Activity landscape modeling of PPAR ligands with dual-activity difference maps

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 11, 2012, Pages 3523-3532

  Méndez Lucio, Oscar ^a   Pérez Villanueva, Jaime ^b   Castillo, Rafael ^a   Medina Franco, José L ^c  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b DEPARTAMENTO DE SISTEMAS BIOLÓGICOS   (Mexico)

^c TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

Activity cliffs; Diabetes mellitus; Dual activity difference maps; PPAR agonist; Structure activity relationships

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ACTIVITY LANDSCAPE MODELING; ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; HYDROGEN BOND; MOLECULAR MODEL; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION;

DRUG EVALUATION, PRECLINICAL; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PPAR ALPHA; PPAR DELTA; PPAR GAMMA; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMULUS;

EID: 84861193545     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.04.005     Document Type: Article

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