Second-phase validation study of short time exposure test for assessment of eye irritation potency of chemicals

Toxicology in Vitro

Volumn 27, Issue 6, 2013, Pages 1855-1869

  Kojima, Hajime ^a   Hayashi, Kazuhiko ^b   Sakaguchi, Hitoshi ^b   Omori, Takashi ^c   Otoizumi, Takuya ^c   Sozu, Takashi ^d   Kuwahara, Hirofumi ^e   Hayashi, Takumi ^e   Sakaguchi, Mayumi ^f   Toyoda, Akemi ^f   Goto, Haruka ^f   Watanabe, Shinichi ^g   Ahiko, Kyoko ^g   Nakamura, Tsuneaki ^g   Morimoto, Takashi ^h  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b KAO CORPORATION   (Japan)

^c DOSHISHA UNIVERSITY   (Japan)

^d KYOTO UNIVERSITY   (Japan)

^e KANEBO LTD   (Japan)

^f POLA CHEMICAL INDUSTRIES INC   (Japan)

^g LION CORPORATION   (Japan)

^h SUMITOMO CHEMICAL CO LTD   (Japan)

Author keywords

Alternative method; Eye irritation; GHS; SIRC cells; STE; Validation

Indexed keywords

1,3 PHENYLENEDIAMINE; 2 METHYLBUTYRIC ACID; 2 PHENOXYETHANOL; 2 PROPANOL; ACETIC ACID ETHYL ESTER; ACETONE; AMMONIUM NITRATE; BENZALKONIUM CHLORIDE; BUTANOL; BUTYROLACTONE; CETYLPYRIDINIUM SALT; CITRIC ACID; CYCLOHEXANONE; DODECYL SULFATE SODIUM; ETHANOLAMINE; GLYCEROL; IMIDAZOLE; ISOBUTANOL; ISOBUTYRALDEHYDE; MACROGOL 400; MYRISTIC ACID ISOPROPYL ESTER; MYRISTYL ALCOHOL; OCTANOL; PROMETHAZINE; PROPYLENE GLYCOL; PYRIDINE; SALICYLATE SODIUM; SORBATE POTASSIUM; TRITON X 100; UNINDEXED DRUG;

ACCURACY; ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG POTENCY; EYE IRRITATION; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; INTERRATER RELIABILITY; INTRARATER RELIABILITY; NONHUMAN; PREDICTIVE VALUE; REPRODUCIBILITY; SHORT TIME EXPOSURE TEST; VALIDATION STUDY; VOLATILIZATION;

ALTERNATIVE METHOD; EYE IRRITATION; GHS; SIRC CELLS; STE; VALIDATION;

ANIMAL TESTING ALTERNATIVES; ANIMALS; CELL LINE; CORNEA; IRRITANTS; RABBITS; REPRODUCIBILITY OF RESULTS; TOXICITY TESTS, ACUTE;

EID: 84879749412     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2013.05.013     Document Type: Article

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