Glucocorticoids induce G1 as well as S-phase lengthening in normal human stimulated lymphocytes: Differential effects on cell cycle regulatory proteins

Experimental Cell Research

Volumn 240, Issue 2, 1998, Pages 263-273

  Baghdassarian, Nathalie ^a   Catallo, Régine ^a   Mahly, Mohamed A ^a   Ffrench, Patrick ^b   Chizat, Florence ^a   Bryon, Paul A ^a,b   Ffrench, Martine ^a,b  

^a UNIVERSITÉ LYON 1   (France)

^b EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; REGULATOR PROTEIN;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; DRUG EFFECT; GROWTH REGULATION; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN ANALYSIS;

EID: 0031826570     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1998.3942     Document Type: Article

References (34)

1. Wyllie A. H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature. 284:1980;555-556.
2. Ernst P., Killmann S-A. Perturbation of generation cycle of human leukemic blast cells by cytostatic therapy in vivo: Effect of corticosteroids. Blood. 36:1970;689-696.
3. Rupprecht R., Wodarz N., Kornhuber J., Schmitz B., Wild K., Braner H. U., Müller O. A., Riederer P. In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in man: Relationship to glucocorticoid receptors. Neuropsychobiology. 24:1990;61-66.
4. Fagot D., Buquet-Fagot C., Mester J. Antimitogenic effects of dexamethasone in chemically transformed mouse fibroblasts. Endocrinology. 129:1991;1033-1041.
5. 3cell cycle. J. Steroid Biochem. 28:1987;345-347.
6. Cidlowski J. A., Cidlowski N. B. Glucocorticoid receptors and the cell cycle: Evidence that the accumulation of glucocorticoid receptors during the S phase of the cell cycle is dependent on ribonucleic acid and protein synthesis. Endocrinology. 110:1982;1653-1662.
7. Crabtree G. R. Contingent genetic regulatory events in T lymphocyte activation. Science. 243:1989;355-361.
8. Peter M., Herskowitz I. Joining the complex: Cyclin-dependent kinase inhibitory proteins and the cell cycle. Cell. 79:1994;181-184.
9. 1cyclins. Cell. 73:1993;1059-1065.
10. Tsai L-H., Harlow E., Meyerson M. Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature. 353:1991;174-177.
11. Draetta G., Piwnica-Worms H., Morrison D., Druker B., Roberts T., Beach D. Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature. 336:1988;738-744.
12. Modiano J. F., Domenico J., Szepesi A., Lucas J. J., Gelfand E. W. Differential requirements for interleukin-2 distinguish the expression and activity of the cyclin-dependent kinases Cdk4 and Cdk2 in human T cells. J. Biol. Chem. 269:1994;32972-32978.
13. 1phase in primary human T lymphocytes. J. Biol. Chem. 268:1993;4113-4119.
14. kip1cyclin-dependent kinase inhibitor prevented by rapamycin. Nature. 372:1994;570-573.
15. Jansen-Dürr P., Meichle A., Steiner P., Pagano M., Finke K., Botz J., Wessbecher J., Draetta G., Eilers M. Differential modulation of cyclin gene expression by MYC. Proc. Natl. Acad. Sci. USA. 90:1993;3685-3689.
16. cdc2and cyclin-dependent kinase-2 in T lymphocytes. J. Immunol. 152:1994;4328-4335.
17. Eastman-Recks S. B., Vedeckis W. V. Glucocorticoid inhibition of c-myc, c-myb, c-ki-ras in a mouse lymphoma cell line. Cancer Res. 46:1986;2457-2462.
18. Yuh Y. S., Thompson E. B. Glucocorticoid effect on oncogene/growth gene expression in human T lymphoblastic leukemic cell line CCRF-CEM. J. Biol. Chem. 264:1989;10904-10910.
19. Rhee K., Bresnahan W., Hirai A., Hirai M., Thompson E. A. c-Myc and cyclin D3 (CcnD3) genes are independent targets for glucocorticoid inhibition of lymphoid cell proliferation. Cancer Res. 55:1995;4188-4195.
20. 1) lymphocytes. J. Immunol. 132:1984;261-265.
21. Boumpas D. T., Anastassiou E. D., Older S. A., Tsokos G. C., Nelson D. L., Balow J. E. Dexamethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription. J. Clin. Invest. 87:1991;1739-1747.
22. 1cyclin-dependent kinase genes in lymphoid cells. Cell Growth Differ. 6:1995;691-698.
23. Perrin-Wolff M., Bertoglio J., Bressac B., Bohuon C., Pallardy M. Structure-activity relationships in glucocorticoid-induced apoptosis in T-lymphocytes. Biochem. Pharmacol. 50:1995;103-110.
24. Darzynkiewicz Z., Bruno S., Del Biro G., Gorezyca W., Motz M. A., Lassota P., Traganos F. Features of apoptotic cells measured by flow cytometry. Cytometry. 13:1992;795-808.
25. Shibui S., Hoshino T., Vanderlaan M., Gray J. W. Double labeling with iodo- and bromodeoxyuridine for cell kinetics studies. J. Histochem. Cytochem. 37:1989;1007-1011.
26. Tam S. W., Shay J. W., Pagano M. Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16(Ink4). Cancer Res. 54:1994;5816-5820.
27. Oakley R. H., Cidlowski J. A. Homologous down regulation of the glucocorticoid receptor: The molecular machinery. Crit. Rev. Eukaryot. Gene. Expr. 3:1993;63-68.
28. Meyerson M., Enders G. H., Wu C. L., Su L. K., Gorka C., Nelson C., Harlow E., Tsai L. H. A family of human cdc2-related protein kinases. EMBO J. 11:1992;2909-2917.
29. Meyerson M., Harlow E. Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol. Cell. Biol. 14:1994;2077-2086.
30. Rhee K., Thompson E. A. Glucocorticoid regulation of a transcription factor that binds an initiator-like element in the murine thymidine kinase (Tk-1) promoter. Mol. Endocrinol. 10:1996;1536-1548.
31. Reisman D., Thompson E. A. Glucocorticoid regulation of cyclin D3 gene transcription and mRNA stability in lymphoid cells. Mol. Endocrinol. 9:1995;1500-1509.
32. Paliogianni F., Ahuja S. S., Balow J. E., Boumpas D. T. Novel mechanism for inhibition of human T cells by glucocorticoids. J. Immunol. 151:1993;4081-4089.
33. Ohtani K., De Gregori J., Nevins J. R. Regulation of the cyclin E gene by transcription factor E2F1. Proc. Natl. Acad. Sci. USA. 92:1995;12146-12150.
34. Kip1, a cyclin dependent kinase inhibitor and a potential mediator of extra cellular antimitogenic signals. Cell. 78:1994;59-66.