Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart

Journal of Molecular and Cellular Cardiology

Volumn 28, Issue 9, 1996, Pages 2005-2016

  Olivetti, Giorgio ^a   Quaini, Federico ^b   Sala, Roberto ^b   Lagrasta, Costanza ^b   Corradi, Domenico ^b   Bonacina, Edgardo ^c   Gambert, Steven R ^a   Cigola, Elena ^a   Anversa, Piero ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF PARMA   (Italy)

^c OSPEDALE NIGUARDA CA GRANDA   (Italy)

Author keywords

Apoptosis; Border zone; DNA laddering; DNA strand breaks; Human heart; Myocardial infarction

Indexed keywords

DNA; DNA FRAGMENT; DNA NUCLEOTIDYLEXOTRANSFERASE;

ACUTE HEART INFARCTION; ADULT; AGAR GEL ELECTROPHORESIS; AGED; APOPTOSIS; ARTICLE; CELL NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; DNA STRAND BREAKAGE; FEMALE; HEART MUSCLE CELL; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL;

EID: 0030249340     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1996.0193     Document Type: Article

References (43)

1. ANVERSA P, OLIVETTI G, MEGGS LG, SONNENBLICK EH, CAPASSO JM, 1993. Cardiac anatomy and ventricular loading after myocardial infarction. Circulation 87 [Suppl. VII]: 22-27.
2. ANVERSA P, SONNENBLICK EH, 1990. Ischemic cardiomyopathy. Prog Cardiovasc Dis 33: 49-70.
3. BELTRAMI CA, FINATO N, ROCCO M, FERUGLIO GA, PURICELLI C, CIGOLA E, QUAINI F, SONNENBLICK EH, OLIVETTI G, ANVERSA P, 1994. Structural basis of end-stage failure in ischemic cardiomyopathy in humans. Circulation 89: 151-163.
4. BURSCH W, OBERHAMMER F, SCHULTE-HERMANN R, 1992. Cell death by apoptosis and its protective role against disease. Trends Pharmacol Sci 13: 245-251.
5. CAPASSO JM, BRUNO S, CHENG W, LI P, RODGERS R, DARZYNKIEWICZ Z, ANVERSA P, 1992. Ventricular loading is coupled with DNA synthesis in adult cardiac myocytes after acute and chronic myocardial infarction in rats. Circ Res 71: 1379-1389.
6. CAPASSO JM, JEANTY MW, PALACKAL T, OLIVETTI G, ANVERSA P, 1989. Ventricular remodeling induced by acute nonocclusive constriction of coronary artery in rats. Am J Physiol 257: H1983-H1993.
7. CAULFIELD JB, LEINBACH R, GOLD H, 1976. The relationship of myocardial infarct size and prognosis. Circulation 53 (Suppl I): 141-145.
8. CHENG W, LI B, KAJSTURA J, LI P, WOLIN MS, SONNENBLICK EH, HINTZE TH, OLIVETTI G, ANVERSA P, 1995. Stretch-induced programmed myocyte cell death. J Clin Invest 96: 2247-2259.
9. CLARK EB, 1984. Functional aspects of cardiac development. In: Growth of the Heart in Health and Disease, Radovan Zak, ed. Raven Press, New York, pp 81-103.
10. COX JL, MCLAUGHLIN VW, FLOWERS NC, HORAN LG, 1968. The ischemic zone surrounding acute myocardial infarction. Its morphology as detected by dehydrogenase staining. Am Heart J 76: 650-659.
11. DARZYNKIEWICZ Z, BRUNO S, DEL BINO G, GORCZYCA W, HOTZ MA, LASSOTA P, TRAGANOS F, 1992. Feature of apoptotic cells measured by flow cytometry. Cytometry 13: 795-808.
12. FACTOR SM, SONNENBLICK EH, KIRK ES, 1978. The histologic border zone of acute myocardial infarction -islands or peninsulas? Am J Pathol 92: 111-124.
