Rapid scanning structure-activity relationships in combinatorial data sets: Identification of activity switches

Journal of Chemical Information and Modeling

Volumn 53, Issue 6, 2013, Pages 1475-1485

  Medina Franco, José L ^a   Edwards, Bruce S ^b   Pinilla, Clemencia ^a   Appel, Jon R ^a   Giulianotti, Marc A ^a   Santos, Radleigh G ^a   Yongye, Austin B ^a   Sklar, Larry A ^b   Houghten, Richard A ^a,b  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY;

DECONVOLUTION METHOD; DIKETOPIPERAZINES; DOUBLE SUBSTITUTION; MOLECULAR TEMPLATE; PAIR-WISE COMPARISON; QUANTITATIVE IDENTIFICATION; RAPID IDENTIFICATION; STRUCTURE-ACTIVITY RELATIONSHIPS;

SCANNING;

FORMYLPEPTIDE RECEPTOR; PIPERAZINEDIONE; PYRROLIDINE DERIVATIVE;

CHEMISTRY; DRUG DATABASE; DRUG DEVELOPMENT; HUMAN; METABOLISM; PROCEDURES; STRUCTURE ACTIVITY RELATION; ARTICLE; METHODOLOGY;

DATABASES, PHARMACEUTICAL; DIKETOPIPERAZINES; DRUG DISCOVERY; HUMANS; PYRROLIDINES; RECEPTORS, FORMYL PEPTIDE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84879562497     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci400192y     Document Type: Article

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