Inhibition of PP2A and the consequent activation of JNK/c-Jun are involved in tributyltin-induced apoptosis in human amnionic cells

Environmental Toxicology

Volumn 28, Issue 7, 2013, Pages 390-400

  Zhang, Yali ^a   Liang, Jing ^a   Sun, Lijun ^b   Guo, Zonglou ^c   Xu, Lihong ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

Apoptosis; Caspase 3; MAPKs; Microtubule; PP2A; Tributyltin

Indexed keywords

CASPASE-3; MAPKS; MICROTUBULES; PP2A; TRIBUTYLTIN;

CELL DEATH; SIGNAL TRANSDUCTION;

INSECTICIDES;

ACTIVATING TRANSCRIPTION FACTOR 2; CASPASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOPROTEIN PHOSPHATASE 2A; PROCASPASE 3; STRESS ACTIVATED PROTEIN KINASE; TRIBUTYLTIN;

APOPTOSIS; ENZYME ACTIVITY; INHIBITION; INHIBITOR; MAMMAL; TRIBUTYLTIN;

AMNION CELL; APOPTOSIS; ARTICLE; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEPOLYMERIZATION; DISSOCIATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MICROTUBULE; MICROTUBULE ASSEMBLY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ACTIVATING TRANSCRIPTION FACTOR 2; AMNION; APOPTOSIS; CASPASE 3; CELL LINE; ENVIRONMENTAL POLLUTANTS; ENZYME ACTIVATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICROTUBULES; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; SIGNAL TRANSDUCTION; TRIALKYLTIN COMPOUNDS;

MAMMALIA;

EID: 84879601126     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20730     Document Type: Article

References (47)

