Abnormal interaction of oligomeric amyloid-β with phosphorylated tau: Implications to synaptic dysfunction and neuronal damage

Journal of Alzheimer's Disease

Volumn 36, Issue 2, 2013, Pages 285-295

  Manczak, Maria ^a   Reddy, P Hemachandra ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Amyloid ; amyloid protein precursor; cognitive decline; phosphorylated tau; synapses

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; TAU PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CELL FUNCTION; CELL STRUCTURE; CONTROLLED STUDY; DISEASE COURSE; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOHISTOLOGY; IMMUNOREACTIVITY; MENTAL DETERIORATION; MOUSE; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SYNAPSE;

EID: 84879656519     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-130275     Document Type: Article

References (30)

1. Selkoe DJ (2001) Alzheimer's disease: Genes, proteins, and therapy. Physiol Rev 81, 741-766 (Pubitemid 32267077)
2. Mattson MP (2004) Pathways towards and away from Alzheimer's disease. Nature 430, 631-639 (Pubitemid 39061671)
3. LaFerla FM, Green KN, Oddo S (2007) Intracellular amyloidbeta in Alzheimer's disease. Nat Rev Neurosci 8, 499-509
4. Reddy PH, Manczak M, Mao P, Calkins MJ, Reddy AP, Shirendeb U (2010) Amyloid-beta and mitochondria in aging and Alzheimer's disease: Implications for synaptic damage and cognitive decline. J Alzheimers Dis 20(Suppl 2), S499-S512
5. Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y, Casadesus G, Zhu X (2008) Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci U S A 105, 19318-19323
6. Wang X, Su B, Lee HG, Li X, Perry G, Smith MA, Zhu X (2009) Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci 29, 9090-9103
7. Du H, Guo L, Yan S, Sosunov AA, McKhann GM, Yan SS (2010) Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A 107, 18670-18675
8. Du H, Guo L, Yan SS (2012) Synaptic mitochondrial pathology in Alzheimer's disease. Antioxid Redox Signal 16, 1467-1475
9. Swerdlow RH (2011) Brain aging, Alzheimer's disease, and mitochondria. Biochim Biophys Acta 1812, 1630-1639
10. Zhu X, Perry G, Smith MA, Wang X (2013) Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. J Alzheimers Dis 33(Suppl 1), S253-S262
11. Reddy PH, Tripathi R, Troung Q, Tirumala K, Reddy TP, Anekonda V, Shirendeb UP, Calkins MJ, Reddy AP, Mao P, Manczak M (2012) Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-Targeted antioxidant therapeutics. Biochim Biophys Acta 1822, 639-649
12. Querfurth HW, LaFerla FM (2010) Alzheimer's disease. N Engl J Med 362, 329-344
13. LaFerla FM (2010) Pathways linking Abeta and tau pathologies. Biochem Soc Trans 38, 993-995
14. Chabrier MA, Blurton-Jones M, Agazaryan AA, Nerhus JL, Martinez-Coria H, LaFerla FM (2012) Soluble A promotes wild-Type tau pathology in vivo. J Neurosci 32, 17345-17350
15. Reddy PH (2011) Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease. Brain Res 1415, 136-148
16. Brandt R, Hundelt M, Shahani N (2005) Tau alteration and neuronal degeneration in tauopathies: Mechanisms and models. Biochim Biophys Acta 1739 331-354 (Pubitemid 40018549)
17. Ittner LM, Götz J (2011) Amyloid-And tau-A toxic pas de deux in Alzheimer's disease. Nat Rev Neurosci 12, 65-72
18. Vossel KA, Zhang K, Brodbeck J, Daub AC, Sharma P, Finkbeiner S, Cui B, Mucke L (2010) Tau reduction prevents Abeta-induced defects in axonal transport. Science 330, 198
19. Smith MA, Siedlak SL, Richey PL, Mulvihill P, Ghiso J, Frangione B, Tagliavini F, Giaccone G, Bugiani O, Praprotnik D, Kalaria R, Perry G (1995) Tau protein directly interacts with the amyloid beta-protein precursor: Implications for Alzheimer's disease. Nat Med 1, 365-369
20. Delacourte A, Sergeant N, Champain D, Wattez A, Maurage CA, Lebert F, Pasquier F, David JP (2002) Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease. Neurology 59, 398-407 (Pubitemid 34857933)
21. Fein JA, Sokolow S, Miller CA, Vinters HV, Yang F, Cole GM, Gylys KH (2008) Co-Localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes. Am J Pathol 172, 1683-1692 (Pubitemid 351793359)
22. Takahashi RH, Capetillo-Zarate E, Lin MT, Milner TA, Gouras GK (2010) Co-occurrence of Alzheimer's disease-Amyloid and τ pathologies at synapses. Neurobiol Aging 31, 1145-1152
23. Manczak M, Calkins MJ, Reddy PH (2011) Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: Implications for neuronal damage. Hum Mol Genet 20, 2495-2509
24. Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274, 99-102 (Pubitemid 26332733)
25. Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH,Wang R, Seeger M, Levey AI, Gandy SE, Copeland NG, Jenkins NA, Price DL, Younkin SG, Sisodia SS (1996) Familial Alzheimer's disease-Linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 17, 1005-1013 (Pubitemid 26424026)
26. Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM (2003) Triple-Transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction. Neuron 39, 409-421 (Pubitemid 36937044)
27. Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG (2003) Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300, 486-489 (Pubitemid 36444329)
28. Miller Y, Ma B, Nussinov R. Synergistic interactions between repeats in tau protein andA amyloids may be responsible for accelerated aggregation via polymorphic states. Biochemistry 50, 5172-5181
29. Guo JP, Arai T, Miklossy J, McGeer PL (2006) Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease. Proc Natl Acad Sci U S A 103, 1953-1958 (Pubitemid 43228799)
30. Manczak M, Reddy PH (2012) Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease. Hum Mol Genet 21, 5131-5146