Alcohol-induced IL-1β in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation

Journal of Leukocyte Biology

Volumn 94, Issue 1, 2013, Pages 171-182

  Lippai, Dora ^a   Bala, Shashi ^a   Petrasek, Jan ^a   Csak, Timea ^a   Levin, Ivan ^a   Kurt Jones, Evelyn A ^a   Szabo, Gyongyi ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Cerebellum; CNS; HMGB1; MCP 1; TNF

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; ALCOHOL; APOPTOSIS ASSOCIATED SPECK LIKE PROTEIN CONTAINING A CASPASE RECRUITMENT DOMAIN; CRYOPYRIN; ENDOTOXIN; HIGH MOBILITY GROUP B1 PROTEIN; INFLAMMASOME; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MONOCYTE CHEMOTACTIC PROTEIN 1; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LEUCINE RICH REPEAT AND PYRIN DOMAIN CONTAINING PROTEIN 1; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACETYLATION; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CEREBELLUM; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; EXPERIMENTAL MODEL; FEMALE; KNOCKOUT MOUSE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

CEREBELLUM; CNS; HMGB1; MCP-1; TNF-Α;

ACETYLATION; ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; BLOTTING, WESTERN; BRAIN; CARRIER PROTEINS; CYTOKINES; CYTOSKELETAL PROTEINS; ETHANOL; FEMALE; HMGB1 PROTEIN; IMMUNOPRECIPITATION; INFLAMMASOMES; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1BETA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, INTERLEUKIN-1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

MUS;

EID: 84879582334     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.1212659     Document Type: Article

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