1. Aluoch AO, Odman-Ghazi SO, Whalen MM. 2007. Pattern of MAP kinases p44/42 and JNK activation by non-lethal doses of tributyltin in human natural killer cells. Arch Toxicol 81: 271-277.
2. Antizar-Ladislao B. 2008. Environmental levels, toxicity and human exposure to tributyltin (TBT)-contaminated marine environment. A review. Environ Int 34: 292-308.
3. Asakawa H, Tsunoda M, Kaido T, Hosokawa M, Sugaya C, Inoue Y, Kudo Y, Satoh T, Katagiri H, Akita H, Saji M, Wakasa M, Negishi T, Tashiro T, Aizawa Y. 2010. Enhanced inhibitory effects of TBT chloride on the development of F1 rats. Arch Environ Contam Toxicol 58: 1065-1073.
4. Boudreau RT, Conrad DM, Hoskin DW. 2007. Apoptosis induced by protein phosphatase 2A (PP2A) inhibition in T leukemia cells is negatively regulated by PP2A-associated p38 mitogen-activated protein kinase. Cell Signal 19: 139-151.
5. Cao D, Jiang G, Zhou Q, Yang R. 2009. Organotin pollution in China: An overview of the current state and potential health risk. J Environ Manage 90: 16-24.
6. Chen J, Gu HY, Lu N, Yang Y, Liu W, Qi Q, Rong JJ, Wang XT, You QD, Guo QL. 2008a. Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells. Life Sci 83: 103-109.
7. Chen KC, Liu WH, Kao PH, Chang LS. 2010a. Calcium-stimulated mitogen-activated protein kinase activation elicits Bcl-xL downregulation and Bak upregulation in notexin-treated human neuroblastoma SK-N-SH cells. J Cell Physiol 222: 177-186.
8. Chen L, Liu L, Huang S. 2008b. Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5. Free Radic Biol Med 45: 1035-1044.
9. Chen L, Liu L, Yin J, Luo Y, Huang S. 2009. Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway. Int J Biochem Cell Biol 41: 1284-1295.
10. Chen TH, Pan SL, Guh JH, Liao CH, Huang DY, Chen CC, Teng CM. 2008c. Moscatilin induces apoptosis in human colorectal cancer cells: A crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage. Clin Cancer Res 14: 4250-4258.
11. Chen YJ, Liu WH, Kao PH, Wang JJ, Chang LS. 2010b. Involvement of p38 MAPK- and JNK-modulated expression of Bcl-2 and Bax in Naja nigricollis CMS-9-induced apoptosis of human leukemia K562 cells. Toxicon 55: 1306-1316.
12. Datta S, Mazumder S, Ghosh D, Dey S, Bhattacharya S. 2009. Low concentration of arsenic could induce caspase-3 mediated head kidney macrophage apoptosis with JNK-p38 activation in Clarias batrachus. Toxicol Appl Pharmacol 241: 329-338.
13. Deng YT, Huang HC, Lin JK. 2010. Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signaling. Mol Carcinog 49: 141-151.
14. Garcia A, Cayla X, Guergnon J, Dessauge F, Hospital V, Rebollo MP, Fleischer A, Rebollo A. 2003. Serine/threonine protein phosphatases PP1 and PP2A are key players in apoptosis. Biochimie 85: 721-726.
15. Jiang H, Liang C, Liu X, Jiang Q, He Z, Wu J, Pan X, Ren Y, Fan M, Li M, Wu Z. 2010. Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways. Atherosclerosis 210: 71-77.
16. Jurkiewicz M, Averill-Bates DA, Marion M, Denizeau F. 2004. Involvement of mitochondrial and death receptor pathways in tributyltin-induced apoptosis in rat hepatocytes. Biochim Biophys Acta 1693: 15-27.
17. Junttila MR, Li SP, Westermarck J. 2008. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J 22: 954-965.
18. Kang YH, Lee SJ. 2008. The Role of p38 MAPK and JNK in Arsenic trioxide-induced mitochondrial cell death in human cervical cancer cells. J cell Physiol 217: 23-33.
19. Kannan K, Takahashi S, Fujiwara N, Mizukawa H, Tanabe S. 2010. Organotin compounds, including Butyltins and Octyltins, in house dust from Albany. New York, USA. Arch Environ Contam Toxicol 58: 901-907.
20. Kim SK, Kim JH, Han JH, Yoon YD. 2008. Inhibitory effect of tributyltin on expression of steroidogenic enzymes in mouse testis. Int J Toxicol 27: 175-182.
21. Kimbrough RD. 1976. Toxicity and health effects of selected organotins compounds: A review. Environ Health Perspect 14: 51-56.
22. Komatsu M, Furukawa T, Ikeda R, Takumi S, Nong Q, Aoyama K, Akiyama S, Keppler D, Takeuchi T. 2007. Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3. Toxicol Sci 97: 407-416.
23. Lavastre V, Girard D. 2002. Tributyltin induces human neutrophil apoptosis and selective degradation of cytoskeletal proteins by caspases. J Toxicol Environ Health A 65: 1013-1024.
24. Lee T, Kim SJ, Sumpio BE. 2003. Role of PP2A in the regulation of p 38 MAPK activation in bovine aortic endothelial cells exposed to cyclic strain. J Cell Physiol 194: 349-355.
