Paradoxical effect of increased diastolic Ca2+ release and decreased sinoatrial node activity in a mouse model of catecholaminergic polymorphic ventricular tachycardia

Circulation

Volumn 126, Issue 4, 2012, Pages 392-401

  Neco, Patricia ^a,b   Torrente, Angelo G ^c   Mesirca, Pietro ^c   Zorio, Esther ^d   Liu, Nian ^e   Priori, Silvia G ^e,f   Napolitano, Carlo ^e,f   Richard, Sylvain ^b   Benitah, Jean Pierre ^a,b   Mangoni, Matteo E ^c   Gómez, Ana María ^a,b  

^a Universite Paris Sud   (France)

^b INSERM   (France)

^c INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^d HOSPITAL UNIVERSITARIO LA FE   (Spain)

^e UNIVERSITY OF PAVIA   (Italy)

^f NEW YORK UNIVERSITY   (United States)

Author keywords

arrhythmias; calcium; cardiac; polymorphic catecholaminergic ventricular tachycardia; sinoatrial node

Indexed keywords

BETA ADRENERGIC RECEPTOR; ISOPRENALINE;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA; CHRONOTROPISM; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DIASTOLE; FEMALE; HUMAN; MALE; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; SINUS NODE; SINUS NODE DYSFUNCTION; WHOLE CELL;

ACTION POTENTIALS; ADRENERGIC BETA-AGONISTS; ADULT; AGED; ANIMALS; CALCIUM; CALCIUM SIGNALING; DISEASE MODELS, ANIMAL; EXERCISE; FEMALE; HUMANS; ISOPROTERENOL; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MIDDLE AGED; MUTATION; PATCH-CLAMP TECHNIQUES; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; SINOATRIAL NODE; TACHYCARDIA, VENTRICULAR;

EID: 84864284410     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.075382     Document Type: Article

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