Decreased secretion and unfolded protein response up-regulation are correlated with intracellular retention for single-chain antibody variants produced in yeast

Biotechnology and Bioengineering

Volumn 104, Issue 1, 2009, Pages 20-29

  Xu, Ping ^a   Robinson, Anne Skaja ^a  

^a University of Delaware   (United States)

Author keywords

Chaperone; Kar2; Protein folding; Protein secretion; Saccharomyces cerevisiae; Single chain antibody

Indexed keywords

CHAPERONE; KAR2; PROTEIN SECRETION; SACCHAROMYCES CEREVISIAE; SINGLE-CHAIN ANTIBODY;

ANTIBODIES; CELL MEMBRANES; YEAST;

PROTEIN FOLDING;

CHAPERONE;

ALGORITHM; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; IMMUNOPRECIPITATION; IN VIVO STUDY; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN SECRETION; PROTEIN SYNTHESIS; SCORING SYSTEM; SCREENING; SIGNAL TRANSDUCTION; UPREGULATION; YEAST;

ANTIBODIES; FUNGAL PROTEINS; HSP70 HEAT-SHOCK PROTEINS; IMMUNOPRECIPITATION; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECOMBINANT PROTEINS; SACCHAROMYCES;

SACCHAROMYCES CEREVISIAE;

EID: 69249138319     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22376     Document Type: Article

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