Inhibitory effect of tributyltin on expression of steroidogenic enzymes in mouse testis

International Journal of Toxicology

Volumn 27, Issue 2, 2008, Pages 175-182

  Kim, Suel Kee ^a   Kim, Jong Hoon ^a   Han, Jung Ho ^b   Yoon, Yong Dal ^c  

^a Korea University   (South Korea)

^b Seoul National University   (South Korea)

^c Hanyang University   (South Korea)

Author keywords

Apoptosis; Steroidogenesis; Testis; Testosterone; Tributyltin

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; CYTOCHROME P450; MESSENGER RNA; STEROID 17ALPHA MONOOXYGENASE; STEROID HORMONE; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE; TRIBUTYLTIN;

ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; GENE EXPRESSION; GERM CELL; LEYDIG CELL; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REPRODUCTIVE TOXICITY; SEMINIFEROUS TUBULE; SIGNAL TRANSDUCTION; STEROIDOGENESIS; TESTIS; TESTIS DEVELOPMENT; TESTOSTERONE BLOOD LEVEL;

17-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; BODY WEIGHT; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; ESTRADIOL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED ICR; ORGAN SIZE; STEROID 17-ALPHA-HYDROXYLASE; STEROIDS; TESTIS; TESTOSTERONE; TRIALKYLTIN COMPOUNDS;

ANIMALIA; MUS;

EID: 42049106290     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1080/10915810801977906     Document Type: Article

References (31)