25. Li W, Xie L, Chen Z, Zhu Y, Sun Y, Miao Y, Xu Z, Han X. 2010. Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2/M cell-cycle arrest and apoptosis. Cancer Sci 101: 1226-1233.
26. Liu B, Han M, Sun RH, Wang JJ, Zhang YP, Zhang DQ, Wen JK. 2010. ABL-N-induced apoptosis in human breast cancer cells is partially mediated by c-Jun NH2-terminal kinase activation. Breast Cancer Res 12: R9.
27. Nakatsu Y, Kotake Y, Ohta S. 2007. Concentration dependence of the mechanisms of tributyltin-induced Apoptosis. Toxicol Sci 97: 438-447.
28. Nielsen JB, Strand J. 2002. Butyltin compounds in human liver. Environ Res 88: 129-133.
29. Raffray M, McCarthy D, Snowden RT, Cohen GM. 1993. Apoptosis as a mechanism of tributyltin cytotoxicity to thymocytes: Relationship of apoptotic markers to biochemical and cellular effects. Toxicol Appl Pharmacol 119: 122-130.
30. Rodríguez-Ortega MJ, Grøsvik BE, Rodríguez-Ariza A, Goksøyr A, López-Barea J. 2003. Changes in protein expression profiles in bivalve molluscs (Chamaelea gallina) exposed to four model environmental pollutants. Proteomics 3: 1535-1543.
31. Roper WL. 1992. Toxicological profile for tin. U.S. Department of Health and Human Services. Agency for Toxic Substances and Disease Registry: USA.
32. Shanley TP, Vasi N, Denenberg A, Wong HR. 2001. The serine/threonine phosphatase. PP2A: Endogenous regulator of inflammatory cell signaling. J Immunol 166: 966-972.
33. Stridh H, Cotgreave I, Müller M, Orrenius S, Gigliotti D. 2001. Organotin-induced caspase activation and apoptosis in human peripheral blood lymphocytes. Chem Res Toxicol 14: 791-798.
34. Su JC, Lin KL, Chien CM, Lu CM, Chen YL, Chang LS, Lin SR. 2009. Novel indoloquinoline derivative. IQDMA, induces G(2)/M phase arrest and apoptosis in A549 cells through JNK/p38 MAPK signaling activation. Life Sci 85: 505-516.
35. Sundaresan P, Farndale RW. 2002. p38 mitogen-activated protein kinase dephosphorylation is regulated by protein phosphatase 2A in human platelets activated by collagen. FEBS Lett 528: 139-144.
36. Tada-Oikawa S, Kato T, Kuribayashi K, Nishino K, Murata M, Kawanishi S. 2008. Critical role of hydrogen peroxide in the differential susceptibility of Th1 and Th2 cells to tributyltin-induced apoptosis. Biochem Pharmacol 75: 552-561.
37. Tar K, Birukova AA, Csortos C, Bakó E, Garcia JG, Verin AD. 2004. Phosphatase 2A is involved in endothelial cell microtubule remodeling and barrier regulation. J Cell Biochem 92: 534-546.
38. Tar K, Csortos C, Czikora I, Olah G, Ma SF, Wadgaonkar R, Gergely P, Garcia JG, Verin AD. 2006. Role of protein phosphatase 2A in the regulation of endothelial cell cytoskeleton structure. J Cell Biochem 98: 931-953.
39. Van Hoof C, Goris J. 2003. Phosphatases in apoptosis: To be or not to be. PP2A is in the heart of the question. Biochim Biophys Acta 1640: 97-104.
40. Wong LL, Zhang D, Chang CF, Koay ES. 2010. Silencing of the PP2A catalytic subunit causes HER-2/neu positive breast cancer cells to undergo apoptosis. Exp Cell Res 316: 3387-3396.
41. Xiao D, Pinto JT, Soh JW, Deguchi A, Gundersen GG, Palazzo AF, Yoon JT, Shirin H, Weinstein IB. 2003. Induction of apoptosis by the garlic-derived compound s-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH (2)-terminal kinase 1 activation. Cancer Res 63: 6825-6837.
42. Yang Y, Zhu X, Chen Y, Wang X, Chen R. 2007. p 38 and JNK MAPK, but not ERK1/2 MAPK, play important role in colchicine-induced cortical neurons apoptosis. Eur J Pharmacol 576: 26-33.
43. Yamada S, Fuji Y, Mikami E, Kawamura N, Hayakawa J. 1993. Small-scale survey of organotin compounds in household commodities. J AOAC Int 76: 436-441.
44. Yoon S, Choi J, Yoon J, Huh JW, Kim D. 2006. Okadaic acid induces JNK activation, bim overexpression and mitochondrial dysfunction in cultured rat cortical neurons. Neurosci Lett 394: 190-195.
45. Yoon SY, Choi JE, Choi JM, Kim DH. 2008. Dynein cleavage and microtubule accumulation in okadaic acid-treated neurons. Neurosci Lett 437: 111-115.
46. Zhang Y, Zhou L, Bao YL, Wu Y, Yu CL, Huang YX, Sun Y, Zheng LH, Li YX. 2010. Butyrate induces cell apoptosis through activation of JNK MAP kinase pathway in human colon cancer RKO cells. Chem Biol Interact 185: 174-181.
47. Zhu X, Xing M, Lou J, Wang X, Fu W, Xu L. 2007. Apoptotic related biochemical changes in human amnion cells induced by tributyltin. Toxicology 230: 45-52.