMAN; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; BENZOPYRANS; CELLS, CULTURED; DOPAMINE AGONISTS; DRUG TOLERANCE; EXTRACELLULAR FLUID; HUMANS; MICE; OXAZINES; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, DOPAMINE D3;

EID: 84879762668     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn3002202     Document Type: Article

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