1. Doering, D. D., S. Steckelbroek, T. Doering, and D. Klingmuller. 2002. Effects of butyltins on human 5alpha-reductase type 1 and type 2 activity. Steroids 67:859-867.
2. Harazono, A., and E. Ema. 2000. Suppression of decidual cell response induced by tributyltin chloride in pseudopregnant rats: a cause of early embryonic loss. Arch. Toxicol. 74:632-637.
3. Harazono, A., M. Ema, and Y. Ogawa. 1996. Preimplantation embryonic loss induced by tributyltin chloride in rats. Toxicol. Lett. 89:185-190.
4. Horiguchi, T. 2006. Masculinization of female gastropod mollusks induced by organotin compounds, focusing on mechanism of actions of tributyltin and triphenyltin for development of imposex. Environ. Sci. 13:77-87.
5. Inoue, S., S. Abe, Y. Oshima, N. Kai, and T. Honjo. 2006. Tributyltin contamination of bivalves in coastal areas around northern Kyushu, Japan. Environ. Toxicol. 21:244-249.
6. Jurkiewicz, M., D. A. Averill-Bates, M. Marion, and F. Denizeau. 2004. Involvement of mitochondrial and death receptor pathways in tributyltin-induced apoptosis in rat hepatocytes. Biochem. Biophys. Acta 1693:15-27.
7. Kim, S. K., J. H. Kim, H. J. Lee, and Y. D. Yoon. 2007. Octylphenol reduces the expression of steroidogenic enzymes and testosterone production in mouse testis. Environ. Toxicol. 22:449-458.
8. Kim, S. K., H. J. Lee, H. Yang, H. S. Kim, and Y. D. Yoon. 2004. Prepubertal exposure to 4-tert-octylphenol induces apoptosis of testicular germ cells in adult rat. Arch. Androl. 50:427-441.
9. Lee, C. J., B. R. Do, J. K. Kim, and Y. D. Yoon. 2000. Pentobarbital and ketamine suppress serum concentrations of sex hormones in the female rat. J. Anesth. 14:187-190.
10. Lee, J., J. H. Richburg, S. C. Younkin, and K. Boekelheide. 1997. The Fas system is a key regulator of germ cell apoptosis in the testis. Endocrinology 138:2081-2088.
11. Lo, S., A. Allera, P. Albers, J. Heimbrecht, E. Jantzen, D. Klingmuller, and S. Steckelbroeck. 2003. Dithioerythritol (DTE) prevents inhibitory effects of triphenyltin (TPT) on the key enzymes of the human sex steroid hormone metabolism. J. Steroid Biochem. Mol. Biol. 84:569-576.
12. McVey, M. J., and G. M. Cooke. 2003. Inhibition of rat testis microsomal 3beta-hydroxysteroid dehydrogenase activity by tributyltin. J. Steroid Biochem. Mol. Biol. 86:99-105.
13. Morcillo, Y., and C. Porte. 1999. Evidence of endocrine disruption in the imposex-affected gastropod Bolinus brandaris. Environ. Res. 81:349-354.
14. Nakajima, Y., G. Sato, S. Ohno, and S. Nakajin. 2005. Tributyltin chloride suppresses the P450c17 transcription involved in testosterone production induced by gonadotropin stimulation in culture pig Leydig cells. Environ. Toxicol. Pharmacol. 20:11-17.
15. O'Shaughnessy, P. J., L. Willerton, and P. J. Baker. 2002. Changes in Leydig cell gene expression during development in the mouse. Biol. Reprod. 66:966-975.
16. Ohno, S., Y. Nakajima, and S. Nakajin. 2005. Triphenyltin and tributyltin inhibit pig testicular 17β-hydroxysteroid dehydrogenase activity and suppress testicular testosterone biosynthesis. Steroids 70:645-651.
17. Omura, M., R. Ogata, K. Kudo, Y. Shimasaki, S. Aou, Y. Oshima, A. Tanaka, M. Hirata, Y. Makita, and N. Inoue. 2001. Two-generation reproductive toxicity study of tributyltin chloride in male rats. Toxicol. Sci. 64:224-232.
18. Park, J. D., S. S. Habeebu, and C. D. Klaassen. 2002. Testicular toxicity of di-(2-ethylhexyl)phthalate in young Sprague-Dawley rats. Toxicology 171:105-115.
19. Payne, A. H., and G. L. Youngblood. 1995. Regulation of expression of steroidogenic enzymes in Leydig cells. Biol. Reprod. 52:217-225.
20. Peter, M., and J. M. Dubuis. 2000. Transcription factors as regulators of steroidogenic P450 enzymes. Eur. J. Clin. Invest. 30(Suppl 3):14-20.
21. Pons, S., and I. Torres-Aleman. 1993. Estradiol modulates insulin-like growth factor I receptors and binding proteins in neurons from the hypothalamus. J. Neuroendocrinol. 5:267-271.
22. Shawky, S., and H. Emons. 1998. Distribution pattern of organotin compounds at different trophic levels of aquatic ecosystems. Chemosphere 36:523-535.
23. Sinha Hikim, A. P., Y. Lue, M. Diaz-Romero, P. H. Yen, C. Wang, and R. S. Swerdloff. 2003. Deciphering the pathways of germ cell apoptosis in the testis. J. Steroid Biochem. Mol. Biol. 85:175-182.
24. Sudaryanto, A., S. Takahashi, I. Monirith, A. Ismail, M. Muchtar, J. Zheng, B. J. Richardson, A. Subramanian, M. Prudente, N. D. Hue, and S. Tanabe. 2002. Asia-Pacific mussel watch: monitoring of butyltin contamination in coastal waters of Asian developing countries. Environ. Toxicol. Chem. 21:2119-2130.
25. Takahashi, S., H. Mukai, S. Tanabe, K. Sakayama, T. Miyazaki, and H. Masuno. 1999. Butyltin residues in livers of humans and wild terrestrial mammals and in plastic products. Environ. Pollut. 106:213-218.
26. Tremblay, J. J., and R. S. Viger. 2003. Novel roles for GATA4 transcription factors in the regulation of steroidogenesis. J. Steroid Biochem. Mol. Biol. 85:291-298.
27. Tsuda, T., T. Inoue, M. Kojima, and S Aoki. 1995. Daily intakes of tributyltin and triphenyltin compounds from meals. J. AOAC Int. 78:941-943.
28. Umebayashi, C., Y. Oyama, L. Chikahisa-Muramastu, H. Nakao, Y. Nishizaki, M. Nakata, F. Soeda, and K. Takahama. 2004. Tri-n-butyltin-induced cytotoxicity on rat thymocytes in presence and absence of serum. Toxicol. In Vitro 18:55-61.
29. Yu, W. J., B. J. Lee, S. Y. Nam, Y. C. Kim, Y. S. Lee, and Y. W. Yun. 2003a. Spermatogenetic disorders in adult rats exposed to tributyltin chloride during puberty. J. Vet. Med. Sci. 65:1331-1335.
30. Yu, W. J., S. Y. Nam, Y. C. Kim, B. J. Lee, and Y. W. Yun. 2003b. Effects of tributyltin chloride on the reproductive system in pubertal male rats. J. Vet. Sci. 4:29-34.
31. Yu, X., H. Kubota, R. Wang, J. Saegusa, Y. Ogawa, G. Ichihara, Y. Takeuchi, and N. Hisanaga. 2001. Involvement of Bcl-2 family genes and Fas signaling system in primary and secondary male germ cell apoptosis induced by 2-bromopropane in rat. Toxicol. Appl. Pharmacol. 174:35-48.