ROS and ERK1/2-mediated caspase-9 activation increases XAF1 expression in dexamethasone-induced apoptosis of EBV-transformed B cells

International Journal of Oncology

Volumn 43, Issue 1, 2013, Pages 29-38

  Park, Ga Bin ^a   Choi, Yunock ^a   Kim, Yeong Seok ^a   Lee, Hyun Kyung ^b   Kim, Daejin ^a   Hur, Dae Young ^a  

^a Inje University College of Medicine   (South Korea)

^b Inje University College of Medicine   (South Korea)

Author keywords

Apoptosis; B cell; Bax; Dexamethasone; Epstein Barr virus; ERK1 2; Puma; Reactive oxygen species; X linked inhibitor of apoptosis associated factor 1

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE 9 INHIBITOR; DEXAMETHASONE; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BAX; PUMA PROTEIN; REACTIVE OXYGEN METABOLITE; X LINKED INHIBITOR OF APOPTOSIS;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CANCER INHIBITION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME METABOLISM; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; UPREGULATION;

ANIMALS; APOPTOSIS; B-LYMPHOCYTES; BCL-2-ASSOCIATED X PROTEIN; CALLITHRIX; CASPASE 8; CASPASE 9; CELL LINE; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DEXAMETHASONE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HERPESVIRUS 4, HUMAN; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE SIGNALING SYSTEM; MITOCHONDRIA; NEOPLASM PROTEINS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; UP-REGULATION;

EID: 84879671098     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.1949     Document Type: Article

References (33)

