Development of tolerance in D3 dopamine receptor signaling is accompanied by distinct changes in receptor conformation

Biochemical Pharmacology

Volumn 79, Issue 6, 2010, Pages 897-907

  Westrich, Ligia ^a   Gil Mast, Sara ^a   Kortagere, Sandhya ^b   Kuzhikandathil, Eldo V ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Biotinylation; Desensitization; Drd3; GPCR; Modeling; Signaling

Indexed keywords

BETA ADRENERGIC RECEPTOR; CYSTEINE; DOPAMINE 3 RECEPTOR; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MUTANT PROTEIN; THIOL GROUP;

ANIMAL CELL; ARTICLE; BIOTINYLATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DESENSITIZATION; HYDROPHILICITY; HYDROPHOBICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; BIOTINYLATION; CELL LINE; COMPUTER SIMULATION; DOPAMINE; HUMANS; MICE; MODELS, BIOLOGICAL; MOLECULAR BIOLOGY; MUTATION; PATCH-CLAMP TECHNIQUES; PROTEIN CONFORMATION; RECEPTORS, DOPAMINE D3; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

EID: 74149086081     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.10.016     Document Type: Article

References (24)

1. Missale C., Nash S.R., Robinson S.W., Jaber M., and Caron M.G. Dopamine receptors: from structure to function. Physiol Rev 78 (1998) 189-225
2. Neve K.A., Seamans J.K., and Trantham-Davidson H. Dopamine receptor signaling. J Recept Signal Transduct Res 24 (2004) 165-175
3. Cussac D., Newman-Tancredi A., Pasteau V., and Millan M.J. Human dopamine D(3) receptors mediate mitogen-activated protein kinase activation via a phosphatidylinositol 3-kinase and an atypical protein kinase C-dependent mechanism. Mol Pharmacol 56 (1999) 1025-1030
4. Beom S., Cheong D., Torres G., Caron M.G., and Kim K.M. Comparative studies of molecular mechanisms of dopamine D2 and D3 receptors for the activation of extracellular signal-regulated kinase. J Biol Chem 279 (2004) 28304-28314
5. Westrich L., and Kuzhikandathil E.V. The tolerance property of human D3 dopamine receptor is determined by specific amino acid residues in the second cytoplasmic loop. Biochim Biophys Acta 1773 12 (2007) 1747-1758
6. Kuzhikandathil E.V., Yu W., and Oxford G.S. Human dopamine D3 and D2L receptors couple to inward rectifier potassium channels in mammalian cell lines. Mol Cell Neurosci 12 (1998) 390-392
7. Kuzhikandathil E.V., and Oxford G.S. Dominant-negative mutants identify a role for GIRK channels in D3 dopamine receptor-mediated regulation of spontaneous secretory activity. J Gen Physiol 115 (2000) 697-706
8. Kuzhikandathil E.V., Westrich L., Bakhos S., and Pasuit J. Identification and characterization of novel properties of the human D3 dopamine receptor. Mol Cell Neurosci 26 (2004) 144-155
9. Cherezov V., Rosenbaum D.M., Hanson M.A., Rasmussen S.G., Thian F.S., Kobilka T.S., et al. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 318 5854 (2007) 1258-1265
10. Eswar N., Marti-Renom M.A., Webb B., Madhusudhan M.S., Eramian D., Shen M., et al. Comparative protein structure modeling with MODELLER. Current protocols in bioinformatics (2000), John Wiley & Sons Inc. [Suppl. 15] p. 5.6.1-30
11. Jones G., Willett P., Glen R.C., Leach A.R., and Taylor R. Development and validation of a genetic algorithm for flexible docking. J Mol Biol 267 (1997) 727-748
12. Eldridge M.D., Murray C.W., Auton T.R., Paolinine G.V., and Mee R.P. Empirical scoring functions. I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes. J Comput Aided Mol Des 11 5 (1997) 425-445
13. Kortagere S., and Welsh W.J. Development and application of hybrid structure based method for efficient screening of ligands binding to G-protein coupled receptors. J Comput Aided Mol Des 20 12 (2006) 789-792
14. Kalé L., Skeel R., Bhandarkar M., Brunner R., Gursoy A., Krawetz N., et al. NAMD2: greater scalability for parallel molecular dynamics. J Comput Phys 151 (1999) 283-312
15. Brooks B.R., Bruccoleri R.E., Olafson B.D., States D.J., Swaminathan S., and Karplus M. CHARMM: a program for macromolecular energy, minimization, and dynamics calculations. J Comput Chem 4 (1983) 187-217
16. Humphrey W., Dalke A., and Schulten K. VMD-visual molecular dynamics. J Mol Graph 14 (1996) 33-38
17. Nielsen J.E., Andersen K.V., Honig B., Hooft R.W., Klebe G., Vriend G., et al. Improving macromolecular electrostatics calculations. Protein Eng 12 8 (1999) 657-662
18. Li H., Robertson A.D., and Jensen J.H. Very fast empirical prediction and rationalization of protein pKa values. Proteins 61 4 (2005) 704-721
19. Nebane N.M., Hurst D.P., Carrasquer C.A., Qiao Z., Reggio P.H., and Song Z.H. Residues accessible in the binding-site crevice of transmembrane helix 6 of the CB2 cannabinoid receptor. Biochemistry 47 52 (2008) 13811-13821
20. Liapakis G., Simpson M.M., and Javitch JA. The substituted-cysteine accessibility method (SCAM) to elucidate membrane protein structure. Curr Protoc Neurosci (1999) Supplement 8, Chap. 4, Unit 4.15, pp. 4.15.1-4.15.10.
21. Gainetdinov R.R., Premont R.T., Bohn L.M., Lefkowitz R.J., and Caron M.G. Desensitization of G protein-coupled receptors and neuronal functions. Ann Rev Neurosci 27 (2004) 107-144
22. Lefkowitz R.J. G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization. J Biol Chem 273 (1998) 18677-18680
23. Ferguson S.S. Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol Rev 53 (2001) 1-24
24. Kim K.M., Valenzano K.J., Robinson S.R., Yao W.D., Barak L.S., and Caron M.G. Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins. J Biol Chem 276 (2001) 37409-37414