13. FACTOR SM, FLOMENBAUM M, ZHAO MJ, ENG C, ROBINSON TF, 1988. The effects of acutely increased ventricular cavity pressure on intrinsic myocardial connective tissue. J Am Coll Cardiol 12: 1582-1589.
14. GINZTON LE, CONANT R, RODRIGUES DM, LAKS MM, 1989. Functional significance of hypertrophy of the non-infarcted myocardium after myocardial infarction in humans. Circulation 80: 816-822.
15. GOTTLIEB RA, BURLESON KO, KLONER RA, BABLOR BM, ENGLER RL, 1994. Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest 94: 1621-1628.
16. GRAJEK S, LESIAK M, PYDA M, ZAJAC M, PARADOWSKI S, KACZMAREK E, 1993. Hypertrophy or hyperplasia in cardiac muscle: post-mortem human morphometric study. Eur Heart J 14: 40-47.
17. HEARSE DJ, YELLON DM, 1981. The border zone in evolving myocardial infarction: controversy or confusion? Am J Cardiol 47: 1321-1334.
18. HEARSE DJ, OPIE LH, KATZEFF IE, LUBBE WF, VAN DER WERFF TJ, PEISACH M, BOULLE G, 1977. Characterization of the "border zone" in acute regional ischemia in the dog. Am J Cardiol 40: 716-726.
19. ITOH G, TAMURA J, SUZUKI M, SUZUKI Y, IKEDA H, KOIKE M, NOMURA M, JIE T, ITO K, 1995. DNA fragmentation of human infarcted myocardial cells demonstrated by the nick end labeling method and DNA agarose gel electrophoresis. Am J Pathol 146: 1325-1331.
20. KAJSTURA J, ZHANG X, REISS K, SZOKE E, LI P, LAGRASTA C, CHENG W, DARZYNKIEWICZ Z, OLIVETTI G, ANVERSA P, 1994. Myocyte cellular hyperplasia and myocyte cellular hypertrophy contribute to chronic ventricular remodeling in coronary artery narrowing-induced cardiomyopathy in rats. Circ Res 74: 383-400.
21. KAJSTURA J, MANSUKHANI M, CHENG W, REISS K, KRAJEWSKI S, REED JC, QUAINI F, SONNENBLICK EH, ANVERSA P, 1995. Programmed cell death and the expression of the protooncogene Bcl-2 in myocyte during post-natal maturation of the heart. Exp Cell Res 219: 110-121.
22. KAJSTURA J, CHENG W, REISS K, CLARK WA, SONNENBLICK EH, KRAJEWSKI S, REED JC, OLIVETTI G, ANVERSA P, 1996. Apoptotic and necrotic myocyte cell death are independent contributing variables of infarct size in rats. Lab Invest 74: 86-107.
23. OLIVETTI G, ANVERSA P, LOUD A, 1980. Morphometric study of early postnatal development in the left and right ventricular myocardium of the rat. II. Tissue composition, capillary growth, and sarcoplasmic alterations. Circ Res 46: 503-512.
24. OLIVETTI G, RICCI R, BEGHI C, GUIDERI G, ANVERSA P, 1986. Response of the border zone to myocaridal infarction in rats. Am J Pathol 125: 476-483.
25. OLIVETTI G, CAPASSO JM, SONNENBLICK EH, ANVERSA P, 1990. Side-to-side slippage of myocytes participates in ventricular wall remodeling acutely after myocardial infarction in rats. Circ Res 67: 23-34.
26. PAGE E, POLIMENI PI, 1977. Ultrastructural changes in the ischemic zone bordering experimental infarcts in rat left ventricles. Am J Pathol 87: 81-104.
27. PFEFFER MA, BRAUNWALD E, 1990. Ventricular remodeling after myocardial infarction. Circulation 81: 1161-1172.