1. Young LS and Rickinson AB: Epstein-Barr virus: 40 years on. Nat Rev Cancer 4: 757-768, 2004. (Pubitemid 39331148)
2. Kuppers R: B cells under influence: transformation of B cells by Epstein-Barr virus. Nat Rev Immunol 3: 801-812, 2003.
3. Lopez-Royuela N, Balsas P, Galan-Malo P, Anel A, Marzo I and Naval J: Bim is the key mediator of glucocorticoid-induced apoptosis and of its potentiation by rapamycin in human myeloma cells. Biochim Biophys Acta 1803: 311-322, 2010.
4. Laane E, Panaretakis T, Pokrovskaja K, et al: Dexamethasone-induced apoptosis in acute lymphoblastic leukemia involves differential regulation of Bcl-2 family members. Haematologica 92: 1460-1469, 2007. (Pubitemid 350144120)
5. Li Z, Chen Y, Cao D, Wang Y, Chen G, Zhang S and Lu J: Glucocorticoid upregulates transforming growth factor-β (TGF-β) type II receptor and enhances TGF-β signaling in human prostate cancer PC-3 cells. Endocrinology 147: 5259-5267, 2006. (Pubitemid 44790581)
6. Li M, Chen F, Liu CP, Li DM, Li X, Wang C and Li JC: Dexamethasone enhances trichosanthin-induced apoptosis in the HepG2 hepatoma cell line. Life Sci 86: 10-16, 2010.
7. Dobos J, Kenessey I, Timar J and Ladanyi A: Glucocorticoid receptor expression and antiproliferative effect of dexamethasone on human melanoma cells. Pathol Oncol Res 17: 729-734, 2011.
8. Yamamoto T, Nishiguchi M, Ioue N, et al: Inhibition of murine osteosarcoma cell proliferation by gluocorticoid. Anticancer Res 22: 4151-4156, 2002. (Pubitemid 36134448)
9. Greenberg AK, Hu J, Basu S, et al: Glucocorticoids inhibit lung cancer cell growth through both the extracellular signal-related kinase pathway and cell cycle regulators. Am J Respir Cell Mol Biol 27: 320-328, 2002. (Pubitemid 34979290)
10. Wang H, Wang Y, Rayburn ER, Hill DL, Rinehart JJ and Zhang R: Dexamethasone as a chemosensitizer for breast cancer chemotherapy: potentiation of the antitumor activity of adriamycin, modulation of cytokine expression, and pharmacokinetics. Int J Oncol 30: 947-953, 2007.
11. Xu MJ, Fang GE, Liu YJ and Song LN: Effects of glucocorticoid on proliferation, differentiation, and glucocorticoid receptor expression in human ovarian carcinoma cell line 3AO. Acta Pharmacol Sin 23: 819-823, 2002.
12. Liston P, Fong WG, Kelly NL, et al: Identification of XAF1 as an antagonist of XIAP anti-Caspase activity. Nat Cell Biol 3: 128-133, 2001. (Pubitemid 32118365)
13. Wang J, He H, Yu L, et al: HSF1 down-regulates XAF1 through transcriptional regulation. J Biol Chem 281: 2451-2459, 2006. (Pubitemid 43845704)
14. Fong WG, Liston P, Rajcan-Separovic E, St Jean M, Craig C and Korneluk RG: Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines. Genomics 70: 113-122, 2000.
15. Byun DS, Cho K, Ryu BK, Lee MG, Kang MJ, Kim HR and Chi SG: Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas. Cancer Res 63: 7068-7075, 2003. (Pubitemid 37413441)
16. Tu SP, Sun YW, Cui JT, et al: Tumor suppressor XIAP-associated factor 1 (XAF1) cooperates with tumor necrosis factor-related apoptosis-inducing ligand to suppress colon cancer growth and trigger tumor regression. Cancer 116: 1252-1263, 2010.
17. Huang J, Yao WY, Zhu Q, Tu SP, Yuan F, Wang HF, Zhang YP and Yuan YZ: XAF1 as a prognostic biomarker and therapeutic target in pancreatic cancer. Cancer Sci 101: 559-567, 2010.
18. Lee MG, Huh JS, Chung SK, et al: Promoter CpG hypermethylation and downregulation of XAF1 expression in human urogenital malignancies: implication for attenuated p53 response to apoptotic stresses. Oncogene 25: 5807-5822, 2006.
19. Straszewski-Chavez SL, Visintin IP, Karassina N, et al: XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway. J Biol Chem 282: 13059-13072, 2007. (Pubitemid 47100639)
20. Martelli AM, Cappellini A, Tazzari PL, et al: Caspase-9 is the upstream caspase activated by 8-methoxypsoralen and ultraviolet-A radiation treatment of Jurkat T leukemia cells and normal T lymphocytes. Haematologica 89: 471-479, 2004. (Pubitemid 38798552)
21. Park GB, Kim YS, Lee HK, Song H, Cho DH, Lee WJ and Hur DY: Endoplasmic reticulum stress-mediated apoptosis of EBV-transformed B cells by cross-linking of CD70 is dependent upon generation of reactive oxygen species and activation of p38 MAPK and JNK pathway. J Immunol 185: 7274-7284, 2010.
22. Matsuzawa A and Ichijo H: Stress-responsive protein kinases in redox-regulated apoptosis signaling. Antioxid Redox Signal 7: 472-481, 2005. (Pubitemid 40279816)
23. Chiu WH, Luo SJ, Chen CL, et al: Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells. Biochem Pharmacol 83: 1159-1171, 2012.
24. Baghdassarian N, Catallo R, Mahly MA, French P, Chizat F, Bryon PA and French M: Glucocorticoids induce G1 as well as S-phase lengthening in normal human stimulated lymphocytes: differential effects on cell cycle regulatory proteins. Exp Cell Res 240: 263-273, 1998. (Pubitemid 28371107)
25. Ramalingam A, Hirai A and Thompson EA: Glucocorticoid inhibition of fibroblast proliferation and regulation of the cyclin kinase inhibitor p21Cip1. Mol Endocrinol 11: 577-586, 1997. (Pubitemid 27193793)
26. Gupta S: Molecular signaling in death receptor and mitochondrial pathways of apoptosis. Int J Oncol 22: 15-20, 2003.
27. Canton M, Caffieri S, Dall'Acqua F and Di Lisa F: PUVA-induced apoptosis involves mitochondrial dysfunction caused by the opening of the permeability transition pore. FEBS Lett 522: 168-172, 2002. (Pubitemid 34722518)
28. Wang J, Zhang W, Zhang Y, et al: c-Jun N-terminal kinase (JNK1) upregulates XIAP-associated factor 1 (XAF1) through interferon regulatory factor 1 (IRF-1) in gastrointestinal cancer. Carcinogenesis 30: 222-229, 2009.
29. Melino G, Bernassola F, Ranalli M, et al: p73 induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J Biol Chem 279: 8079-8083, 2004.
30. Roman M, Chen W and Cobb MH: Differential regulation and properties of MAPKs. Oncogene 26: 3100-3112, 2007. (Pubitemid 46763006)
31. Zhang W and Liu HT: MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res 12: 9-18, 2002.
32. Desbarats J, Birge RB, Mimouni-Rongy M, Weinstein DE, Palerme JS and Newell MK: Fas engagement induces neurite growth through ERK activation and p35 upregulation. Nat Cell Biol 5: 118-125, 2003. (Pubitemid 36204194)
33. Zhuang S and Schnellmann RG: A death-promoting role for extracellular signal-regulated kinase. J Pharmacol Exp Ther 319: 991-997, 2006. Welfare and Family Affairs