28. QUAINI F, CIGOLA E, LAGRASTA C, SACCANI G, QUAINI E, ROSSI C, OLIVETTI G, ANVERSA P, 1994. End-stage cardiac failure in humans is coupled with the induction of proliferating cell nuclear antigen and nuclear mitotic division in ventricular myocytes. Circ Res 75: 1050-1063.
29. REIMER KA, JENNINGS RB, 1986. Myocardial ischemia, hypoxia and infarction. In: The Heart and Cardiovascular System. HA Fozzard, E Haber, RB Jennings, AM Katz, HE Morgan, eds. New York, Raven Press, pp 1133-1201.
30. REISS K, KAJSTURA J, ZHANG X, LI P, SZOKE E, OLIVETTI G, ANVERSA P, 1994. Acute myocardial infarction leads to upregulation of the IGF-1 autocrine system, DNA replication and nuclear mitotic division in the remaining viable cardiac myocytes. Exp Cell Res 213: 463-472.
31. RESNICOFF M, ABRAHAM D, YUTANAWIBOONCHAI W, ROTMAN HL, KAJSTURA J, RUBIN R, ZOLTICK P, BASERGA R, 1995. The insulin-like growth factor 1 receptor protects tumor cells from apoptosis in vivo. Cancer Res 55: 2463-2469.
32. ROSS J JR., 1976. Electrocardiographic ST-segment analysis in the characterization of myocardial ischemia and infarction. Circulation 52: 73-81.
33. ROSS J, SONNENBLICK EH, TAYLOR RR, SPOTNITZ HM, COVELL JW, 1971. Diastolic geometry and sarcomere lengths in the chronically dilated canine left ventricle. Circ Res 28: 49-61.
34. SHAROV VG, SABBAH HN, SHIMOYAMA H, GOUSSEV AV, LESCH M, GOLDSTEIN S, 1966. Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure. Am J Pathol 148: 141-149.
35. SPOTNITZ HM, SPOTNITZ WD, COTTRELL TS, SPIRO D, SONNENBLICK EH, 1974. Cellular basis for volume related wall thickness changes in the rat left ventricle. J Mol Cell Cardiol 6: 317-331.
36. TAKEDA K, YU Z, NISHIKAWA T, TANAKA M, HOSODA S, FERRANS VJ, KASAJIMA T, 1996. Apoptosis and DNA fragmentation in the bulbus cordis of the developing heart. J Mol Cell Cardiol 28: 208-213.
37. TANAKA M, ITO H, ADACHI S, AKIMOTO H, NISHIKAWA T, KASAJIMA T, MARUMO F, HIROE M, 1994. Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes. Circ Res 75: 426-433.
38. VITALI-MAZZA L, ANVERSA P, TEDESCHI F, MASTANDREA R, MAVILLA V, VISIOLI O, 1972. Ultrastructural basis of acute left ventricular failure from severe acute stenosis in the rabbit. J Mol Cell Cardiol 4: 661-671.
39. WALLENSTEIN S, ZUCKER CL, FLEISS JL, 1980. Some statistical methods used in circulation research. Circ Res 47: 1-9.
40. WEISMAN HF, BUSH DE, MANNISI JA, WEISFELDT ML, HEALEY B, 1988. Cellular mechanisms of myocardial infarct expansion. Circulation 78: 186-201.
41. WYLLIE AH, 1992. Apoptosis and the regulation of cell numbers in normal and neoplastic tissue: an overview. Cancer Metast Rev 11: 95-103.
42. YAMAWAKI M, ZURBRIGGEN A, RICHARD A, VANDEVELDE M, 1993. Saponin treatment for in situ hybridization maintains good morphological preservation. J Histochem Cytochem 41: 105-109.
43. ZHAO MJ, ZHANG H, ROBINSON TF, FACTOR SM, SONNENBLICK EH, ENG C, 1987. Profound structural alterations of the extracellular collagen matrix in postischemic dysfunctional ("stunned") but viable myocardium. J Am Coll Cardiol 10: 1322-1334.